LncRNA Information
ID EL1336 Name TINCR Aliases LINC00036; NCRNA00036; PLAC2; onco-lncRNA-16
Species Homo sapiens Chromosome 19 Start site 5558167
End site 5568034 Chain minus Exon NO. 3
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_027064
Ensembl ENSG00000223573 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
skin desease Genome-scale RNA interactome analysis, high-throughput screen N/A N/A N/A controls human epidermal differentiation by a post-transcriptional mechanism 23201690
colorectal cancer N/A CRC tissues and metastatic CRC cell lines up-regulated N/A TINCR was reversely correlated with CRC progression 27009809
squamous cell carcinoma N/A N/A N/A expression Interestingly, the lncRNA TINCR, which is highly induced during keratinocyte differentiation, is repressed in squamous cell carcinoma specimens compared to normal adjacent epidermis. 24115003 LncRNADisease
gastric cancer RNA-seq, qPCR, Western blot, knockdown etc. gastric cancer tissue, cell lines (MGC803, BGC823, MKN45, SGC7901 etc.) up-regulated N/A TINCR is strongly upregulated in human gastric carcinoma (GC), where it was found to contribute to oncogenesis and cancer progression. TINCR overexpression is induced by nuclear transcription factor SP1. TINCR contributes to the oncogenic potential of GC and may constitute a potential therapeutic target in this disease. 25728677 LncRNADisease Lnc2Cancer

Interaction target Level of interaction Type of interaction Description PMID Source
staufen1 (STAU1) protein RNA-Protein binding A high-throughput screen to analyse TINCR binding capacity to approximately 9,400 human recombinant proteins revealed direct binding of TINCR RNA to the staufen1 (STAU1) protein. 23201690