LncRNA Information
ID EL1366 Name TRPM2-AS Aliases TRPM2-AS1
Species Homo sapiens Chromosome 21 Start site 44414588
End site 44425272 Chain minus Exon NO. 3
Assembly Ensembl Release 89 Class antisense NCBI accession NR_109964
Ensembl ENSG00000230061 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
prostate cancer microarray, qPCR etc. cell line (PC3) differential expression expression This essential role, coupled to the TRPM2-AS low-expression levels in healthy tissues, makes this ncRNA a suitable therapeutic target for further clinical studies. To get insights into the survival mechanism controlled by this molecule, we ablated its expression in prostate cancer cells and performed a genome-wide analysis of the transcripts differentially regulated in dying cells. 26484139 Lnc2Cancer
prostate cancer microarray, qPCR, knockdown etc. prostate cancer tissue, cell lines (PNT1A, PC3 etc.) up-regulated N/A TRPM2-AS is overexpressed in prostate cancer (PCa). The high expression of TRPM2-AS and its related gene signature were found to be linked to poor clinical outcome, with the related gene signature working also independently of the patient's Gleason score. Mechanistically, TRPM2-AS knockdown led to PCa cell apoptosis, with a transcriptional profile that indicated an unbearable increase in cellular stress in the dying cells, which was coupled to cell cycle arrest, an increase in intracellular hydrogen peroxide and activation of the sense TRPM2 gene. 24931166 Lnc2Cancer