| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL1044 | Name | PACERR | Aliases | PACER; PTGS2-AS1 | |
| Species | Homo sapiens | Chromosome | 1 | Start site | 186680622 | |
| End site | 186681446 | Chain | plus | Exon NO. | 1 | |
| Assembly | Ensembl Release 89 | Class | lincRNA | NCBI accession | NR_125801 | |
| Ensembl | ENSG00000273129 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| cancer | ChIP, qPCR, RACE | primary human mammary epithelial cells and monocyte/macrophage cell lines | N/A | interaction | The lncRNA associates with p50, a repressive subunit of NF-κB, and occludes it from the COX-2 promoter, potentially facilitating interaction with activation-competent NF-κB p65/p50 dimers. | 24843008 | |||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| NF-κB complexes | RNA-Protein | regulation | The lncRNA associates with p50, a repressive subunit of NF-κB, and occludes it from the COX-2 promoter, potentially facilitating interaction with activation-competent NF-κB p65/p50 dimers. | 24843008 | |||||