LncRNA Information | ||||||
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ID | EL1048 | Name | Paupar | Aliases | N/A | |
Species | Mus musculus | Chromosome | 2 | Start site | 105657862 | |
End site | 105660692 | Chain | minus | Exon NO. | 1 | |
Assembly | Ensembl Release 89 | Class | lincRNA | NCBI accession | NR_117095 | |
Ensembl | ENSMUSG00000102424 | Sequence |
Function (not disease relevant) | |||||||||
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Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
knockdown | N2A mouse neuroblastoma cells | N/A | N/A | Knockdown of Paupar disrupts the normal cell cycle profile of neuroblastoma cells and induces neural differentiation. Paupar acts in a transcript-dependent manner both locally, to regulate Pax6, as well as distally by binding and regulating genes on multiple chromosomes, in part through physical association with PAX6 protein. Paupar binding sites are enriched near promoters and can function as transcriptional regulatory elements whose activity is Modulated by Paupar transcript levels. | 24488179 | ||||
Interaction | |||||||||
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Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
PAX6 | RNA-Protein | binding | Paupar acts in a transcript-dependent manner both locally, to regulate Pax6, as well as distally by binding and regulating genes on multiple chromosomes, in part through physical association with PAX6 protein. Paupar binding sites are enriched near promoters and can function as transcriptional regulatory elements whose activity is Modulated by Paupar transcript levels. | 24488179 | |||||