| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL1131 | Name | roX2 | Aliases | Dmel_CR32665; CR32665; DmelCR32665; RoX2; roX; rox2 | |
| Species | Drosophila melanogaster | Chromosome | X | Start site | 11579065 | |
| End site | 11580432 | Chain | plus | Exon NO. | 1 | |
| Assembly | Release 6 plus ISO1 MT | Class | N/A | NCBI accession | NR_002104, NR_002105, NR_047796, NR_047795, NR_123871, NR_123872 | |
| Ensembl | N/A | Sequence | ||||
| Function (not disease relevant) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
| N/A | N/A | N/A | mutation | Genetic rescue by roX orthologs and engineered synthetic lncRNAs showed that altering the number of focal, repetitive RNA structures determines roX ortholog function. Genomic occupancy maps of roX RNAs in four species revealed conserved targeting of X chromosome neighborhoods but rapid turnover of individual binding sites. Many new roX-binding sites evolved from DNA encoding a pre-existing RNA splicing signal, effectively linking dosage compensation to transcribed genes. Thus, dynamic change in lncRNAs and their genomic targets underlies conserved and essential lncRNA-genome interactions. | 26773003 | ||||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| MSL complex | RNA-Protein | binding | In Drosophila, dosage compensation is controlled by the male-specific lethal (MSL) complex consisting of at least five proteins and two noncoding RNAs, roX1 and roX2. | 15229655 | LncRNADisease | ||||
| MSL complex | RNA-Protein | binding | Comparison of the high-resolution map from roX2 CHART with published data for the MSL complex achieved by using ChIP revealed that roX2 binds at the same sites in chromatin as the MSL complex. | 22143764 | LncRNADisease | ||||