INTERACTION
ID	lncRNA Name	Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
EL0600	HULC	miR-372	RNA-RNA	binding	Acts as a sponge/target mimic for miR-372 reducing its expression and activity.	21256239	LncRNADisease
EL0600	HULC	miR-372	RNA-DNA	regulation	highly upregulated in liver cancer (HULC) lncRNA sequesters endogenous miR-372 to modulate its own transcriptional upregulation in HCC.	21802130	LncRNADisease
EL0600	HULC	CLOCK	RNA-Protein	regulation	Our observations showed that HULC was able to heighten the expression levels of CLOCK and its downstream circadian oscillators	25622901
EL0600	HULC	p18	RNA-Protein	regulation	RIP assay showed that HULC down-regulated the level of p18 directly.	25952928
EL0600	HULC	E2F1	RNA-TF	regulation	HULC activated the promoter of SPHK1 in hepatoma cells through the transcription factor E2F1. E2F1 was capable of binding to the E2F1 element in the SPHK1 promoter. HULC increased the expression of E2F1 in hepatoma cells and levels of HULC were positively correlated with those of E2F1 in HCC tissues.	26540633
EL0600	HULC	SPHK1	RNA-Protein	regulation	HULC increased SPHK1 in hepatoma cells.	26540633
EL0600	HULC	miR-107	RNA-RNA	regulation	HULC sequestered miR-107, which targeted E2F1 mRNA 3'UTR, by complementary base pairing.	26540633
EL0600	HULC	TNF-α	RNA-Protein	regulation	HULC expression was decreased with TNF-α treatment. Restoring HULC expression rescued the apoptosis induced by TNF-α.	26981838
EL0600	HULC	miR-9	RNA-RNA	regulation	HULC modulated miR-9 expression through association with DNA methyltransferases and suppression of miR-9 expression.	26981838