INTERACTION
ID	lncRNA Name	Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
EL0628	KCNQ1OT1	chromatin	RNA-DNA	binding	The bidirectional silencing property of Kcnq1ot1 maps to a highly conserved repeat motif within the silencing domain, which directs transcriptional silencing by interaction with chromatin, resulting in histone H3 lysine 9 trimethylation	18299392
EL0628	KCNQ1OT1	H3K9- and H3K27-specific histone methyltransferases G9a and the PRC2 complex	RNA-Protein	binding	Kcnq1ot1 interacts with chromatin and with the H3K9- and H3K27-specific histone methyltransferases G9a and the PRC2 complex in a lineage-specific manner. This interaction correlates with the presence of extended regions of chromatin enriched with H3K9me3 and H3K27me3 in the Kcnq1 domain in placenta, whereas fetal liver lacks both chromatin interactions and heterochromatin structures	18951091
EL0628	KCNQ1OT1	KvDMR1 and the Kcnq1	RNA-DNA	binding	The 5' region of Kcnq1ot1 RNA orchestrates a long-range intrachromosomal loop between KvDMR1 and the Kcnq1 promoter that is required for maintenance of imprinting.PRC2 (polycomb repressive complex 2), which participates in the allelic repression of Kcnq1, is also recruited by Kcnq1ot1 RNA via EZH2.	24395636
EL0628	KCNQ1OT1	SLC22A18, PHLDA2	RNA-DNA	regulation	Knockdown of β-catenin resulted in significant decrease of KCNQ1OT1 lncRNA-coated territory and an increase in the mRNA expression of the SLC22A18 and PHLDA2 genes that are regulated by KCNQ1OT1.	26868975
EL0628	KCNQ1OT1	β-catenin	DNA-Protein	binding	β-catenin can promote KCNQ1OT1 transcription through direct binding to the KCNQ1OT1 promoter.	26868975
EL0629	Kcnq1ot1	G9a	RNA-Protein	binding	Kcnq1ot1 interacts with chromatin and with the H3K9- and H3K27-specific histone methyltransferases G9a and the PRC2 complex in a lineage-specific manner.	18951091	LncRNADisease
EL0629	Kcnq1ot1	PRC2	RNA-Protein	binding	Kcnq1ot1 interacts with chromatin and with the H3K9- and H3K27-specific histone methyltransferases G9a and the PRC2 complex in a lineage-specific manner.	18951091	LncRNADisease
EL0629	Kcnq1ot1	H3K9me2 and H3K27me3	RNA-Protein	regulation	Gene silencing by the Kcnq1ot1 RNA involves repressive histone modifications, including H3K9me2 and H3K27me3, which are partly brought about by the G9a and Ezh2 histone methyltransferases.	19144718
EL0629	Kcnq1ot1	G9a	RNA-Protein	binding	The Kcnq1ot1 RNA also binds to the histone methyltransferase G9a.	19239885	LncRNADisease
EL0629	Kcnq1ot1	G9a	RNA-Protein	binding	The Kcnq1ot1 transcript that binds both G9a and PRC2.	19571010	LncRNADisease
EL0629	Kcnq1ot1	PRC2	RNA-Protein	binding	The Kcnq1ot1 transcript that binds both G9a and PRC2.	19571010	LncRNADisease
EL0629	Kcnq1ot1	PRC2	RNA-Protein	binding	PRC2 recruitment to the domain requires expression of the long ncRNA Kcnq1ot1.	19760321	LncRNADisease
EL0629	Kcnq1ot1	Dnmt1	RNA-Protein	binding	Kcnq1ot1 mediates transcriptional gene silencing by interacting with Dnmt1. Kcnq1ot1 recruits Dnmt1 to somatic DMRs by interacting with Dnmt1.	20573698	LncRNADisease
EL0629	Kcnq1ot1	Dnmt1	RNA-DNA	binding	Kcnq1ot1 recruits Dnmt1 to somatic DMRs by interacting with Dnmt1	20573698
EL0629	Kcnq1ot1	Kcnq1	RNA-DNA	regulation	Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1.	21256239	LncRNADisease
EL0629	Kcnq1ot1	Kcnq1	RNA-DNA	regulation	Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1.	21256239	LncRNADisease
EL0629	Kcnq1ot1	Dnmt1	RNA-Protein	binding	Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1.	21256239	LncRNADisease
EL0629	Kcnq1ot1	Dnmt1	RNA-Protein	binding	Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1.	21256239	LncRNADisease
EL0629	Kcnq1ot1	G9a	RNA-Protein	binding	Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1.	21256239	LncRNADisease
EL0629	Kcnq1ot1	G9a	RNA-Protein	binding	Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1.	21256239	LncRNADisease
EL0629	Kcnq1ot1	PRC1	RNA-Protein	binding	Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1.	21256239	LncRNADisease
EL0629	Kcnq1ot1	PRC1	RNA-Protein	binding	Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1.	21256239	LncRNADisease
EL0629	Kcnq1ot1	PRC2	RNA-Protein	binding	Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1.	21256239	LncRNADisease
EL0629	Kcnq1ot1	PRC2	RNA-Protein	binding	Epigenetically silences the Kcnq1 imprinting control region by recruiting repressive chromatin remodelling complexes such as G9a, PRC1 and PRC2, and the DNA methylase Dnmt1.	21256239	LncRNADisease
EL0629	Kcnq1ot1	G9a	RNA-Protein	binding	Kcnq1ot1 interacts with the histone methyltransferases G9a and PRC2, effectively forming a repression domain in cis to its transcription site through recruitment of polycomb complexes.	21925379	LncRNADisease
EL0629	Kcnq1ot1	PRC2	RNA-Protein	binding	Kcnq1ot1 interacts with the histone methyltransferases G9a and PRC2, effectively forming a repression domain in cis to its transcription site through recruitment of polycomb complexes.	21925379	LncRNADisease
EL0629	Kcnq1ot1	EZH2	RNA-Protein	binding	HOTAIR, Kcnq1ot and Xist all mediate their effects by interacting with the Polycomb-repressive complex 2 (PRC2) component Ezh2 (enhancer of zeste homolog 2 (Drosophila)) and modulating histone methylation.	21936910	LncRNADisease
EL0629	Kcnq1ot1	Kcnq	DNA-DNA	regulation	Kcnq1ot is important for silencing of the Kcnq locus resulting from parental imprinting.	21936910	LncRNADisease