| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL1010 | Name | NRAV | Aliases | DYNLL1-AS1; DYNLL1AS1 | |
| Species | Homo sapiens | Chromosome | 12 | Start site | 120490328 | |
| End site | 120495940 | Chain | minus | Exon NO. | 2 | |
| Assembly | Ensembl Release 89 | Class | antisense | NCBI accession | NR_038854 | |
| Ensembl | ENSG00000248008 | Sequence | ||||
| Function (not disease relevant) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
| overexpression | human cells or transgenic mice | down-regulated | expression | A lncRNA that we call negative regulator of antiviral response (NRAV) was dramatically downregulated during infection with several viruses, we ectopically expressed NRAV in human cells or transgenic mice and found that it significantly promotes influenza A virus (IAV) replication and virulence. | 25525793 | ||||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| interferon-stimulated genes (ISGs) | RNA-DNA | regulation | NRAV negatively regulates the initial transcription of multiple critical interferon-stimulated genes (ISGs), including IFITM3 and MxA, by affecting histone modification of these genes. | 25525793 | |||||