LncRNA Information
ID EL1049 Name PAWR Aliases PAR4; Par-4
Species Homo sapiens Chromosome 12 Start site 79574979
End site 79691097 Chain minus Exon NO. 13
Assembly Ensembl Release 89 Class processed transcript NCBI accession XR_944561, XR_944560
Ensembl ENSG00000177425 Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
acute lymphoblastic leukemia qPCR, Western blot, knockdown etc. T-ALL jurkat cell up-regulated N/A T-ALL-R-LncR1 was not observed in human normal tissues. However, an obvious expression was observed in some tumor tissues. T-ALL-R-LncR1 was markedly expressed in neoplastic T lymphocytes of 11 cases out of 21 children with T-ALL, indicating that T-ALL-R-LncR1 might be associated with T-ALL. T-ALL-R-LncR1 knockdown predisposed Jurkat cells to undergo pro-apoptotic factor Par-4-induced apoptosis. Further studies revealed that T-ALL-R-LncR1 knockdown facilitated the formation of a Par-4/THAP1 protein complex, resulting in the activation of caspase-3 and an increase of pro-apoptotic Smac protein in T-ALL cells 23906015 Lnc2Cancer