LncRNA Information
ID EL1236 Name SOX2-OT Aliases NCRNA00043; SOX2OT
Species Homo sapiens Chromosome 3 Start site 180989770
End site 181836880 Chain plus Exon NO. 10
Assembly Ensembl Release 89 Class sense overlapping NCBI accession NR_075091, NR_075092, NR_075093, NR_004053, NR_075089, NR_075090
Ensembl ENSG00000242808 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
Alzheimer's disease N/A N/A N/A expression We selected three differential signature genes specific for the early stage (Nudt19, Arl16, Aph1b), five common to both groups (Slc15a2, Agpat5, Sox2ot, 2210015, D19Rik, Wdfy1), and seven specific for late stage (D14Ertd449, Tia1, Txnl4, 1810014B01Rik). 21961160 LncRNADisease
Neurodevelopmental syndromes associated with the SOX2 locus N/A N/A N/A regulation Genomic context links lncRNAs to disease genes/loci and related pathways 23791884 LncRNADisease
esophageal squamous cell carcinoma N/A N/A N/A expression The results revealed a significant co-upregulation of SOX2OT along with SOX2 and OCT4 in tumor samples, compared to the non-tumor tissues obtained from the margin of same tumors. Therefore, the SOX2 gene might be a indicator for the early diagnosis of ESCC. 24817925 LncRNADisease
esophageal squamous cell carcinoma qPCR, knockdown etc. ESCC tissue, cell lines (NT2, U-87 MG etc.) up-regulated N/A Our data revealed a high level of SOX2OT expression in tumor samples of ESCC, compared to that of apparently normal marginal tissues obtained from the same patients (P<0.01). All together, our data provide a novel regulatory mechanism governing the key stem cell pluripotency genes, SOX2 and OCT4, mediated by the lncRNA SOX2OT. 24105929 Lnc2Cancer
hepatocelluar carcinoma qPCR, knockdown etc. HCC tissue, cell lines (HepG2, SMMC-7721) up-regulated expression lncRNA Sox2ot expression level was significantly higher in HCC tissues compared with adjacent non-tumor tissues. High expression of lncRNA Sox2ot was associated with histological grade, TNM stage, and vein invasion. 26097588 Lnc2Cancer
breast cancer qPCR, Western blot etc. cell lines (MCF10A) up-regulated N/A The expression of SOX2 and SOX2OT is concordant in breast cancer, differentially expressed in estrogen receptor positive and negative breast cancer samples and that both are up-regulated in suspension culture conditions that favor growth of stem cell phenotypes. Importantly, ectopic expression of SOX2OT led to an almost 20-fold increase in SOX2 expression, together with a reduced proliferation and increased breast cancer cell anchorage-independent growth. 25006803 Lnc2Cancer
lung squamous cell carcinoma qPCR, Western blot, knockdown, RIP etc. cell lines (A549, HCC827, SK-MES-1, NCI-H1299 etc.) up-regulated N/A Sox2ot exprssion in lung cancer is significantly higher and promotes cancer cell proliferation. Sox2ot plays an important role in regulating lung cancer cell proliferation, and may represent a novel prognostic indicator for the disease. 24927902 Lnc2Cancer
non-small cell lung cancer real-time quantitative reverse transcription PCR (qRT-PCR) lung tumor tissues up-regulated N/A SOX2OT knockdown significantly reduced the colony formation ability of cancer cells 26846097

Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
real-time polymerase chain reaction (RT-PCR) NT-2 pluripotent cell line down-regulated N/A the down-regulation of SOX2OT and SOX2 genes by an miRNA 26862518
real-time RT-PCR five human cancer cell lines N/A mutation SOX2OT-7 is almost the most abundant form of SOX2OT transcript variants in the examined cancer cell lines particularly in NT2 teratocarcinoma cell line where its expression falls upon neuronal-like differentiation similar to SOX2 and OCT4A. 26703382
real-time RT-PCR five human cancer cell lines N/A mutation N/A 26703382
TaqMan gene expression assays, QPCR human TK6 (p53 positive) and WTK1 (p53 negative) cells up-regulated expression The lncRNA MALAT1 and SOX2OT were induced in both TK6 and WTK1 cells 23698766

Interaction target Level of interaction Type of interaction Description PMID Source
miR-211 RNA-RNA regulation Overexpression of miR-211 caused a significant down-regulation of both genes (SOX2OT and SOX2 genes). 26862518