INTERACTION
ID	lncRNA Name	Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
EL0853	MALAT1	CREB	DNA-TF	regulation	We identified a shorter transcriptional initiation site and found that CREB binds to the defined proximal promoter of the MALAT1 gene. The expression of the tumor marker MALAT1 ncRNA is sensitive to cell surface receptor activation by oxytocin in a neuroblastoma cell line.	20149803	LncRNADisease
EL0853	MALAT1	SR	RNA-Protein	binding	MALAT1 interacts with SR proteins and influences the distribution of these and other splicing factors in nuclear speckle domains.	20797886	LncRNADisease
EL0853	MALAT1	SR proteins	RNA-Protein	binding	MALAT1 interacts with SR proteins and influences the distribution of these and other splicing factors in nuclear speckle domains.	20797886
EL0853	MALAT1	SR protein family	RNA-Protein	regulation	MALAT1 regulates the expression level, localization, and activity SR proteins.	20864030	LncRNADisease
EL0853	MALAT1	SRSF1	RNA-Protein	regulation	Upon MALAT1 depletion, expression of SRSF1 protein is increased.	20864030	LncRNADisease
EL0853	MALAT1	p54nrb	RNA-Protein	binding	In the current model， NEAT1_2 interacts with core paraspeckle proteins PSF and p54nrb, which recruit PSP1 and NEAT1_1 and other associating molecules to the periphery of paraspeckles.	21444682	LncRNADisease
EL0853	MALAT1	PSF	RNA-Protein	binding	In the current model， NEAT1_2 interacts with core paraspeckle proteins PSF and p54nrb, which recruit PSP1 and NEAT1_1 and other associating molecules to the periphery of paraspeckles.	21444682	LncRNADisease
EL0853	MALAT1	Pc2	DNA-Protein	regulation	methylation/demethylation of Polycomb 2 protein (Pc2) controls relocation of growth-control genes between Polycomb bodies (PcGs) and interchromatin granules (ICGs) in response to growth signals. This movement is the consequence of binding of methylated and unmethylated Pc2 to the ncRNAs TUG1 and MALAT1/NEAT2.	22078878	LncRNADisease
EL0853	MALAT1	Pc2	DNA-Protein	regulation	Methylation/demethylation of Polycomb 2 protein (Pc2) controls relocation of growth-control genes between Polycomb bodies (PcGs) and interchromatin granules (ICGs) in response to growth signals. This movement is the consequence of binding of methylated and unmethylated Pc2 to the ncRNAs TUG1 and MALAT1/NEAT2.	22078878	LncRNADisease
EL0853	MALAT1	RNPS1	RNA-Protein	regulation	RNAi-mediated repression of the nuclear speckle proteins, RNPS1, SRm160, or IBP160, which are well-known mRNA processing factors, resulted in the diffusion of MALAT-1 to the nucleoplasm.	22355166	LncRNADisease
EL0853	MALAT1	SRm160	RNA-Protein	regulation	RNAi-mediated repression of the nuclear speckle proteins, RNPS1, SRm160, or IBP160, which are well-known mRNA processing factors, resulted in the diffusion of MALAT-2 to the nucleoplasm.	22355166	LncRNADisease
EL0853	MALAT1	IBP160	RNA-Protein	regulation	RNAi-mediated repression of the nuclear speckle proteins, RNPS1, SRm160, or IBP160, which are well-known mRNA processing factors, resulted in the diffusion of MALAT-3 to the nucleoplasm.	22355166	LncRNADisease
EL0853	MALAT1	pre-mRNA splicing factors	RNA-Protein	regulation	MALAT1 interacts with pre-mRNA splicing factors and regulates cancer cell migration, synapse formation, cell cycle progression, and responses to serum stimulation.	23698766
EL0853	MALAT1	Bcl-2	RNA-DNA	regulation	An interaction of Bcl-2 with MALAT-1 lncRNA expression was revealed.	25036876
EL0853	MALAT1	Sp1 and LTBP3 promoter	RNA-DNA	binding	lncRNA MALAT1 directly interacted with Sp1 and LTBP3 promoterto increase expression of LTBP3 gene.	25187517
EL0853	MALAT1	Cisplatin and paclitaxel	N/A	regulation	Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs.	25257554
EL0853	MALAT1	SiRNA	RNA-RNA	regulation	SiRNA knockdown of HOTAIR in GC cells significantly inhibited cell proliferation	25280565
EL0853	MALAT1	PI3K/AKT signaling pathway	RNA-Protein	regulation	MALAT1 might suppress the tumor growth and metastasis via I3K/AKT signaling pathway.	25431257
EL0853	MALAT1	miR-101 and miR-217	RNA-RNA	regulation	A significant negative correlation exists between miR-101 or miR-217 and MALAT1 in 42 pairs of ESCC tissue samples and adjacent normal tissues.	25538231
EL0853	MALAT1	CCL5	RNA-Protein	regulation	The stimulation of colon cancer progression by TADC-derived CCL5 was associated with the up-regulation of non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), which subsequently increased the expression of Snail.	25546229
EL0853	MALAT1	ATM-CHK2 pathway	RNA-Protein	regulation	Western-blotting results implicated that the ATM-CHK2 pathway which is associated with G2/M arrest was phosphorylated by MALAT1 knockdown.	25613496
EL0853	MALAT1	RANKL	RNA-Protein	regulation	We found that RANKL induced the expression of a lncRNA, MALAT1, for the first time. Knockdown of RANK by siRNA blocked the induction of MALAT1 by RANKL. In addition, MALAT1 also regulated OPG expression in hFOB 1.19 cells.	25817340
EL0853	MALAT1	PI3K-AKT pathway	N/A	regulation	Downregulation of long noncoding RNA MALAT1 induces epithelial-to-mesenchymal transition via the PI3K-AKT pathway in breast cancer.	26191181
EL0853	MALAT1	miRNA-124	RNA-RNA	regulation	Knockdown of MALAT1 increased the expression of miRNA-124. MALAT1 can indirectly modulate GRB2 expression via competing miR-124.	26242259
EL0853	MALAT1	TDP-43	RNA-Protein	binding	TDP-43 directly bound to MALAT1 RNA. Silencing TDP-43 expression effectively decreased MALAT1 RNA transcript level. In contrast, TDP-43 overexpression markedly increased MALAT1 transcript level.	26265046
EL0853	MALAT1	hsa-miR-1	RNA-RNA	regulation	MiR-1 functioned as a tumor suppressor by targeting K-RAS and MALAT1.	26275461
EL0853	MALAT1	miR-145	RNA-RNA	regulation	miR-145 and MALAT1 were in the same Ago2 complex and there was a reciprocal repression between them.	26311052
EL0853	MALAT1	Sp1/3	DNA-Protein	regulation	Co-silencing of Sp1 and Sp3 synergistically repressed MALAT1 expression. Sp1 binding inhibitor, mithramycin A (MIT), also inhibited MALAT1 expression in HCC cells.	26352013
EL0853	MALAT1	EZH2 (enhancer of zeste homolog 2) and H3K27me3	RNA-Protein	regulation	Knockdown of MALAT1 reversed CSE-induced increases of EZH2 (enhancer of zeste homolog 2) and H3K27me3 levels. In addition to the alteration from epithelial to spindle-like mesenchymal morphology, chronic exposure of HBE cells to CSE increased the levels of EZH2, H3K27me3, vimentin, and N-cadherin and decreased E-cadherin levels, effects that were reversed by MALAT1 siRNA or EZH2 siRNA.	26415832
EL0853	MALAT1	miR-217	DNA-RNA	regulation	Over-expression of miR-217 with a mimic attenuated the CSE-induced increase of MALAT1 levels, and reduction of miR-217 levels by an inhibitor enhanced expression of MALAT1. MiR-217 regulation of EZH2/H3K27me3 via MALAT1 is involved in CSE-induced EMT and malignant transformation of HBE cells.	26415832
EL0853	MALAT1	miR-200s	RNA-RNA	binding	MALAT1 promote KIRC proliferation and metastasis through sponging miR-200s in vitro and in vivo.	26461224
EL0853	MALAT1	miR-1	RNA-RNA	regulation	There was reciprocal repression between MALAT1 and miR-1, and slug was identified as a downstream target of miR-1.	26482776
EL0853	MALAT1	EZH2	RNA-Protein	binding	EZH2 binds to MALAT1.The 3' end of MALAT1 interacts with the N-terminal of EZH2.	26516927
EL0853	MALAT1	N-cadherin, Vimentin, E-cadherin	RNA-Protein	regulation	MALAT1 knockdown significantly suppressed N-cadherin and Vimentin expression but induced E-cadherin expression in vitro.	26522444
EL0853	MALAT1	ZO-1, occludin and claudin-5	RNA-Protein	regulation	Knockdown of MALAT1 resulted in an impairment and increased the permeability of BTB as well as decreased the expression of ZO-1, occludin and claudin-5 in GECs.	26619802
EL0853	MALAT1	miR-140	RNA-RNA	regulation	There was reciprocal repression between MALAT1 and miR-140, and miR-140 mediated the effects that MALAT1 knockdown exerted.	26619802
EL0853	MALAT1	ERK/MAPK signaling	N/A	regulation	Downregulation of MALAT1 could activate ERK/MAPK signaling and promoted proliferation in SHG139 cells.	26649728
EL0853	MALAT1	Sox2 and Nestin	RNA-Protein	regulation	Downregulation of MALAT1 suppressed the expression of Sox2 and Nestin which are related to stemness.	26649728
EL0853	MALAT1	Hsa-miR-1	RNA-RNA	regulation	A reciprocal negative control relationship between MALAT1 and miR-1.	26676637
EL0853	MALAT1	pro-apoptotic proteins including cleaved caspase-3, cleaved caspase-9 and cleaved poly (ADP-ribose) polymerase-1 (PARP-1).	RNA-Protein	regulation	Reduced expression of MALAT-1 by RNA interference resulted in enhanced apoptosis in JEG-3 cells, accompanied with elevated levels of the pro-apoptotic proteins including cleaved caspase-3, cleaved caspase-9 and cleaved poly (ADP-ribose) polymerase-1 (PARP-1).	26722461
EL0853	MALAT1	PCDH10	RNA-DNA	regulation	Long noncoding RNA (lncRNA) MALAT1 binds EZH2, suppresses the tumor suppressor PCDH10, and promotes gastric cellular migration and invasion.	26871474
EL0853	MALAT1	EZH2	RNA-Protein	binding	Long noncoding RNA (lncRNA) MALAT1 binds EZH2, suppresses the tumor suppressor PCDH10, and promotes gastric cellular migration and invasion.	26871474
EL0853	MALAT1	miR-124	RNA-RNA	binding	MALAT1 acted as an endogenous potent regulator by directly binding to miR-124 and down-regulating miR-124 expression.	26918449
EL0853	MALAT1	cyclin-dependent kinase 4 (CDK4)	RNA-DNA	regulation	MALAT1 reversed the inhibitory effect of miR-124 on breast cancer proliferation and was involved in the cyclin-dependent kinase 4 (CDK4) expression.	26918449
EL0853	MALAT1	cdc42	RNA-DNA	regulation	MALAT1 regulated migration and invasion of breast cancer cells via affecting cdc42 through binding miR-1 competitively. miR-1 bound both MALAT1 and cdc42 3'UTR directly.	26926567
EL0853	MALAT1	miR-1	RNA-RNA	binding	MALAT1 regulated migration and invasion of breast cancer cells via affecting cdc42 through binding miR-1 competitively.	26926567