LncRNA Information
ID EL1085 Name PRINS Aliases NCRNA00074
Species Homo sapiens Chromosome 10 Start site 24536051
End site 24544975 Chain plus Exon NO. N/A
Assembly Ensembl Release 89 Class sense no exonic NCBI accession N/A
Ensembl ENSG00000277563 Sequence N/A


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) down-regulated N/A Interestingly, nine out of these thirteen known cancer-related lncRNA showed significantly differential expression between tumor and normal prostate samples. Several lncRNA such as NEAT1, DANCR, HOTTIP, PRINS, and EGOT that have established functions in forming nuclear speckles, in development or in autoimmune disease, but were not previously known to be related to cancer, showed differential expression between tumor and normal prostate samples, suggesting their potential function in prostate cancer. 23728290 Lnc2Cancer
psoriasis N/A N/A N/A N/A PRINS is a psoriasis susceptibility-related noncoding RNA gene. 15855153 LncRNADisease
psoriasis N/A N/A N/A expression The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS. 20377629 LncRNADisease
psoriasis N/A N/A N/A expression In an effort to identify novel susceptibility factors for the hyperproliferative skin disorder psoriasis, Sonkoly et al. analyzed differential gene expression of unaffected epidermis from psoriasis patients compared to specimens from healthy subjects and identified a novel lncRNA called psoriasis susceptibility-related RNA gene induced by stress (PRINS) involved in psoriasis susceptibility 24115003 LncRNADisease
psoriasis silenced with small interfering RNA (siRNA) normal human keratinocytes (NHKs) and HaCaT cells N/A N/A PRINS expression responded differentially to various stress signals and microbial agents in HaCaT cells and in NHKs: after translational inhibition and UV-B treatment, similar induction of PRINS expression occurred with different time courses while after microbial agent treatment, the PRINS expression was significantly induced in HaCaT cells, whereas we could not detect similar changes in NHKs. Silencing of PRINS had no effect on LPS-induced NF-κB activity either in HaCaT cells or in NHKs PRINS probably affects keratinocytes functions independently of NF-κB signalling 21750967
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
N/A renal tubular cells of wild type mice up-regulated interaction Among HIF-1α dependent LncRNAs, PRINS (Psoriasis susceptibility-related RNA Gene Induced by Stress) was significantly up regulated in hypoxic conditions and had specific interaction with RANTES as confirmed through reporter assay. 26725683
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
G1P3 RNA-RNA co-expression Here, we report that PRINS regulates G1P3, a gene with anti-apoptotic effects in keratinocytes. siRNA-mediated inhibition of PRINS gene resulted in altered cell morphology and gene expression alterations, as demonstrated in a microarray experiment. 20377629 LncRNADisease
RANTES RNA-Protein regulation Among HIF-1α dependent LncRNAs, PRINS (Psoriasis susceptibility-related RNA Gene Induced by Stress) was significantly up regulated in hypoxic conditions and had specific interaction with RANTES as confirmed through reporter assay. 26725683