LncRNA Information
ID EL1323 Name TER1 Aliases N/A
Species Arabidopsis thaliana Chromosome N/A Start site N/A
End site N/A Chain N/A Exon NO. N/A
Assembly N/A Class N/A NCBI accession N/A
Ensembl N/A Sequence N/A

Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
RT-PCR DNA damage down-regulated N/A As the essential RNA subunit of telomerase, TER1 is required for telomere maintenance, while TER2 is assembled in distinct RNP complex (es)to modulate telomerase activity in response to DNA damage. (Wang et al., 2014) TER1 and TER2 copurify with telomerase activity and serve as templates for telomerase in vitro, depletion of TER1, but not TER2, leads to decreased telomerase activity and progressive telomere shortening in vivo. Moreover, mutation of the templating domain in TER1 results in the incorporation of mutant telomere repeats on chromosome ends. Thus, TER1 provides the major template for telomerase in vivo. Both TER1 and TER2 function as templates for TERT in vitro, but only TER1 plays a significant role in telomere maintenance in vivo. Moreover, we show that TER1, but not TER2, specifically binds POT1a in vitro and the two components assemble into an enzymatically active RNP in vivo. These findings underscore the evolution of telomerase and telomere proteins in Arabidopsis and argue that the process is driven by gene duplication. (Cifuentes-Rojas et al., 2011) 24398630, 21164032 PLNlncRbase