LncRNA Information
ID EL1131 Name roX2 Aliases Dmel_CR32665; CR32665; DmelCR32665; RoX2; roX; rox2
Species Drosophila melanogaster Chromosome X Start site 11579065
End site 11580432 Chain plus Exon NO. 1
Assembly Release 6 plus ISO1 MT Class N/A NCBI accession NR_002104, NR_002105, NR_047796, NR_047795, NR_123871, NR_123872
Ensembl N/A Sequence

Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
N/A N/A N/A mutation Genetic rescue by roX orthologs and engineered synthetic lncRNAs showed that altering the number of focal, repetitive RNA structures determines roX ortholog function. Genomic occupancy maps of roX RNAs in four species revealed conserved targeting of X chromosome neighborhoods but rapid turnover of individual binding sites. Many new roX-binding sites evolved from DNA encoding a pre-existing RNA splicing signal, effectively linking dosage compensation to transcribed genes. Thus, dynamic change in lncRNAs and their genomic targets underlies conserved and essential lncRNA-genome interactions. 26773003

Interaction target Level of interaction Type of interaction Description PMID Source
MSL complex RNA-Protein binding In Drosophila, dosage compensation is controlled by the male-specific lethal (MSL) complex consisting of at least five proteins and two noncoding RNAs, roX1 and roX2. 15229655 LncRNADisease
MSL complex RNA-Protein binding Comparison of the high-resolution map from roX2 CHART with published data for the MSL complex achieved by using ChIP revealed that roX2 binds at the same sites in chromatin as the MSL complex. 22143764 LncRNADisease