LncRNA Information
ID EL1013 Name NRON Aliases NCRNA00194
Species Homo sapiens Chromosome 9 Start site 126407775
End site 126410504 Chain minus Exon NO. 1
Assembly GRCh38.p7 Class N/A NCBI accession NR_045006
Ensembl N/A Sequence

Disease Method Sample Expression pattern Dysfunction type Description PMID Source
Down's syndrome N/A N/A N/A expression NRON is a lncRNA that mediates the cytoplasmic to nuclear shuttling of the NFAT transcription factor . In animal models, deregulation of the DSCR1 and DYRK1A genes act synergistically to prevent nuclear occupancy of NFATc transcription factors leading to reduced NFATc activity and to many features of DS, suggesting a potential link between NRON activity and DS pathophysiology. 16141075 LncRNADisease
AIDS N/A N/A N/A N/A The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins. Its expression was significantly altered following HIV-1 infection. Its levels were reduced by the early viral accessory protein Nef and increased by the late protein Vpu. 25728138 LncRNADisease

Interaction target Level of interaction Type of interaction Description PMID Source
NFAT RNA-Protein regulation By binding to members of the nucleocytoplasmic trafficking machinery, NRON specifically inhibits the nuclear accumulation of NFAT. 19571179 LncRNADisease
NFAT RNA-Protein regulation The conserved lncRNA, named NRON,regulated the nucleocytoplasmic shuttling of the NFAT transcription factor by functioning in a nuclear pore ribonucleoprotein complex. 20951849 LncRNADisease
LRRK2 RNA-Protein binding Mechanistic studies showed that LRRK2 was a potent negative regulator of the transcription factor NFAT and was a component of a complex that included the large noncoding RNA NRON. 21983832 LncRNADisease