| Disease |
| Disease |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
| glioma |
qPCR etc. |
glioma tissue, cell lines (T98G, A172) |
up-regulated |
N/A |
By using real-time PCR and gain-/loss-of-function studies,the authors revealed that linc-POU3F3 levels were extraordinarily associated with the tumor WHO grade.In related biochemical assays, overexpression of linc-POU3F3 promotes cell viability and proliferation in glioma cells, whereas knockdown of linc-POU3F3 showed the opposite effect. As expected, they also found that linc-POU3F3 expression was negatively correlated with the mRNA level of POU3F3. |
25445282 |
LncRNADisease Lnc2Cancer
|
| esophageal squamous cell carcinoma |
qPCR etc. |
blood (plasma and serum) |
up-regulated |
expression |
Furthermore, plasma levels of POU3F3, HNF1A-AS1 and SPRY4-IT1 were significantly higher in ESCC patients compared with normal controls.By receiver operating characteristic curve (ROC) analysis, among the three lncRNAs investigated, plasma POU3F3 provided the highest diagnostic performance for detection of ESCC (the area under the ROC curve (AUC), 0.842. |
25608466 |
Lnc2Cancer
|
| esophageal squamous cell carcinoma |
qPCR, Western blot, Luciferase reporter assay, RIP etc. |
ESCC tissue |
up-regulated |
N/A |
Levels of a lincRNA encoded by a gene located next to POU3F3 (linc-POU3F3) were significantly higher in ESCC than neighboring nontumor tissues. In RNA immunoprecipitation assays, linc-POU3F3 was associated with the EZH2 messenger RNA (mRNA). Overexpression of linc-POU3F3 in cell lines increased their proliferation and ability to form colonies, and reduced the expression of POU3F3 mRNA, whereas knockdown of linc-POU3F3 increased the levels of POU3F3 mRNA. |
24631494 |
Lnc2Cancer
|
| |