INTERACTION |
ID |
lncRNA Name |
Interaction target |
Level of interaction |
Type of interaction |
Description |
PMID |
Source |
EL1052 |
PCAT1 |
SUZ12 |
DNA-TF |
regulation |
Chromatin immunoprecipitation (ChIP) assays also demonstrated that SUZ12, a core PRC2 protein, directly binds the PCAT-1 promoter approximately 1kb upstream of the TSS. |
21804560 |
LncRNADisease
|
EL1052 |
PCAT1 |
EZH2 |
RNA-RNA |
co-expression |
Knockdown of EZH2 by shRNA or pharmacologic inhibition of EZH2 with the inhibitor 3-deazaneplanocin A (DZNep) caused a dramatic upregulation in PCAT-1 expression levels. |
21804560 |
LncRNADisease
|
EL1052 |
PCAT1 |
PRC2 |
RNA-Protein |
binding |
PCAT-1 is a prostate-specific regulator of cell proliferation and show that it is a target of the Polycomb Repressive Complex 2 (PRC2). Patterns of PCAT-1 and PRC2 expression stratified patient tissues into molecular subtypes distinguished by expression signatures of PCAT-1-repressed target genes. |
21804560 |
LncRNADisease
|
EL1052 |
PCAT1 |
cMyc |
RNA-DNA |
regulation |
The PCAT-1-cMyc relationship is mediated through the post-transcriptional activity of the MYC 3' untranslated region |
25425964 |
|
EL1052 |
PCAT1 |
p53 |
RNA-DNA |
regulation |
chromatin immunoprecipitation (ChIP) assays confirmed that PANDAR was a direct transcriptional target of p53 in NSCLC cells. |
25731728 |
|
|