INTERACTION
ID	lncRNA Name	Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
EL0582	HOTTIP	HOXA	RNA-Protein	binding	HOTTIP RNA binds the adaptor protein WDR5 directly and targets WDR5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription.	21423168	LncRNADisease
EL0582	HOTTIP	HOXA	RNA-Protein	binding	HOTTIP RNA binds the adaptor protein WDR5 directly and targets WDR5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription.	21423168	LncRNADisease
EL0582	HOTTIP	WDR5	RNA-Protein	binding	HOTTIP RNA binds the adaptor protein WDR5 directly and targets WDR5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription.	21423168	LncRNADisease
EL0582	HOTTIP	WDR5	RNA-Protein	binding	HOTTIP RNA binds the adaptor protein WDR5 directly and targets WDR5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription.	21423168	LncRNADisease
EL0582	HOTTIP	HOXA	RNA-DNA	regulation	Recently, another trans-acting lincRNA, called HOTTIP, has been described activating the transcription of several HOXA genes in vivo by recruiting the proteins Mll1 and Wdr5 on the transcription start sites of the 5' HOXA genes.	21423168	LncRNADisease
EL0582	HOTTIP	HOXA	RNA-DNA	regulation	Recently, another trans-acting lincRNA, called HOTTIP, has been described activating the transcription of several HOXA genes in vivo by recruiting the proteins Mll1 and Wdr5 on the transcription start sites of the 5' HOXA genes.	21423168	LncRNADisease
EL0582	HOTTIP	Mll1	RNA-Protein	binding	Recently, another trans-acting lincRNA, called HOTTIP, has been described activating the transcription of several HOXA genes in vivo by recruiting the proteins Mll1 and Wdr5 on the transcription start sites of the 5' HOXA genes.	21423168	LncRNADisease
EL0582	HOTTIP	Mll1	RNA-Protein	binding	Recently, another trans-acting lincRNA, called HOTTIP, has been described activating the transcription of several HOXA genes in vivo by recruiting the proteins Mll1 and Wdr5 on the transcription start sites of the 5' HOXA genes.	21423168	LncRNADisease
EL0582	HOTTIP	Wdr5	RNA-Protein	binding	Recently, another trans-acting lincRNA, called HOTTIP, has been described activating the transcription of several HOXA genes in vivo by recruiting the proteins Mll1 and Wdr5 on the transcription start sites of the 5' HOXA genes.	21423168	LncRNADisease
EL0582	HOTTIP	Wdr5	RNA-Protein	binding	Recently, another trans-acting lincRNA, called HOTTIP, has been described activating the transcription of several HOXA genes in vivo by recruiting the proteins Mll1 and Wdr5 on the transcription start sites of the 5' HOXA genes.	21423168	LncRNADisease
EL0582	HOTTIP	WDR5	RNA-Protein	binding	HOTTIP RNA binds the adaptor protein WDR5 directly and targets WDR5/MLL complexes across HOXA, driving histone H3 lysine 4 trimethylation and gene transcription.	21423168
EL0582	HOTTIP	WDR5	RNA-Protein	binding	HOTTIP was shown to mediate enhancerlike effects on the adjacent genes through a mechanism involving direct interaction with the adaptor protein WDR5.	21831473	LncRNADisease
EL0582	HOTTIP	HOXA	DNA-DNA	regulation	This study identified HOTTIP in association with the promoter regions of downstream 5'HOXA genes.	21831473	LncRNADisease
EL0582	HOTTIP	HOXA	RNA-RNA	co-expression	Knockdown of HOTTIP in foreskin fibroblasts resulted in lower 5’HOXA gene expression.	21874119	LncRNADisease
EL0582	HOTTIP	WDR5	RNA-Protein	binding	HOTTIP and Mistral recruit chromatin-activating complexes (WDR5/MLL1) in cis to neighboring genes.	22190456	LncRNADisease
EL0582	HOTTIP	FLJ21870	RNA-RNA	co-expression	Half-sbsRNA1 siRNA increased the levels of SERPINE1 and FLJ21870 mRNAs to 2-to-4.5-fold above normal.	23728290
EL0582	HOTTIP	HOXA gene cluster,miR-125b	RNA-DNA, RNA-RNA	regulation	Knock-down of HOTTIP significantly suppressed the expression of a number of HOXA genes. Furthermore, we identified miR-125b as a post-transcriptional regulator of HOTTIP.	25424744
EL0582	HOTTIP	HOXA13	RNA-Protein	regulation	Knockdown of HOXA13 by RNA interference (siHOXA13) revealed that HOTTIP promoted PDAC cell proliferation, invasion, and chemoresistance, at least partly through regulating HOXA13.	25889214
EL0582	HOTTIP	HOX gene	RNA-DNA	regulation	HOTTIP does not regulate HOXA13 but plays a role in regulation of several other HOX genes includingHOXA10, HOXB2, HOXA11, HOXA9 and HOXA1.	25912306
EL0582	HOTTIP	HOXA13	RNA-Protein	co-expression	LncRNA HOTTIP and HOXA13 were significantly down-regulated in HSCR compared to the controls. SiRNA-mediated knock-down of HOTTIP or HOXA13 correlated with decreased levels of each other and both reduced the cell migration and proliferation without affecting cell apoptosis or cell cycle.	26043692
EL0582	HOTTIP	p21	RNA-Protein	regulation	HOTTIP potentially contributed to CRC cell growth partially through the silencing of p21 expression.	26678886
EL0582	HOTTIP	miR-192 and miR-204	DNA-RNA	regulation	miR-192 and miR-204 as two microRNAs (miRNAs) suppressing HOTTIP expression via the Argonaute 2 (AGO2)-mediated RNA interference (RNAi) pathway in HCC. The posttranscriptional silencing of HOTTIP by miR-192, miR-204 or HOTTIP siRNAs could significantly suppress viability of HCC cells. The miR-192/-204-HOTTIP axis may interrupt HCC glutaminolysis through GLS1 inhibition. Besides the known targets (multiple 5' end HOX A genes, i.e. HOXA13), glutaminase (GLS1) was identified as a potential downstream target of the miR-192/-204-HOTTIP axis in HCC.	26710269