INTERACTION | |||||||||
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ID | lncRNA Name | Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||
EL1058 | PCGEM1 | miR-145 | RNA-RNA | regulation | Downregulation of PCGEM1 expression in LNCaP cells increased expression of miR-145, while overexpression of miR-145 decreased PCGEM1 expression. Transfection of the miR-145 expression vector and siRNA PCGEM1 inhibited tumor cell proliferation, migration, and invasion, and induced early apoptosis both in vitro. In contrast, there was no effect on RWPE-1 cells. | 25200485 | |||
EL1058 | PCGEM1 | miR-770 | RNA-RNA | binding | Target validation showed a direct binding between PCGEM1 and miR-770. PCGEM1 act as sponge lncRNA for miR-770 that regulates proliferation/apoptosis and autophagy, and suggest PCGEM1 as possible target for OA therapy. | 26340084 | |||