INTERACTION
ID lncRNA Name Interaction target Level of interaction Type of interaction Description PMID Source
EL1112 RepA PRC2 RNA-Protein binding We discovered a 1.6-kilobase ncRNA (RepA) within Xist and identified the Polycomb complex, PRC2, as its direct target. 18974356 LncRNADisease
EL1112 RepA Ezh2 RNA-Protein regulation Recently, it was shown that a segment of the Xist RNA (called RepA) is important for the targeting of Ezh2 (a component of PRC2) and hence H3K27me3 to the X chromosome. 19239885 LncRNADisease
EL1112 RepA PRC2 RNA-Protein binding RepA is sufficient to recruit PRC2 to chromatin in vivo. 19571179 LncRNADisease
EL1112 RepA PRC2 RNA-Protein binding Tsix represses Xist induction by several means, including altering the chromatin state of Xist, deploying Dnmt3a’s DNA methyltransferase activity, recruiting the RNAi machinery, and interfering with the ability of Xist and RepA RNA to engage Polycomb proteins. 21029862 LncRNADisease
EL1112 RepA XIST RNA-DNA regulation Recruits PRC2 to the inactive X chromosome in mammals. Necessary for initiation of Xist upregulation and X chromosome silencing. 21256239 LncRNADisease
EL1112 RepA PRC2 RNA-Protein binding Recruits PRC2 to the inactive X chromosome in mammals. Necessary for initiation of Xist upregulation and X chromosome silencing. 21256239 LncRNADisease