| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL1020 | Name | OIP5-AS1 | Aliases | cyrano | |
| Species | Homo sapiens | Chromosome | 15 | Start site | 41283990 | |
| End site | 41309737 | Chain | plus | Exon NO. | 4 | |
| Assembly | Ensembl Release 89 | Class | antisense | NCBI accession | NR_026757 | |
| Ensembl | ENSG00000247556 | Sequence | ||||
| Function (not disease relevant) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
| N/A | human cervical carcinoma HeLa cells | N/A | interaction | OIP5-AS1 reduces cell proliferation. OIP5-AS1 serves as a sponge or a competing endogenous (ce)RNA for HuR, restricting its availability to HuR target mRNAs and thereby repressing HuR-elicited proliferative phenotypes. | 26819413 | ||||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| miR-424 | RNA-RNA | regulation | miR-424 interacted with OIP5-AS1 and competed with HuR for binding to OIP5-AS1 | 26819413 | |||||
| HuR | RNA-Protein | binding | The RNA-binding protein HuR, which enhances cell proliferation, associated with OIP5-AS1 and stabilized it. Tagging OIP5-AS1 with MS2 hairpins to identify associated microRNAs revealed that miR-424 interacted with OIP5-AS1 and competed with HuR for binding to OIP5-AS1. | 26819413 | |||||