LncRNA Information | ||||||
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ID | EL1337 | Name | TIP ncRNA | Aliases | N/A | |
Species | Mus musculus | Chromosome | N/A | Start site | N/A | |
End site | N/A | Chain | N/A | Exon NO. | N/A | |
Assembly | N/A | Class | N/A | NCBI accession | N/A | |
Ensembl | N/A | Sequence | N/A |
Function (not disease relevant) | |||||||||
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Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
Profiling | murine in vitro neural differentiation system | N/A | N/A | TIP transcription may ensure coordinated regulation of gene networks via dynamic switching and recruitment of PcG proteins both in cis and in trans during lineage commitment. | 22336714 | ||||
Interaction | |||||||||
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Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
Polycomb (PcG) proteins | RNA-Protein | regulation | The relationship between TIP transcription and PcG recruitment switches dynamically during differentiation between different states, in which transcription and PcG recruitment exclude each other, or in which both are present. Reporter assays show that transcribed TIP sites can repress a flanking gene. Knockdown experiments demonstrate that TIP ncRNAs are themselves required for repression of target genes both in cis and in trans. | 22336714 | |||||