LncRNA Information
ID EL1120 Name RN7SK Aliases 7SK
Species Homo sapiens Chromosome 6 Start site 52995620
End site 52995950 Chain plus Exon NO. 1
Assembly Ensembl Release 89 Class N/A NCBI accession NR_001445
Ensembl ENSG00000202198 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
cancer N/A N/A N/A Interaction Together with the HEXIM proteins, 7SK RNA associates with and sequesters a fraction of cellular P-TEFb into a catalytically inactive complex. Active and inactive forms of P-TEFb are kept in a functional and dynamic equilibrium tightly linked to the transcriptional requirement of the cell. Importantly, cardiac hypertrophy and development of various types of human malignancies have been associated with increased P-TEFb activity, consequence of a disruption of this regulatory equilibrium. 22377309 LncRNADisease
AIDS N/A N/A N/A Interaction HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. 20471949 LncRNADisease
AIDS N/A N/A N/A Interaction Tat efficiently replaces HEXIM1 on the 7SK snRNA in vivo and therefore, it promotes the disassembly of the 7SK/HEXIM/P-TEFb negative transcriptional regulatory snRNP to augment the nuclear level of active P-TEFb. The human 7SK snRNA carries a TAR RNA-like Tat-binding element that is essential for the normal transcriptional regulatory function of 7SK questions the viability of HIV therapeutic approaches based on small drugs blocking the Tat-binding site of HIV TAR. 20976203 LncRNADisease
AIDS N/A N/A N/A Interaction The 7SK-HMGA1 interaction not only adds an essential facet to the comprehension of transcriptional plasticity at the coupling of initiation and elongation, but also might provide a molecular link between HIV reprogramming of cellular gene expression-associated oncogenesis. 21087998 LncRNADisease
AIDS N/A N/A N/A expression Stable expression of cdNIPP1 increased CDK9 phosphorylation on Thr(186) and the association of CDK9 with 7SK RNA. The stable expression of cdNIPP1 disrupted the interaction of Tat and PP1 and inhibited HIV-1 transcription. Expression of cdNIPP1 as a part of the HIV-1 genome inhibited HIV-1 replication. 21098020 LncRNADisease
AIDS N/A N/A N/A Interaction The HIV-1 Tat protein also releases P-TEFb from the 7SK/HEXIM complex during viral infection to promote viral transcription and replication. 22377309 LncRNADisease
cardiac hypertrophy N/A N/A N/A Interaction Together with the HEXIM proteins, 7SK RNA associates with and sequesters a fraction of cellular P-TEFb into a catalytically inactive complex. Active and inactive forms of P-TEFb are kept in a functional and dynamic equilibrium tightly linked to the transcriptional requirement of the cell. Importantly, cardiac hypertrophy and development of various types of human malignancies have been associated with increased P-TEFb activity, consequence of a disruption of this regulatory equilibrium. 22377309 LncRNADisease
gastric cancer N/A N/A N/A expression Transfection of an siRNA directed against LARP7 (anti-LARP7 siRNA) into non-neoplastic gastric epithelial cells decreased 7sk levels by 72% relative to a control siRNA (P<0.01). 22488152 LncRNADisease
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
Immunoprecipitation,Immunofluorescence microscopy,FISH analysis, HeLa cell N/A interaction N/A 17381310
N/A N/A N/A interaction The 7sk/p-tefb interaction may serve as a principal control point for the induction of cellular and hiv-1 viral gene expression during stress-related responses. 11713532
N/A N/A N/A interaction The transcription-dependent interaction of p-tefb with 7sk may therefore contribute to an important feedback loop modulating the activity of rna pol ii. 11713533
RNA-seq, qRT-PCR three different brain regions (cortex, white matter, and cerebellum) of human postmortem tissue N/A N/A Thus, these 5 lncRNAs may be applicable as references for accurate normalisation of lncRNA profiling in multiple brain regions during long PMI, enabling the generation of highly reproducible datasets in lncRNA studies of the human brain. 25528156
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
P-TEFb RNA-Protein regulation 7sk inhibits general and hiv-1 tat-specific transcriptional activities of p-tefb in vivo and in vitro by inhibiting the kinase activity of cdk9 and preventing recruitment of p-tefb to the hiv-1 promoter. 11713532
P-TEFb RNA-Protein binding The transcription-dependent interaction of p-tefb with 7sk may therefore contribute to an important feedback loop modulating the activity of rna pol ii. 11713533
HEXIM1 RNA-Protein binding Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor. 15201869 LncRNADisease
OCT1 DNA-TF regulation PTF and Oct-1 enhance transcription from the 7SK promoter in an interdependent manner. 1535687 LncRNADisease
PTF DNA-TF regulation PTF and Oct-1 enhance transcription from the 7SK promoter in an interdependent manner. 1535687 LncRNADisease
HEXIM1 RNA-Protein binding 7SK RNA binding to a HEXIM1 multimer promotes the simultaneous recruitment and hence inactivation of multiple P-TEFb units. 15994294 LncRNADisease
APOBEC3C RNA-Protein binding it is unclear how APOBEC3C's activity is controlled to prevent its mutations of genomic DNA. We show that most of APOBEC3C interact with about half of nuclear 7SK, which suppresses APOBEC3C's deaminase activity and sequesters APOBEC3C in the nucleolus where it could be at a safe distance from most genomic sequences. 17381310
BCDIN3 RNA-Protein regulation BCDIN3 is the 7SK snRNA methylphosphate capping enzyme (MePCE) present in an snRNP complex containing both RNA processing and transcription factors, including the elongation factor P-TEFb. 17643375 LncRNADisease
HEXIM1 RNA-Protein binding When associated with 7SK small nuclear RNA, HEXIM1 binds to P-TEFb and inhibits the kinase activity of P-TEFb. 17671421 LncRNADisease
LARP7 RNA-Protein binding PIP7S binds and stabilizes nearly all the nuclear 7SK via 3'-UUU-OH, leading to the sequestration and inactivation of P-TEFb. 18249148 LncRNADisease
LARP7 RNA-Protein binding LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated. 18281698 LncRNADisease
HEXIM1 RNA-Protein binding HEXIM1 suppresses transcription elongation via sequestration of positive transcription elongation factor b (P-TEFb) using 7SK RNA as a scaffold. 18407829 LncRNADisease
PP1a RNA-Protein regulation PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. 18483222 LncRNADisease
PP2B RNA-Protein regulation PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. 18483222 LncRNADisease
LARP7 RNA-Protein binding The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes. 18483487 LncRNADisease
HEXIM1 RNA-Protein binding Dissociation of 7SK and HEXIM1 from P-TEFb promotes P-TEFb kinase activity, and thus enhances Pol II elongation 19239885 LncRNADisease
P-TEFb RNA-Protein regulation Dissociation of 7SK and HEXIM1 from P-TEFb promotes P-TEFb kinase activity, and thus enhances Pol II elongation. 19239885 LncRNADisease
HEXIM1 RNA-Protein binding The Hexim1 binding site is located in the 24-87 region of 7SK RNA and that the protein residues outside the basic domain of Hexim1 are involved in specific RNA interactions. 19244621 LncRNADisease
hLARP7 RNA-Protein binding 7SK snRNP assembly by hLARP7/PIP7S 20138158 LncRNADisease
PIP7S RNA-Protein binding 7SK snRNP assembly by hLARP7/PIP7S 20138158 LncRNADisease
Tat RNA-Protein binding HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. 20471949 LncRNADisease
HEXIM1 RNA-Protein binding HEXIM1 targets a repeated GAUC motif in the riboregulator of transcription 7SK and promotes base pair rearrangements. 20675720 LncRNADisease
HEXIM1 RNA-Protein binding Although HEXIM1 binds tightly to 7SK RNA in vitro, release of P-TEFb from the 7SK snRNP is accompanied by the loss of HEXIM1. 20808803 LncRNADisease
P-TEFb RNA-Protein binding Tat has been shown to bind 7SK directly and recruit P-TEFb to TAR. 20816986 LncRNADisease
HEXIM1 RNA-Protein binding Human T-lymphotropic virus type 1 Tax protein complexes with P-TEFb and competes for Brd4 and 7SK snRNP/HEXIM1 binding. Tax can play a role in regulating the amount of HMW complex present in the cell by decreasing the binding of 7SK snRNP/HEXIM1 to P-TEFb. 20926576 LncRNADisease
Tat RNA-Protein binding Tat efficiently replaces HEXIM1 on the 7SK snRNA in vivo and therefore, it promotes the disassembly of the 7SK/HEXIM/P-TEFb negative transcriptional regulatory snRNP to augment the nuclear level of active P-TEFb. 20976203 LncRNADisease
HMGA1 RNA-Protein binding The 7SK-HMGA1 interaction not only adds an essential facet to the comprehension of transcriptional plasticity at the coupling of initiation and elongation, but also might provide a molecular link between HIV reprogramming of cellular gene expression-associated oncogenesis. 21087998 LncRNADisease
CDK9 RNA-Protein regulation Stable expression of cdNIPP1 increased CDK9 phosphorylation on Thr(186) and the association of CDK9 with 7SK RNA. The stable expression of cdNIPP1 disrupted the interaction of Tat and PP1 and inhibited HIV-1 transcription. Expression of cdNIPP1 as a part of the HIV-1 genome inhibited HIV-1 replication. 21098020 LncRNADisease
HMGA1 RNA-Protein binding 7SK snRNA directly interacts through its loop2 (7SK L2) with the first A/T-hook DNA binding motif of HMGA1. 21282977 LncRNADisease
P-TEFb RNA-Protein binding TCR signaling led to the rapid dissociation of the large inactive P-TEFb:7SK RNP (small nuclear RNA 7SK ribonucleoprotein) complex and the release of active low-molecular-weight P-TEFb complexes. 21763495 LncRNADisease
LARP7 RNA-Protein regulation The Lupus antigen (La)-related protein 7 (LARP7) is a constitutive component, the methylphosphate capping enzyme (MePCE) associates secondarily to phosphorylate the 5' end of 7SK snRNA. 21853533 LncRNADisease
HMGA1 RNA-Protein binding We provide evidence for 7SK RNA complexes containing simultaneously HMGA1 and P-TEFb. 21957495 LncRNADisease
P-TEFb RNA-Protein binding We provide evidence for 7SK RNA complexes containing simultaneously HMGA1 and P-TEFb. 21957495 LncRNADisease
Ars2 RNA-Protein regulation Ars2 contributes to histone mRNA 3'end formation and expression and these functional properties of Ars2 are negatively regulated by interaction with 7SK RNA. 22244333 LncRNADisease
P-TEFb RNA-Protein regulation The kinase activity of P-TEFb is reversibly inhibited by formation of a complex with the 334nt 7SK RNA, from which it is released under conditions of stress. 22303389 LncRNADisease
P-TEFb RNA-Protein binding Together with the HEXIM proteins, 7SK RNA associates with and sequesters a fraction of cellular P-TEFb into a catalytically inactive complex. 22377309 LncRNADisease
P-TEFb RNA-Protein regulation Regulation of P-TEFb by the d7SK snRNP is essential for the growth and differentiation of tissues required during Drosophila development. 22379134 LncRNADisease
LARP7 RNA-Protein binding LARP7 negatively regulates positive transcription elongation factor-b (p-TEFb) by binding to and stabilizing 7sk RNA. 22488152 LncRNADisease
ABO RNA-RNA regulation Promoters pU6 and p7SK proved to express high levels of siRNA activity and can be used in the experiment of silencing alpha-1,3galactosyltransferase gene. 22522162 LncRNADisease
HEXIM1 RNA-Protein binding The activity of P-TEFb is negatively regulated by an RNA-binding protein HEXIM1 in association with 7SK snRNA. 22609015 LncRNADisease