| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL1034 | Name | P2rx3 | Aliases | N/A | |
| Species | Rattus norvegicus | Chromosome | 3 | Start site | 72403993 | |
| End site | 72447801 | Chain | minus | Exon NO. | 13 | |
| Assembly | Ensembl Release 89 | Class | N/A | NCBI accession | NR_073054 | |
| Ensembl | ENSRNOG00000008552 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| type 2 diabetes mellitus | rat lncRNA array profiling | type 2 diabetic rats | up-regulated | N/A | lncRNA uc.48+ siRNA regulating the expression of P2X7 and ERK signaling in SCG. | 27118262 | |||
| diabetes mellitus | reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry, and western blotting | diabetic rat dorsal root ganglia (DRG) Diabetes mellitus (DM) patients' serum samples | up-regulated | interaction | Uc.48+ siRNA treatment may alleviate the DNP by inhibiting the excitatory transmission mediated by the P2X3 receptor in DRG. | 26686228 | |||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| TNF-α | RNA-Protein | regulation | The expression levels of TNF-α in the DRG of DM rats treated with uc.48+ siRNA were significantly decreased compared to those in the DM group. | 26686228 | |||||
| P2X3 | RNA-DNA | regulation | The levels of P2X3 protein and mRNA in the DG of DM rats treated with uc.48+ siRNA were significantly decreased compared to those in DM rats. | 26686228 | |||||
| ERK1/2 | RNA-Protein | regulation | The phosphorylation and activation of ERK1/2 in the DM DRG were decreased by uc.48+ siRNA treatment. | 26686228 | |||||