LncRNA Information
ID EL1077 Name linc-POU3F3 Aliases PANTR1; linc-Brn1a; linc-POU3F3
Species Homo sapiens Chromosome 2 Start site 104807572
End site 104853183 Chain minus Exon NO. 5
Assembly Ensembl Release 89 Class antisense NCBI accession NR_037883, NR_131233, NR_131234, NR_131235
Ensembl ENSG00000233639 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
glioma qPCR etc. glioma tissue, cell lines (T98G, A172) up-regulated N/A By using real-time PCR and gain-/loss-of-function studies,the authors revealed that linc-POU3F3 levels were extraordinarily associated with the tumor WHO grade.In related biochemical assays, overexpression of linc-POU3F3 promotes cell viability and proliferation in glioma cells, whereas knockdown of linc-POU3F3 showed the opposite effect. As expected, they also found that linc-POU3F3 expression was negatively correlated with the mRNA level of POU3F3. 25445282 LncRNADisease Lnc2Cancer
esophageal squamous cell carcinoma qPCR etc. blood (plasma and serum) up-regulated expression Furthermore, plasma levels of POU3F3, HNF1A-AS1 and SPRY4-IT1 were significantly higher in ESCC patients compared with normal controls.By receiver operating characteristic curve (ROC) analysis, among the three lncRNAs investigated, plasma POU3F3 provided the highest diagnostic performance for detection of ESCC (the area under the ROC curve (AUC), 0.842. 25608466 Lnc2Cancer
esophageal squamous cell carcinoma qPCR, Western blot, Luciferase reporter assay, RIP etc. ESCC tissue up-regulated N/A Levels of a lincRNA encoded by a gene located next to POU3F3 (linc-POU3F3) were significantly higher in ESCC than neighboring nontumor tissues. In RNA immunoprecipitation assays, linc-POU3F3 was associated with the EZH2 messenger RNA (mRNA). Overexpression of linc-POU3F3 in cell lines increased their proliferation and ability to form colonies, and reduced the expression of POU3F3 mRNA, whereas knockdown of linc-POU3F3 increased the levels of POU3F3 mRNA. 24631494 Lnc2Cancer