LncRNA Information
ID EL1400 Name Tug1 Aliases AI316828
Species Mus musculus Chromosome 11 Start site 3639785
End site 3649673 Chain minus Exon NO. 4
Assembly Ensembl Release 89 Class antisense NCBI accession NR_002321, NR_110490, NR_002322
Ensembl ENSMUSG00000056579 Sequence

Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
Northern blots and in situ hybridization, knockdown, Immunofluorescent staining and microarray analyses retina N/A expression Tug1 is necessary for the proper formation of photoreceptors in the developing rodent retina. 15797018
qRT-PCR, knockdown, MTT, TUNEL and Annexin V-FITC assays and western blot, GSIS, ELISA and immunochemistry mouse pancreatic β cell up-regulated expression Knockdown of lncRNA TUG1 expression resulted in an increased apoptosis ratio and decreased insulin secretion in β cells both in vitro and in vivo 25871529
RNA-seq, overexpression mouse hepatocytes and liver sinusoidal endothelial cells LSECs down-regulated expression Overexpression of TUG1 attenuated cold-induced apoptosis in mouse hepatocytes and liver sinusoidal endothelial cells LSECs, in part by blocking mitochondrial apoptosis and endoplasmic reticulum (ER) stress pathways. TUG1 attenuated apoptosis, inflammation, and oxidative stress in vivo in livers subjected to cold storage. Overexpression of TUG1 also improved hepatocyte function and prolonged hepatic graft survival rates in mice. These results suggest that the lncRNA TUG1 exerts a protective effect against cold-induced liver damage by inhibiting apoptosis in mice, and suggests a potential role for TUG1 as a target for the prevention of cold-induced liver damage in liver transplantation. 26785829

Interaction target Level of interaction Type of interaction Description PMID Source
PRC2 RNA-Protein binding Numerous lincRNAs are physically associated with PRC2. 19571010 LncRNADisease