INTERACTION |
ID |
lncRNA Name |
Interaction target |
Level of interaction |
Type of interaction |
Description |
PMID |
Source |
EL0973 |
NEAT1 |
PSP-1 |
RNA-Protein |
binding |
The PSP-1 RNA binding domain is required for its colocalization with NEAT1 RNA in paraspeckles, and biochemical analyses support that NEAT1 RNA binds with paraspeckle proteins. |
19217333 |
LncRNADisease
|
EL0973 |
NEAT1 |
DBHS |
RNA-Protein |
binding |
DBHS protein expression did not vary between the two cellular contexts, instead, paraspeckle induction and increased RNA nuclear retention correlated with the expression of the paraspeckle-specific structural ncRNA species NEAT1. |
19720872 |
LncRNADisease
|
EL0973 |
NEAT1 |
P54NRB/NONO |
RNA-Protein |
binding |
NEAT1 associates with DBHS proteins in vivo, as immunoprecipitation of PSF/SFPQ, P54NRB/NONO, and PSPC1 all copurify NEAT1 RNA to varying levels. |
19720872 |
LncRNADisease
|
EL0973 |
NEAT1 |
PSF/SFPQ |
RNA-Protein |
binding |
NEAT1 associates with DBHS proteins in vivo, as immunoprecipitation of PSF/SFPQ, P54NRB/NONO, and PSPC1 all copurify NEAT1 RNA to varying levels. |
19720872 |
LncRNADisease
|
EL0973 |
NEAT1 |
PSPC1 |
RNA-Protein |
binding |
NEAT1 associates with DBHS proteins in vivo, as immunoprecipitation of PSF/SFPQ, P54NRB/NONO, and PSPC1 all copurify NEAT1 RNA to varying levels. |
19720872 |
LncRNADisease
|
EL0973 |
NEAT1 |
P54nrb |
RNA-Protein |
binding |
a novel mechanism which is different from that reported |
20211624 |
|
EL0973 |
NEAT1 |
PSP1 |
RNA-Protein |
binding |
NEAT1 directly interacts with the paraspeckle protein PSP1. NEAT1 knockdown abolishes paraspeckles and relaxes the constraints on export of Alu-containing RNAs into the cytoplasm. |
20951849 |
LncRNADisease
|
EL0973 |
NEAT1 |
p54nrb |
RNA-Protein |
binding |
In the current model, NEAT1_2 interacts with core paraspeckle proteins PSF and p54nrb, which recruit PSP1 and NEAT1_1 and other associating molecules to the periphery of paraspeckles. |
21444682 |
LncRNADisease
|
EL0973 |
NEAT1 |
PSF |
RNA-Protein |
binding |
In the current model, NEAT1_2 interacts with core paraspeckle proteins PSF and p54nrb, which recruit PSP1 and NEAT1_1 and other associating molecules to the periphery of paraspeckles. |
21444682 |
LncRNADisease
|
EL0973 |
NEAT1 |
Proteins of the Drosophila behavior/human splicing |
RNA-Protein |
binding |
Additionally, mammalian DBHS proteins associate with the architectural long noncoding RNA NEAT1 to form paraspeckles, subnuclear bodies that alter gene expression via the nuclear retention of RNA. |
22416126 |
LncRNADisease
|
EL0973 |
NEAT1 |
miR-449a |
RNA-RNA |
regulation |
Further study of the interaction between miR-449a and NEAT1 show that NEAT1 was up-regulated when cells were transfected with miR-449a inhibitor, and NEAT1 was down-regulated when cells transfected with miR-449a mimics. |
25818739 |
|
EL0973 |
NEAT1 |
SWItch/Sucrose NonFermentable (SWI/SNF) chromatin-remodeling complexes |
RNA-Protein |
binding |
Subunits of SWItch/Sucrose NonFermentable (SWI/SNF) chromatin-remodeling complexes were identified as paraspeckle components that interact with PSPs and NEAT1 lncRNA. |
25831520 |
|
EL0973 |
NEAT1 |
p53 |
RNA-Protein |
regulation |
We used isogenic lymphoma cell line models to prove p53 dependence of NEAT1 and lincRNA-p21. The current work describes the p53-dependent miRNome and identifies lncRNAs NEAT1 and lincRNA-p21 as novel elements of the p53-dependent DNA damage response machinery in CLL and lymphoma. |
25971364 |
|
EL0973 |
NEAT1 |
MDTH, NM23 and MALAT1 |
DNA-DNA |
co-expression |
high NEAT1 expression levels were significantly associated with the expression level of MDTH, NM23 and MALAT1. |
26191242 |
|
EL0973 |
NEAT1 |
miR-140 |
DNA-RNA |
binding |
a miR-140 binding site in NEAT1 was identifiedand and mature miR-140 in the nucleus can physically interact with NEAT1, leading to increased NEAT1 expression. |
26457124 |
|
EL0973 |
NEAT1 |
miR-204/ZEB1 |
RNA-RNA |
regulation |
There was reciprocal repression between NEAT1 and miR-204. |
27020592 |
|
EL0973 |
NEAT1 |
ZEB1 |
RNA-Protein |
regulation |
ZEB1 was identified as a downstream target of miR-204 and NEAT1 upregulated ZEB1 expression by negatively regulating miR-204 expression. |
27020592 |
|
EL0973 |
NEAT1 |
HuR |
RNA-Protein |
binding |
NEAT1_1 was stabilized by an RNA-binding protein HuR, but suppressed by miR-124-3p in OC cells. |
27075229 |
|
EL0973 |
NEAT1 |
miR-124-3p |
RNA-RNA |
regulation |
NEAT1_1 was stabilized by an RNA-binding protein HuR, but suppressed by miR-124-3p in OC cells. |
27075229 |
|
EL0974 |
Neat1 |
Neat2 |
RNA-RNA |
co-expression |
Neat1 and Neat2 associate with nuclear paraspeckles and adjacent SC35 speckles, respectively;domains where transcription and co-transcriptional premRNA processing occur. |
20137068 |
LncRNADisease
|
EL0974 |
Neat1 |
SRp40 |
RNA-Protein |
binding |
SRp40 associated with NEAT1, as shown by RNA-IP on days 0 and 8, but decreased on day 4, and concentrations increased over that of IgG control. |
25437750 |
|
|