LncRNA Information
ID EL1046 Name PANDAR Aliases PANDA
Species Homo sapiens Chromosome 6 Start site 36673621
End site 36675126 Chain minus Exon NO. 1
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_109836
Ensembl ENSG00000281450 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
breast cancer knockdown of PANDAR breast cancer tissues and cell lines up-regulated N/A PANDAR in regulating the progression of breast cancer 26927017
cancer N/A N/A N/A expression Another DNA damage-responsive, p53-induced lncRNA that lies upstream of p21, PANDA (P21 associated ncRNA DNA damage activated), is also implicated in the repression of pro-apoptotic genes, such as FAS and BIK, by acting as a decoy for the transcription factor NF-YA. In some cancer types, p53 mutations have been found that maintain the protein's ability to induce the PANDA pathway (and its antiapoptotic effects) while abolishing its ability to induce p21 and its promotion of cell-cycle arrest, thus leading to increased tumor cell survival (Hung et al. 2011). 23463798 LncRNADisease
hepatocelluar carcinoma qPCR, knockdown etc. HCC tissue, cell lines (HCCLM3, Hep3B, HepG2) up-regulated expression PANDAR was overexpressed in HCC tissues and cell lines. Moreover, its expression level was significantly correlated with liver cirrhosis, HBsAg, AFP, tumor nodule, vascular invasion and TNM stage. PANDAR overexpression was associated with poorer survival and shorter recurrence and served as an independent prognostic marker of patients with HCC. 26054684 Lnc2Cancer
non-small cell lung cancer qPCR, Western blot, RIP etc. lung cancer tissue, cell lines (A549, SPC-A1, NCI-H1299, SK-MES-1 etc.) down-regulated interaction In a cohort of 140 NSCLC patients, decreased PANDAR expression was negatively correlated with greater tumor size (P<0.001) and advanced TNM stage (P=0.002). Moreover, PANDAR could serve as an independent predictor for overall survival in NSCLC (P=0.015). PANDAR-mediated growth regulation is in part due to the transcriptional modulation of Bcl-2 by interacting with NF-YA, thus affecting NSCLC cell apoptosis. 25719249 Lnc2Cancer
gastric cancer Quantitative Real-time PCR 100 paired gastric cancer tissues up-regulated N/A high expression of PANDAR was correlated with depth of invasion, TNM stage and lymphatic metastasis 26898439
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
N/A N/A N/A expression Biogenesis, metabolism, and functions of lncRNAs are otherwise interconnected with known pathogenic mechanisms 23791884 LncRNADisease
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
Bcl-2 RNA-DNA regulation PANDAR-mediated growth regulation is in part due to the transcriptional modulation of Bcl-2 by interacting with NF-YA, thus affecting NSCLC cell apoptosis. 25719249