LncRNA Information
ID EL0011 Name 9530018H14Rik Aliases lncRNA-HIT
Species Mus musculus Chromosome 6 Start site N/A
End site N/A Chain N/A Exon NO. N/A
Assembly N/A Class N/A NCBI accession AK020562
Ensembl N/A Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
breast cancer qPCR, Luciferase reporter assay etc. breast cancer tissue, cell lines(NMuMG, 4T1) up-regulated expression The level of expression of lncRNA-HIT in normal breast tissue was low and gradually increased to invasive carcinoma suggesting lncRNA-HIT may play a role in tumor progression in humans. These data further support the findings demonstrating the involvement of lncRNA-HIT in EMT and invasion as observed in NMuMG and 4T1 cells, and suggest that conserved human lncRNA-HIT could play a pivotal role in breast cancer metastasis. 25605728 Lnc2Cancer
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
ChIRP-seq, siRNA-mediated reductions E 11 mouse embryos up-regulated interaction Mechanistically the LncRNA-HIT siRNA treatments impacted pro-chondrogenic gene expression by reducing H3K27ac or p100 activity, confirming that LncRNA-HIT is essential for chondrogenic differentiation in the limb mesenchyme. 26633036
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
p100 and CBP RNA-Protein binding In the limb mesenchyme, LncRNA-HIT was found to be retained in the nucleus, forming a complex with p100 and CBP. 26633036