LncRNA Information
ID	EL1013	Name	NRON	Aliases	NCRNA00194
Species	Homo sapiens	Chromosome	9	Start site	126407775
End site	126410504	Chain	minus	Exon NO.	1
Assembly	GRCh38.p7	Class	N/A	NCBI accession	NR_045006
Ensembl	N/A	Sequence

Disease
Disease	Method	Sample	Expression pattern	Dysfunction type	Description	PMID	Source
Down's syndrome	N/A	N/A	N/A	expression	NRON is a lncRNA that mediates the cytoplasmic to nuclear shuttling of the NFAT transcription factor . In animal models, deregulation of the DSCR1 and DYRK1A genes act synergistically to prevent nuclear occupancy of NFATc transcription factors leading to reduced NFATc activity and to many features of DS, suggesting a potential link between NRON activity and DS pathophysiology.	16141075	LncRNADisease
AIDS	N/A	N/A	N/A	N/A	The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins. Its expression was significantly altered following HIV-1 infection. Its levels were reduced by the early viral accessory protein Nef and increased by the late protein Vpu.	25728138	LncRNADisease

Interaction
Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
NFAT	RNA-Protein	regulation	By binding to members of the nucleocytoplasmic trafficking machinery, NRON specifically inhibits the nuclear accumulation of NFAT.	19571179	LncRNADisease
NFAT	RNA-Protein	regulation	The conserved lncRNA, named NRON,regulated the nucleocytoplasmic shuttling of the NFAT transcription factor by functioning in a nuclear pore ribonucleoprotein complex.	20951849	LncRNADisease
LRRK2	RNA-Protein	binding	Mechanistic studies showed that LRRK2 was a potent negative regulator of the transcription factor NFAT and was a component of a complex that included the large noncoding RNA NRON.	21983832	LncRNADisease