INTERACTION |
ID |
lncRNA Name |
Interaction target |
Level of interaction |
Type of interaction |
Description |
PMID |
Source |
EL1431 |
UCA1 |
171. C/EBPα-p30 |
RNA-Protein |
regulation |
we identified the oncogenic urothelial carcinoma associated 1 (UCA1) lncRNA as a novel target of the C/EBPα-p30. |
26053097 |
|
EL1431 |
UCA1 |
Hyaluronoglucosaminidase 1 (HYAL1) |
RNA-Protein |
co-expression |
There was a significant positive correlation between HYAL1 and the selected epigenetic biomarkers. |
26138586 |
|
EL1431 |
UCA1 |
AKT/mTOR pathway |
N/A |
regulation |
UCA1 may induce non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway and EMT. |
26160838 |
|
EL1431 |
UCA1 |
Ets-2 |
DNA-Protein |
binding |
Ets-2 bound to the UCA1 core promoter using luciferase assays. |
26238511 |
|
EL1431 |
UCA1 |
β-catenin |
RNA-Protein |
regulation |
CUDR causes highly upregulated in liver cancer (HULC) and β-catenin abnormal expression by inhibiting HULC promoter methylation and promoting β-catenin promoter-enhancer chromatin looping formation mediated by CUDR-ccctc-binding factor (CTCF) complex, which recruits more RNA polII and P300. |
26347501 |
|
EL1431 |
UCA1 |
histone H3 twenty-seventh lysine (H3K27me3) |
RNA-Protein |
regulation |
CUDR could enhance the human embryonic stem cells (ESC) differentiation into hepatocyte-like cells by reducing trimethylation on histone H3 twenty-seventh lysine (H3K27me3). |
26347501 |
|
EL1431 |
UCA1 |
miR-16 |
RNA-RNA |
regulation |
Urothelial carcinoma-associated 1 regulated the expression of GLS2 through interfering with miR-16, and repressed ROS formation in bladder cancer cells. |
26373319 |
|
EL1431 |
UCA1 |
miR-143 |
RNA-RNA |
binding |
There are direct interactions between miR-143 and the miRNA recognition sites of UCA1. UCA1 is present in Ago2-containing RNA-induced silencing complex (RISC), through association with miR-143. |
26439035 |
|
EL1431 |
UCA1 |
H19 |
RNA-DNA |
binding |
CUDR-CyclinD1 complex loads onto the long noncoding RNA H19 promoter region that may lead to reduce the DNA methylation on H19 promoter region and then to enhance the H19 expression. |
26513297 |
|
EL1431 |
UCA1 |
C-myc |
RNA-DNA |
binding |
Insulator CTCF recruits the CUDR-CyclinD1 complx to form the composite CUDR-CyclinD1-insulator CTCF complex which occupancied on the C-myc gene promoter region, increasing the outcome of oncogene C-myc. |
26513297 |
|
EL1431 |
UCA1 |
CyclinD1 |
RNA-Protein |
binding |
The decrease of PTEN in cells may lead to increase binding capacity of CUDR to CyclinD1. |
26513297 |
|
EL1431 |
UCA1 |
ZEB1 and ZEB2 |
RNA-Protein |
regulation |
lncRNA-UCA1 induced EMT of bladder cancer cells by upregulating the expression levels of zinc finger E-box binding homeobox 1 and 2 (ZEB1 and ZEB2) |
26544536 |
|
EL1431 |
UCA1 |
hsa-miR-145 |
RNA-RNA |
binding |
The binding site for hsa-miR-145 within exons 2 and 3 of lncRNA-UCA1 contributed to the reciprocal negative regulation of lncRNA-UCA1 and hsa-miR-145. |
26544536 |
|
EL1431 |
UCA1 |
KLF4 |
RNA-Protein |
regulation |
UCA1 loss-of-function could decrease KLF4 expression, subsequently, the downregulation of KRT6 and KRT13. |
26550172 |
|
EL1431 |
UCA1 |
SET1A |
RNA-Protein |
regulation |
SET1A cooperates with CUDR to play a positive potential role during hepatocarcinogenesis and hepatocyte-like stem cells' malignant transformation epigenetically |
26581161 |
|
EL1431 |
UCA1 |
miR-193a-3p |
RNA-RNA |
binding |
UCA1 upregulated the expression of miR-193a-3p target gene ERBB4 through competitively 'spongeing' miR-193a-3p. |
26655272 |
|
EL1431 |
UCA1 |
MMP14 |
RNA-Protein |
regulation |
Depletion of UCA1 was involved in the downregulation of matrix metallopeptidase 14 (MMP14) expression, a target gene of miR-485-5p. |
26867765 |
|
EL1431 |
UCA1 |
miR-485-5p |
RNA-RNA |
binding |
UCA1 could function as an endogenous sponge by directly binding to miR-485-5p. |
26867765 |
|
EL1431 |
UCA1 |
CREB1 |
RNA-Protein |
regulation |
CREB1 as a new target of miR-204-5p. The protein levels of CREB1 were significantly up-regulated in CRCs, negatively associated with survival time and positively correlated with the UCA1 expression. |
27046651 |
|
EL1431 |
UCA1 |
miR-204-5p |
RNA-RNA |
binding |
UCA1 could sponge endogenous miR-204-5p and inhibit its activity. |
27046651 |
|
|