LncRNA Information
ID EL1130 Name roX1 Aliases Dmel_CR32777; BcDNA:GH10432; CR32777; DmelCR32777; EG:EG0002.2; RoX1; chrX:3706836..3706970; roX; rox1
Species Drosophila melanogaster Chromosome X Start site 3857230
End site 3862697 Chain minus Exon NO. 1
Assembly Release 6 plus ISO1 MT Class N/A NCBI accession NR_123784, NR_073631, NR_073632, NR_002097, NR_002098
Ensembl N/A Sequence


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
capture hybridization analysis of RNA targets (CHART) N/A N/A N/A roX2, a well-studied ncRNA involved in dosage compensation in Drosophila. 22143764
N/A N/A N/A mutation Genetic rescue by roX orthologs and engineered synthetic lncRNAs showed that altering the number of focal, repetitive RNA structures determines roX ortholog function. Genomic occupancy maps of roX RNAs in four species revealed conserved targeting of X chromosome neighborhoods but rapid turnover of individual binding sites. Many new roX-binding sites evolved from DNA encoding a pre-existing RNA splicing signal, effectively linking dosage compensation to transcribed genes. Thus, dynamic change in lncRNAs and their genomic targets underlies conserved and essential lncRNA-genome interactions. 26773003
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
MSL complex RNA-Protein binding In Drosophila, dosage compensation is controlled by the male-specific lethal (MSL) complex consisting of at least five proteins and two noncoding RNAs, roX1 and roX2. 15229655 LncRNADisease
MSL1 RNA-Protein binding MSL/MSL2 is recruited by roX. 20573714 LncRNADisease
MSL2 RNA-Protein binding MSL/MSL2 is recruited by roX. 20573714 LncRNADisease
specific genomic sites RNA-DNA binding roX2 binds at specific genomic sites that coincide with the binding sites of proteins from the male-specific lethal complex that affects dosage compensation. 22143764