INTERACTION |
ID |
lncRNA Name |
Interaction target |
Level of interaction |
Type of interaction |
Description |
PMID |
Source |
EL1102 |
PVT1 |
c-Myc |
DNA-TF |
regulation |
PVT-1 regulates c-Myc gene transcription over a long distance. PVT-1 is also a downstream target of Myc proteins. |
17503467 |
LncRNADisease
|
EL1102 |
PVT1 |
c-Myc |
RNA-DNA |
regulation |
PVT-1 regulates c-Myc gene transcription over a long distance. PVT-1 is also a downstream target of Myc proteins. |
17503467 |
LncRNADisease
|
EL1102 |
PVT1 |
YY1 |
RNA-DNA |
regulation |
The risk allele (G) of rs378854 reduces binding of the transcription factor YY1 in vitro. The region surrounding rs378854 interacts with the MYC and PVT1 promoters.Expression of the PVT1 oncogene in normal prostate tissue increased with the presence of the risk allele of rs378854, while expression of MYC was not affected. |
21814516 |
LncRNADisease
|
EL1102 |
PVT1 |
P53 |
DNA-TF |
regulation |
The non-protein coding locus PVT1 is a p53-inducible target gene. |
22110125 |
LncRNADisease
|
EL1102 |
PVT1 |
serum α-fetoprotein |
RNA-Protein |
regulation |
overexpression of PVT1 was associated with a higher serum α-fetoprotein expression level (P=0.011) and a higher recurrence rate (P=0.004). |
25624916 |
|
EL1102 |
PVT1 |
EZH2 |
RNA-Protein |
binding |
we further confirmed that PVT1 was associated with enhancer of zeste homolog 2 (EZH2) and that this association was required for the repression of p15 and p16 |
25890171 |
|
EL1102 |
PVT1 |
EZH2 |
RNA-Protein |
regulation |
lncRNA PVT1 could be enriched by EZH2, and silencing PVT1 resulted in the decreased recruitment of EZH2. |
26427660 |
|
EL1102 |
PVT1 |
cyclin D1 and TSHR |
RNA-Protein |
regulation |
Silenced PVT1significantly decreased cyclin D1 and TSHR expressions. |
26427660 |
|
EL1102 |
PVT1 |
MYC |
DNA-DNA |
regulation |
Significantly lower MYC and PVT1 expression was observed during all-trans retinoic acid (ATRA)-induced differentiation and cell cycle arrest in the APL cell line. MYC knockdown in NB4 cells led to PVT1 downregulation. Moreover, PVT1 knockdown by RNA interference led to suppression of the MYC protein level, and cell proliferation was inhibited. |
26544536 |
|
EL1102 |
PVT1 |
LATS2 |
RNA-DNA |
regulation |
PVT1 recruits EZH2 to the large tumor suppressor kinase 2 (LATS2) promoter and represses LATS2 transcription. |
26908628 |
|
EL1102 |
PVT1 |
EZH2 |
RNA-Protein |
binding |
PVT1 recruits EZH2 to the large tumor suppressor kinase 2 (LATS2) promoter and represses LATS2 transcription. |
26908628 |
|
|