ID lncRNA Name Interaction target Level of interaction Type of interaction Description PMID Source
EL1431 UCA1 171. C/EBPα-p30 RNA-Protein regulation we identified the oncogenic urothelial carcinoma associated 1 (UCA1) lncRNA as a novel target of the C/EBPα-p30. 26053097
EL1431 UCA1 Hyaluronoglucosaminidase 1 (HYAL1) RNA-Protein co-expression There was a significant positive correlation between HYAL1 and the selected epigenetic biomarkers. 26138586
EL1431 UCA1 AKT/mTOR pathway N/A regulation UCA1 may induce non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway and EMT. 26160838
EL1431 UCA1 Ets-2 DNA-Protein binding Ets-2 bound to the UCA1 core promoter using luciferase assays. 26238511
EL1431 UCA1 β-catenin RNA-Protein regulation CUDR causes highly upregulated in liver cancer (HULC) and β-catenin abnormal expression by inhibiting HULC promoter methylation and promoting β-catenin promoter-enhancer chromatin looping formation mediated by CUDR-ccctc-binding factor (CTCF) complex, which recruits more RNA polII and P300. 26347501
EL1431 UCA1 histone H3 twenty-seventh lysine (H3K27me3) RNA-Protein regulation CUDR could enhance the human embryonic stem cells (ESC) differentiation into hepatocyte-like cells by reducing trimethylation on histone H3 twenty-seventh lysine (H3K27me3). 26347501
EL1431 UCA1 miR-16 RNA-RNA regulation Urothelial carcinoma-associated 1 regulated the expression of GLS2 through interfering with miR-16, and repressed ROS formation in bladder cancer cells. 26373319
EL1431 UCA1 miR-143 RNA-RNA binding There are direct interactions between miR-143 and the miRNA recognition sites of UCA1. UCA1 is present in Ago2-containing RNA-induced silencing complex (RISC), through association with miR-143. 26439035
EL1431 UCA1 H19 RNA-DNA binding CUDR-CyclinD1 complex loads onto the long noncoding RNA H19 promoter region that may lead to reduce the DNA methylation on H19 promoter region and then to enhance the H19 expression. 26513297
EL1431 UCA1 C-myc RNA-DNA binding Insulator CTCF recruits the CUDR-CyclinD1 complx to form the composite CUDR-CyclinD1-insulator CTCF complex which occupancied on the C-myc gene promoter region, increasing the outcome of oncogene C-myc. 26513297
EL1431 UCA1 CyclinD1 RNA-Protein binding The decrease of PTEN in cells may lead to increase binding capacity of CUDR to CyclinD1. 26513297
EL1431 UCA1 ZEB1 and ZEB2 RNA-Protein regulation lncRNA-UCA1 induced EMT of bladder cancer cells by upregulating the expression levels of zinc finger E-box binding homeobox 1 and 2 (ZEB1 and ZEB2) 26544536
EL1431 UCA1 hsa-miR-145 RNA-RNA binding The binding site for hsa-miR-145 within exons 2 and 3 of lncRNA-UCA1 contributed to the reciprocal negative regulation of lncRNA-UCA1 and hsa-miR-145. 26544536
EL1431 UCA1 KLF4 RNA-Protein regulation UCA1 loss-of-function could decrease KLF4 expression, subsequently, the downregulation of KRT6 and KRT13. 26550172
EL1431 UCA1 SET1A RNA-Protein regulation SET1A cooperates with CUDR to play a positive potential role during hepatocarcinogenesis and hepatocyte-like stem cells' malignant transformation epigenetically 26581161
EL1431 UCA1 miR-193a-3p RNA-RNA binding UCA1 upregulated the expression of miR-193a-3p target gene ERBB4 through competitively 'spongeing' miR-193a-3p. 26655272
EL1431 UCA1 MMP14 RNA-Protein regulation Depletion of UCA1 was involved in the downregulation of matrix metallopeptidase 14 (MMP14) expression, a target gene of miR-485-5p. 26867765
EL1431 UCA1 miR-485-5p RNA-RNA binding UCA1 could function as an endogenous sponge by directly binding to miR-485-5p. 26867765
EL1431 UCA1 CREB1 RNA-Protein regulation CREB1 as a new target of miR-204-5p. The protein levels of CREB1 were significantly up-regulated in CRCs, negatively associated with survival time and positively correlated with the UCA1 expression. 27046651
EL1431 UCA1 miR-204-5p RNA-RNA binding UCA1 could sponge endogenous miR-204-5p and inhibit its activity. 27046651