INTERACTION |
ID |
lncRNA Name |
Interaction target |
Level of interaction |
Type of interaction |
Description |
PMID |
Source |
EL1112 |
RepA |
PRC2 |
RNA-Protein |
binding |
We discovered a 1.6-kilobase ncRNA (RepA) within Xist and identified the Polycomb complex, PRC2, as its direct target. |
18974356 |
LncRNADisease
|
EL1112 |
RepA |
Ezh2 |
RNA-Protein |
regulation |
Recently, it was shown that a segment of the Xist RNA (called RepA) is important for the targeting of Ezh2 (a component of PRC2) and hence H3K27me3 to the X chromosome. |
19239885 |
LncRNADisease
|
EL1112 |
RepA |
PRC2 |
RNA-Protein |
binding |
RepA is sufficient to recruit PRC2 to chromatin in vivo. |
19571179 |
LncRNADisease
|
EL1112 |
RepA |
PRC2 |
RNA-Protein |
binding |
Tsix represses Xist induction by several means, including altering the chromatin state of Xist, deploying Dnmt3a’s DNA methyltransferase activity, recruiting the RNAi machinery, and interfering with the ability of Xist and RepA RNA to engage Polycomb proteins. |
21029862 |
LncRNADisease
|
EL1112 |
RepA |
XIST |
RNA-DNA |
regulation |
Recruits PRC2 to the inactive X chromosome in mammals. Necessary for initiation of Xist upregulation and X chromosome silencing. |
21256239 |
LncRNADisease
|
EL1112 |
RepA |
PRC2 |
RNA-Protein |
binding |
Recruits PRC2 to the inactive X chromosome in mammals. Necessary for initiation of Xist upregulation and X chromosome silencing. |
21256239 |
LncRNADisease
|
|