LncRNA Information
ID EL1337 Name TIP ncRNA Aliases N/A
Species Mus musculus Chromosome N/A Start site N/A
End site N/A Chain N/A Exon NO. N/A
Assembly N/A Class N/A NCBI accession N/A
Ensembl N/A Sequence N/A

Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
Profiling murine in vitro neural differentiation system N/A N/A TIP transcription may ensure coordinated regulation of gene networks via dynamic switching and recruitment of PcG proteins both in cis and in trans during lineage commitment. 22336714

Interaction target Level of interaction Type of interaction Description PMID Source
Polycomb (PcG) proteins RNA-Protein regulation The relationship between TIP transcription and PcG recruitment switches dynamically during differentiation between different states, in which transcription and PcG recruitment exclude each other, or in which both are present. Reporter assays show that transcribed TIP sites can repress a flanking gene. Knockdown experiments demonstrate that TIP ncRNAs are themselves required for repression of target genes both in cis and in trans. 22336714