INTERACTION
ID	lncRNA Name	Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
EL1120	RN7SK	P-TEFb	RNA-Protein	regulation	7sk inhibits general and hiv-1 tat-specific transcriptional activities of p-tefb in vivo and in vitro by inhibiting the kinase activity of cdk9 and preventing recruitment of p-tefb to the hiv-1 promoter.	11713532
EL1120	RN7SK	P-TEFb	RNA-Protein	binding	The transcription-dependent interaction of p-tefb with 7sk may therefore contribute to an important feedback loop modulating the activity of rna pol ii.	11713533
EL1120	RN7SK	HEXIM1	RNA-Protein	binding	Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.	15201869	LncRNADisease
EL1120	RN7SK	OCT1	DNA-TF	regulation	PTF and Oct-1 enhance transcription from the 7SK promoter in an interdependent manner.	1535687	LncRNADisease
EL1120	RN7SK	PTF	DNA-TF	regulation	PTF and Oct-1 enhance transcription from the 7SK promoter in an interdependent manner.	1535687	LncRNADisease
EL1120	RN7SK	HEXIM1	RNA-Protein	binding	7SK RNA binding to a HEXIM1 multimer promotes the simultaneous recruitment and hence inactivation of multiple P-TEFb units.	15994294	LncRNADisease
EL1120	RN7SK	APOBEC3C	RNA-Protein	binding	it is unclear how APOBEC3C's activity is controlled to prevent its mutations of genomic DNA. We show that most of APOBEC3C interact with about half of nuclear 7SK, which suppresses APOBEC3C's deaminase activity and sequesters APOBEC3C in the nucleolus where it could be at a safe distance from most genomic sequences.	17381310
EL1120	RN7SK	BCDIN3	RNA-Protein	regulation	BCDIN3 is the 7SK snRNA methylphosphate capping enzyme (MePCE) present in an snRNP complex containing both RNA processing and transcription factors, including the elongation factor P-TEFb.	17643375	LncRNADisease
EL1120	RN7SK	HEXIM1	RNA-Protein	binding	When associated with 7SK small nuclear RNA, HEXIM1 binds to P-TEFb and inhibits the kinase activity of P-TEFb.	17671421	LncRNADisease
EL1120	RN7SK	LARP7	RNA-Protein	binding	PIP7S binds and stabilizes nearly all the nuclear 7SK via 3'-UUU-OH, leading to the sequestration and inactivation of P-TEFb.	18249148	LncRNADisease
EL1120	RN7SK	LARP7	RNA-Protein	binding	LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated.	18281698	LncRNADisease
EL1120	RN7SK	HEXIM1	RNA-Protein	binding	HEXIM1 suppresses transcription elongation via sequestration of positive transcription elongation factor b (P-TEFb) using 7SK RNA as a scaffold.	18407829	LncRNADisease
EL1120	RN7SK	PP1a	RNA-Protein	regulation	PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling.	18483222	LncRNADisease
EL1120	RN7SK	PP2B	RNA-Protein	regulation	PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling.	18483222	LncRNADisease
EL1120	RN7SK	LARP7	RNA-Protein	binding	The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes.	18483487	LncRNADisease
EL1120	RN7SK	HEXIM1	RNA-Protein	binding	Dissociation of 7SK and HEXIM1 from P-TEFb promotes P-TEFb kinase activity, and thus enhances Pol II elongation	19239885	LncRNADisease
EL1120	RN7SK	P-TEFb	RNA-Protein	regulation	Dissociation of 7SK and HEXIM1 from P-TEFb promotes P-TEFb kinase activity, and thus enhances Pol II elongation.	19239885	LncRNADisease
EL1120	RN7SK	HEXIM1	RNA-Protein	binding	The Hexim1 binding site is located in the 24-87 region of 7SK RNA and that the protein residues outside the basic domain of Hexim1 are involved in specific RNA interactions.	19244621	LncRNADisease
EL1120	RN7SK	hLARP7	RNA-Protein	binding	7SK snRNP assembly by hLARP7/PIP7S	20138158	LncRNADisease
EL1120	RN7SK	PIP7S	RNA-Protein	binding	7SK snRNP assembly by hLARP7/PIP7S	20138158	LncRNADisease
EL1120	RN7SK	Tat	RNA-Protein	binding	HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP.	20471949	LncRNADisease
EL1120	RN7SK	HEXIM1	RNA-Protein	binding	HEXIM1 targets a repeated GAUC motif in the riboregulator of transcription 7SK and promotes base pair rearrangements.	20675720	LncRNADisease
EL1120	RN7SK	HEXIM1	RNA-Protein	binding	Although HEXIM1 binds tightly to 7SK RNA in vitro, release of P-TEFb from the 7SK snRNP is accompanied by the loss of HEXIM1.	20808803	LncRNADisease
EL1120	RN7SK	P-TEFb	RNA-Protein	binding	Tat has been shown to bind 7SK directly and recruit P-TEFb to TAR.	20816986	LncRNADisease
EL1120	RN7SK	HEXIM1	RNA-Protein	binding	Human T-lymphotropic virus type 1 Tax protein complexes with P-TEFb and competes for Brd4 and 7SK snRNP/HEXIM1 binding. Tax can play a role in regulating the amount of HMW complex present in the cell by decreasing the binding of 7SK snRNP/HEXIM1 to P-TEFb.	20926576	LncRNADisease
EL1120	RN7SK	Tat	RNA-Protein	binding	Tat efficiently replaces HEXIM1 on the 7SK snRNA in vivo and therefore, it promotes the disassembly of the 7SK/HEXIM/P-TEFb negative transcriptional regulatory snRNP to augment the nuclear level of active P-TEFb.	20976203	LncRNADisease
EL1120	RN7SK	HMGA1	RNA-Protein	binding	The 7SK-HMGA1 interaction not only adds an essential facet to the comprehension of transcriptional plasticity at the coupling of initiation and elongation, but also might provide a molecular link between HIV reprogramming of cellular gene expression-associated oncogenesis.	21087998	LncRNADisease
EL1120	RN7SK	CDK9	RNA-Protein	regulation	Stable expression of cdNIPP1 increased CDK9 phosphorylation on Thr(186) and the association of CDK9 with 7SK RNA. The stable expression of cdNIPP1 disrupted the interaction of Tat and PP1 and inhibited HIV-1 transcription. Expression of cdNIPP1 as a part of the HIV-1 genome inhibited HIV-1 replication.	21098020	LncRNADisease
EL1120	RN7SK	HMGA1	RNA-Protein	binding	7SK snRNA directly interacts through its loop2 (7SK L2) with the first A/T-hook DNA binding motif of HMGA1.	21282977	LncRNADisease
EL1120	RN7SK	P-TEFb	RNA-Protein	binding	TCR signaling led to the rapid dissociation of the large inactive P-TEFb:7SK RNP (small nuclear RNA 7SK ribonucleoprotein) complex and the release of active low-molecular-weight P-TEFb complexes.	21763495	LncRNADisease
EL1120	RN7SK	LARP7	RNA-Protein	regulation	The Lupus antigen (La)-related protein 7 (LARP7) is a constitutive component, the methylphosphate capping enzyme (MePCE) associates secondarily to phosphorylate the 5' end of 7SK snRNA.	21853533	LncRNADisease
EL1120	RN7SK	HMGA1	RNA-Protein	binding	We provide evidence for 7SK RNA complexes containing simultaneously HMGA1 and P-TEFb.	21957495	LncRNADisease
EL1120	RN7SK	P-TEFb	RNA-Protein	binding	We provide evidence for 7SK RNA complexes containing simultaneously HMGA1 and P-TEFb.	21957495	LncRNADisease
EL1120	RN7SK	Ars2	RNA-Protein	regulation	Ars2 contributes to histone mRNA 3'end formation and expression and these functional properties of Ars2 are negatively regulated by interaction with 7SK RNA.	22244333	LncRNADisease
EL1120	RN7SK	P-TEFb	RNA-Protein	regulation	The kinase activity of P-TEFb is reversibly inhibited by formation of a complex with the 334nt 7SK RNA, from which it is released under conditions of stress.	22303389	LncRNADisease
EL1120	RN7SK	P-TEFb	RNA-Protein	binding	Together with the HEXIM proteins, 7SK RNA associates with and sequesters a fraction of cellular P-TEFb into a catalytically inactive complex.	22377309	LncRNADisease
EL1120	RN7SK	P-TEFb	RNA-Protein	regulation	Regulation of P-TEFb by the d7SK snRNP is essential for the growth and differentiation of tissues required during Drosophila development.	22379134	LncRNADisease
EL1120	RN7SK	LARP7	RNA-Protein	binding	LARP7 negatively regulates positive transcription elongation factor-b (p-TEFb) by binding to and stabilizing 7sk RNA.	22488152	LncRNADisease
EL1120	RN7SK	ABO	RNA-RNA	regulation	Promoters pU6 and p7SK proved to express high levels of siRNA activity and can be used in the experiment of silencing alpha-1,3galactosyltransferase gene.	22522162	LncRNADisease
EL1120	RN7SK	HEXIM1	RNA-Protein	binding	The activity of P-TEFb is negatively regulated by an RNA-binding protein HEXIM1 in association with 7SK snRNA.	22609015	LncRNADisease