| INTERACTION | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||
| EL1241 | SRA1 | mPus1p | RNA-Protein | regulation | Mpus1p-coactivator function required sra, mpus1p-associated mrargamma binding, and pus activities. | 15327771 | |||
| EL1241 | SRA1 | MyoD | RNA-Protein | binding | We have found that the RNA helicases p68/p72 are MyoD-associated proteins and that the noncoding RNA SRA also immunoprecipitates with MyoD. | 17011493 | LncRNADisease | ||
| EL1241 | SRA1 | p68 | RNA-Protein | binding | One of the RNAs associated with p68/p72 is the noncoding Steroid Receptors RNA Activator (SRA). | 17495528 | LncRNADisease | ||
| EL1241 | SRA1 | p72 | RNA-Protein | binding | One of the RNAs associated with p68/p72 is the noncoding Steroid Receptors RNA Activator (SRA). | 17495528 | LncRNADisease | ||
| EL1241 | SRA1 | CCL20 | RNA-Protein | binding | Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). | 20219889 | LncRNADisease | ||
| EL1241 | SRA1 | DIO2 | RNA-Protein | binding | Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). | 20219889 | LncRNADisease | ||
| EL1241 | SRA1 | SLC2A12 | RNA-Protein | binding | Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). | 20219889 | LncRNADisease | ||
| EL1241 | SRA1 | SLC2A3 | RNA-Protein | binding | Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). | 20219889 | LncRNADisease | ||
| EL1241 | SRA1 | TBL1X | RNA-Protein | binding | Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). | 20219889 | LncRNADisease | ||
| EL1241 | SRA1 | TGFB2 | RNA-Protein | binding | Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). | 20219889 | LncRNADisease | ||
| EL1241 | SRA1 | TMEM65 | RNA-Protein | binding | Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). | 20219889 | LncRNADisease | ||
| EL1241 | SRA1 | TMPRSS2 | RNA-Protein | binding | Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2). | 20219889 | LncRNADisease | ||
| EL1241 | SRA1 | SHARP | RNA-DNA | regulation | SRA is sequestered by the transcriptionally silent TRa2 to a repressive protein complex containing RNA-binding proteins SHARP and SLIRP. | 20573714 | LncRNADisease | ||
| EL1241 | SRA1 | SLIRP | RNA-DNA | regulation | SRA is sequestered by the transcriptionally silent TRa2 to a repressive protein complex containing RNA-binding proteins SHARP and SLIRP. | 20573714 | LncRNADisease | ||
| EL1241 | SRA1 | TRa2 | RNA-Protein | binding | SRA is sequestered by the transcriptionally silent TRa2 to a repressive protein complex containing RNA-binding proteins SHARP and SLIRP. | 20573714 | LncRNADisease | ||
| EL1241 | SRA1 | SRC1 | RNA-Protein | binding | SRC1 complex is recruited by SRA. | 20573714 | LncRNADisease | ||
| EL1241 | SRA1 | MyoD | RNA-RNA | co-expression | SRA ncRNA is known to increase the activity of a range of nuclear receptors as well as the master regulator of muscle differentiation MyoD. | 20855289 | LncRNADisease | ||
| EL1241 | SRA1 | CTCF | RNA-Protein | binding | Here we showed that the DEAD-box RNA helicase p68 (DDX5) and its associated noncoding RNA, steroid receptor RNA activator (SRA), form a complex with CTCF that is essential for insulator function. | 20966046 | LncRNADisease | ||
| EL1241 | SRA1 | p68 | RNA-Protein | binding | Here we showed that the DEAD-box RNA helicase p68 (DDX5) and its associated noncoding RNA, steroid receptor RNA activator (SRA), form a complex with CTCF that is essential for insulator function. | 20966046 | LncRNADisease | ||
| EL1241 | SRA1 | IGF2 | RNA-RNA | co-expression | In vivo depletion of SRA or p68 reduced CTCF-mediated insulator activity at the IGF2/H19 ICR, increased levels of IGF2 expression, and increased interactions between the endodermal enhancer and IGF2 promoter. | 20966046 | LncRNADisease | ||
| EL1241 | SRA1 | cohesin complex | RNA-Protein | binding | p68/SRA also interacts with members of the cohesin complex. | 20966046 | LncRNADisease | ||
| EL1241 | SRA1 | PPARG | RNA-Protein | binding | We show that the non-coding RNA, Steroid receptor RNA Activator (SRA), associates with PPARgamma and coactivates PPARgamma-dependent reporter gene expression. | 21152033 | LncRNADisease | ||
| EL1241 | SRA1 | CTCF | RNA-Protein | binding | DEAD-box RNA helicase p68 (DDX5) and its associated lncRNA, SRA (steroid receptor RNA activator), form a complex with CTCF. CTCF binds to specific genomic binding sequences and plays an important role in transcriptional insulation and long-range physical interaction with other CTCF sites. | 21496640 | LncRNADisease | ||
| EL1241 | SRA1 | DDX5 | RNA-Protein | binding | DEAD-box RNA helicase p68 (DDX5) and its associated lncRNA, SRA (steroid receptor RNA activator), form a complex with CTCF. CTCF binds to specific genomic binding sequences and plays an important role in transcriptional insulation and long-range physical interaction with other CTCF sites. | 21496640 | LncRNADisease | ||
| EL1241 | SRA1 | Cisplatin and paclitaxel | N/A | regulation | Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs. | 25257554 | |||
| EL1241 | SRA1 | NANOG | RNA-TF | regulation | NANOG was identified as a transcription factor directly interacting with SRA and co-localizing with it genome-wide in NTERA2. | 26496121 | |||
| EL1241 | SRA1 | polycomb repressive complex 2 (PRC2) | RNA-Protein | binding | The lncRNA steroid receptor RNA activator (SRA) participates in regulation through complex formation with trithorax group (TrxG) and polycomb repressive complex 2 (PRC2) complexes. Binding of the SRA-associated RNA helicase p68 preferentially stabilizes complex formation between SRA and a TrxG complex but not PRC2. In human pluripotent stem cells NTERA2, SRA binding sites that are also occupied by p68 are significantly enriched for H3K4 trimethylation. | 26496121 | |||
| EL1241 | SRA1 | trithorax group (TrxG) | RNA-Protein | binding | The lncRNA steroid receptor RNA activator (SRA) participates in regulation through complex formation with trithorax group (TrxG) and polycomb repressive complex 2 (PRC2) complexes. Binding of the SRA-associated RNA helicase p68 preferentially stabilizes complex formation between SRA and a TrxG complex but not PRC2. In human pluripotent stem cells NTERA2, SRA binding sites that are also occupied by p68 are significantly enriched for H3K4 trimethylation. | 26496121 | |||