INTERACTION
ID	lncRNA Name	Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
EL1459	XIST	H3	RNA-Protein	regulation	The concentration of PRC2 at the 59 end of Xist is intriguing because recruitment of PRC2 and H3-K27me3 are two of the earliest changes to occur on the X following Xist up-regulation.	19684108	LncRNADisease
EL1459	XIST	PRC2	RNA-Protein	binding	During female development, Xist RNA is expressed from the inactive X and coats the X chromosome from which it is transcribed, leading to recruitment of Polycomb repressive complex 2 (PRC2), which trimethylates histone H3 at lysine 27 to silence transcription.	21496640	LncRNADisease
EL1459	XIST	miR-152	RNA-RNA	regulation	miR-152 mediated the tumor-suppressive effects that knockdown of XIST exerted.	25578780
EL1460	Xist	Hprt	RNA-DNA	regulation	Loss of xist rna destabilizes the inactive state in somatic cells, leading to an increased reactivation frequency of an x-linked gfp transgene and of the endogenous hypoxanthine phosphoribosyl transferase (hprt) gene in mouse embryonic fibroblasts.	11352938
EL1460	Xist	H2A	RNA-Protein	binding	The association of the xi with macro-histone h2a is also disturbed by pna interference mapping.	11481485
EL1460	Xist	TAP/NXF1	RNA-Protein	binding	The export factor TAP/NXF1 binds poorly to XIST RNA in comparison to exported mRNAs, suggesting that reduced TAP/NFX1 binding may contribute to nuclear retention of XIST RNA.	17333237	LncRNADisease
EL1460	Xist	Dicer	RNA-DNA	binding	In the absence of Dicer, coating by Xist RNA, initiation of silencing, and recruitment of Polycomb proteins occur normally	19164542
EL1460	Xist	PRC2	RNA-Protein	binding	A large noncoding RNA encoded within the 5 of XIST that can target PRC2 to the inactive X chromosome.	19571010	LncRNADisease
EL1460	Xist	PRC2	RNA-Protein	binding	The concentration of PRC2 at the 59 end of Xist is intriguing because recruitment of PRC2 and H3-K27me3 are two of the earliest changes to occur on the X following Xist up-regulation.	19684108	LncRNADisease
EL1460	Xist	HNRNPU	RNA-Protein	binding	Xist RNA and hnRNP U interact and upon depletion of hnRNP U, Xist RNA is detached from the Xi and diffusely localized into the nucleoplasm.	20833368	LncRNADisease
EL1460	Xist	SAF-A	RNA-Protein	binding	SAF-A is a plausible candidate for an anchor point of the Xist nrRNA to inactive X-chromosomes.	20940252	LncRNADisease
EL1460	Xist	Rnf12	RNA-RNA	co-expression	Overexpression of Rnf12 ectopically induces Xist expression in XY cells.	21029862	LncRNADisease
EL1460	Xist	PRC2	RNA-Protein	binding	Tsix represses Xist induction by several means, including altering the chromatin state of Xist, deploying Dnmt3a’s DNA methyltransferase activity, recruiting the RNAi machinery, and interfering with the ability of Xist and RepA RNA to engage Polycomb proteins.	21029862	LncRNADisease
EL1460	Xist	PRC2	RNA-Protein	binding	X chromosome inactivation requires Xist, an ncRNA that coats the X and recruits Polycomb proteins.	21029862	LncRNADisease
EL1460	Xist	Ezh2	RNA-Protein	binding	Ezh2 interacts with HOTAIR and Xist.	21123648	LncRNADisease
EL1460	Xist	PRC2	RNA-Protein	binding	CDK1 and CDK2 phosphorylate EZH2 at threonine 350 (T350) and that T350 phosphorylation is important for the binding of EZH2 to PRC2 recruiters, such as noncoding RNAs (ncRNAs) HOTAIR and XIST.	21278485	LncRNADisease
EL1460	Xist	YY1	RNA-Protein	binding	Here, we define the nucleation center for Xist RNA and show that YY1 docks Xist particles onto the X chromosome.	21729784	LncRNADisease
EL1460	Xist	HNRNPU	RNA-Protein	binding	Xist RNA and hnRNP U interact, and depletion of hnRNP U causes Xist to detach from the Xi and to localize diffusely in the nucleoplasm.	21925379	LncRNADisease
EL1460	Xist	EZH2	RNA-Protein	binding	HOTAIR, Kcnq1ot and Xist all mediate their effects by interacting with the Polycomb-repressive complex 2 (PRC2) component Ezh2 (enhancer of zeste homolog 2 (Drosophila)) and modulating histone methylation.	21936910	LncRNADisease