LncRNA Information
ID	EL1070	Name	PINK1-AS	Aliases	NAPINK11; PINK1AS; PINK1-AS
Species	Homo sapiens	Chromosome	1	Start site	20642657
End site	20652193	Chain	minus	Exon NO.	3
Assembly	Ensembl Release 89	Class	antisense	NCBI accession	NR_046507
Ensembl	ENSG00000117242	Sequence

Disease
Disease	Method	Sample	Expression pattern	Dysfunction type	Description	PMID	Source
Parkinson's disease	N/A	N/A	N/A	Interaction	Mutations in the PTEN induced putative kinase 1 (PINK1) are implicated in early-onset Parkinson's disease. Welective targeting of naPINK1 results in loss of the PINK1 splice variant in neuronal cell lines.	17362513	LncRNADisease
glucose metabolism disorder	N/A	N/A	N/A	expression	As the name suggests, PINK1 is induced by PTEN, which is an important inhibitor of insulin signalling. PINK1 depletion has been associated with diabetes status, impaired glucose uptake in neuronal cell lines and with mitochondrial gene expression in adipocytes , raising the possibility that disruption to naPINK1 may impact on glucose metabolism.	22817756	LncRNADisease

Function (not disease relevant)
Methods	Sample/condition	Expression pattern	Dysfunction type	Description	PMID	Source
knockdown, qT-PCR	preadipocytes and adipocytes	down-regulated	interaction	PU.1 AS lncRNA promotes adipogenesis through preventing PU.1 mRNA translation via binding to PU.1 mRNA to form mRNA/AS lncRNA duplex in preadipocytes.	23749759

Interaction
Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
PU.1 mRNA	RNA-RNA	binding	PU.1 AS lncRNA binding to PU.1 mRNA to form mRNA/AS lncRNA duplex in preadipocytes	23749759