INTERACTION
ID	lncRNA Name	Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
EL0578	HOTAIR	HOXD	RNA-DNA	regulation	HOTAIR is transcribed at the intersection of opposing chromatin domains in the HOXC locus, but targets Polycomb Repressive Complex 2 (PRC2) to represses transcription in trans across 40 kilobases of the HOXD locus.	17604720	LncRNADisease
EL0578	HOTAIR	PRC2	RNA-Protein	binding	HOTAIR is transcribed at the intersection of opposing chromatin domains in the HOXC locus, but targets Polycomb Repressive Complex 2 (PRC2) to silence 40 kilobases of HOXD.	17604720	LncRNADisease
EL0578	HOTAIR	HOXD	RNA-DNA	regulation	HOTAIR represses transcription in trans across 40 kilobases of the HOXD locus.	17604720	LncRNADisease
EL0578	HOTAIR	HOXD locus,Polycomb Repressive Complex 2 (PRC2)	RNA-Protein	regulation	HOTAIR, which represses transcription in trans across 40 kilobases of the HOXD locus. HOTAIR interacts with Polycomb Repressive Complex 2 (PRC2) and is required for PRC2 occupancy and histone H3 lysine-27 trimethylation of HOXD locus.	17604720
EL0578	HOTAIR	HOXD	RNA-DNA	regulation	HOTAIR represses the expression in trans of genes in the HOXD cluster. Depletion of HOTAIR by siRNA resulted in the activation of HOXD genes in trans.	19015002	LncRNADisease
EL0578	HOTAIR	Ezh2	RNA-Protein	binding	HOTAIR RNA plays a critical role in establishing H3K27me3 enriched chromosomal domains through interaction with PRC2 complex members such as Suz12 and Ezh2.	19015002	LncRNADisease
EL0578	HOTAIR	Suz12	RNA-Protein	binding	HOTAIR RNA plays a critical role in establishing H3K27me3 enriched chromosomal domains through interaction with PRC2 complex members such as Suz12 and Ezh2.	19015002	LncRNADisease
EL0578	HOTAIR	HOXD	RNA-RNA	co-expression	HOTAIR showed negative association with HOXD genes.	19182780	LncRNADisease
EL0578	HOTAIR	PRC2	RNA-Protein	binding	HOTAIR coprecipitated with PRC2 in both HeLa and hFFs, but not in hLFs.	19571010	LncRNADisease
EL0578	HOTAIR	PRC2	RNA-Protein	binding	HOTAIR expression may be involved in human cancer by promoting genomic relocalization of Polycomb complex and H3K27 trimethylation.	20393566	LncRNADisease
EL0578	HOTAIR	H3	RNA-Protein	regulation	HOTAIR expression may be involved in human cancer by promoting genomic relocalization of Polycomb complex and H3K27 trimethylation.	20393566	LncRNADisease
EL0578	HOTAIR	H3	RNA-Protein	regulation	HOTAIR expression may be involved in human cancer by promoting genomic relocalization of Polycomb complex and H3K27 trimethylation.	20393566	LncRNADisease
EL0578	HOTAIR	LSD1	RNA-Protein	binding	A 3' domain of HOTAIR binds the LSD1/CoREST/REST complex.	20616235	LncRNADisease
EL0578	HOTAIR	PRC2	RNA-Protein	binding	A 5'domain of HOTAIR binds polycomb repressive complex 2 (PRC2).	20616235	LncRNADisease
EL0578	HOTAIR	LSD1	RNA-Protein	binding	Immunoprecipitation (IP) of LSD1 retrieved endogenous HOTAIR with comparable enrichment to that of PRC2 IP. It was hypothesized that HOTAIR may also bind the LSD1-CoREST complex.	20616235	LncRNADisease
EL0578	HOTAIR	HOXD	RNA-DNA	regulation	The lincRNA HOTAIR is transcribed from the HOXC locus and targets Polycomb Repressive Complex 2 (PRC2, comprised of H3K27 methylase EZH2, SUZ12, and EED) to silence HOXD and select genes on other chromosomes.	20616235	LncRNADisease
EL0578	HOTAIR	PRC2	RNA-Protein	binding	The lincRNA HOTAIR is transcribed from the HOXC locus and targets Polycomb Repressive Complex 2 (PRC2, comprised of H3K27 methylase EZH2, SUZ12, and EED) to silence HOXD and select genes on other chromosomes.	20616235	LncRNADisease
EL0578	HOTAIR	PRC2	RNA-DNA	regulation	binding surface assemble select histone modification enzymes thereby specifying the pattern of histone modifications on target genes	20616235
EL0578	HOTAIR	HOXD	RNA-Protein	regulation	The lncRNA HOTAIR is a putative direct positive regulator of the Polycomb repressor complex, and is consequently an indirect negative regulator of homeobox-D transcription factors.	20951849	LncRNADisease
EL0578	HOTAIR	PRC2	RNA-Protein	regulation	The lncRNA HOTAIR is a putative direct positive regulator of the Polycomb repressor complex.	20951849	LncRNADisease
EL0578	HOTAIR	Ezh2	RNA-Protein	binding	Ezh2 interacts with HOTAIR and Xist.	21123648	LncRNADisease
EL0578	HOTAIR	CoREST	RNA-Protein	binding	Epigenetically silences gene expression at many loci by recruitment of LSD1/CoREST/REST and PRC2 repressive chromatin modifying complexes. Oncogene: promotes tumour metastasis.	21256239	LncRNADisease
EL0578	HOTAIR	LSD1	RNA-Protein	binding	Epigenetically silences gene expression at many loci by recruitment of LSD1/CoREST/REST and PRC2 repressive chromatin modifying complexes. Oncogene: promotes tumour metastasis.	21256239	LncRNADisease
EL0578	HOTAIR	PRC2	RNA-Protein	binding	Epigenetically silences gene expression at many loci by recruitment of LSD1/CoREST/REST and PRC2 repressive chromatin modifying complexes. Oncogene: promotes tumour metastasis.	21256239	LncRNADisease
EL0578	HOTAIR	REST	RNA-Protein	binding	Epigenetically silences gene expression at many loci by recruitment of LSD1/CoREST/REST and PRC2 repressive chromatin modifying complexes. Oncogene: promotes tumour metastasis.	21256239	LncRNADisease
EL0578	HOTAIR	PRC2	RNA-Protein	binding	CDK1 and CDK2 phosphorylate EZH2 at threonine 350 (T350) and that T350 phosphorylation is important for the binding of EZH2 to PRC2 recruiters, such as noncoding RNAs (ncRNAs) HOTAIR and XIST.	21278485	LncRNADisease
EL0578	HOTAIR	LSD1	RNA-Protein	binding	Analysis of HOTAIR revealed that a 5' end domain binds PRC2 and a 3' end domain binds an LSD1 (H3K4me2 demethylase) containing complex.	21496640	LncRNADisease
EL0578	HOTAIR	PRC2	RNA-Protein	binding	Analysis of HOTAIR revealed that a 5' end domain binds PRC2 and a 3' end domain binds an LSD1 (H3K4me2 demethylase) containing complex.	21496640	LncRNADisease
EL0578	HOTAIR	HOXD	RNA-DNA	regulation	HOTAIR, a paradigm of this new class of RNAs, is localized within the human HOXC gene cluster and was shown,in human cells, to regulate HOXD genes in trans via the recruitment of Polycomb Repressive Complex 2 (PRC2), followed by the trimethylation of lysine 27 of histone H3.	21637793	LncRNADisease
EL0578	HOTAIR	PRC2	RNA-Protein	binding	HOTAIR, a paradigm of this new class of RNAs, is localized within the human HOXC gene cluster and was shown,in human cells, to regulate HOXD genes in trans via the recruitment of Polycomb Repressive Complex 2 (PRC2), followed by the trimethylation of lysine 27 of histone H3.	21637793	LncRNADisease
EL0578	HOTAIR	PRC2	RNA-Protein	binding	HOTAIR, a paradigm of this new class of RNAs, is localized within the human HOXC gene cluster and was shown,in human cells, to regulate HOXD genes in trans via the recruitment of Polycomb Repressive Complex 2 (PRC2), followed by the trimethylation of lysine 27 of histone H3.	21637793	LncRNADisease
EL0578	HOTAIR	H3	RNA-Protein	regulation	HOTAIR, a paradigm of this new class of RNAs, is localized within the human HOXC gene cluster and was shown,in human cells, to regulate HOXD genes in trans via the recruitment of Polycomb Repressive Complex 2 (PRC2), followed by the trimethylation of lysine 27 of histone H3.	21637793	LncRNADisease
EL0578	HOTAIR	Hox	RNA-DNA	regulation	HOTAIR is transcribed from within specific Hox gene clusters but regulates the expression of Hox genes located on different chromosomes.	21936910	LncRNADisease
EL0578	HOTAIR	EZH2	RNA-Protein	binding	HOTAIR, Kcnq1ot and Xist all mediate their effects by interacting with the Polycomb-repressive complex 2 (PRC2) component Ezh2 (enhancer of zeste homolog 2 (Drosophila)) and modulating histone methylation.	21936910	LncRNADisease
EL0578	HOTAIR	β-catenin	RNA-Protein	regulation	β-catenin is a stretch responsive signaling pathway that represses HOTAIR	24788418
EL0578	HOTAIR	PPARγ and LPL	RNA-DNA	regulation	Ectopic expression of HOTAIR in abdominal preadipocytes produced an increase in differentiation as reflected by a higher percentage of differentiated cells, and increased expression of key adipogenic genes including PPARγ and LPL	24862299
EL0578	HOTAIR	Wnt inhibitory factor 1	RNA-Protein	regulation	A significant inverse correlation between HOTAIR and WIF-1 expression was demonstrated in Ta/T1 BC tissues.	25030736
EL0578	HOTAIR	Cisplatin and paclitaxel	N/A	regulation	Cisplatin and paclitaxel have target function on significant lncRNAs in LSCC, which presents novel molecular targets to cure LSCC patients and also leads an orientation for developing new drugs.	25257554
EL0578	HOTAIR	SiRNA	RNA-RNA	regulation	SiRNA knockdown of HOTAIR in GC cells significantly inhibited cell proliferation	25280565
EL0578	HOTAIR	histone H3 lysine27	RNA-Protein	binding	MCF-7-TNR cells exhibited reduced suppressive histone H3 lysine27 trimethylation on the HOTAIR promoter.	25328122
EL0578	HOTAIR	endothelial growth factor, matrix metalloproteinase-9 and epithelial-to-mesenchymal transition (EMT)-related genes	RNA-DNA	regulation	HOTAIR regulated the expression of vascular endothelial growth factor, matrix metalloproteinase-9 and epithelial-to-mesenchymal transition (EMT)-related genes	25405331
EL0578	HOTAIR	protein coding gene	RNA-DNA	regulation	GO analyses of most significantly correlated coding genes of HOTAIR and lncRNA-422 showed that these two lncRNAs may participate in carcinogenesis by regulating protein coding genes involved in special biological process relevant to cancer.	25456707
EL0578	HOTAIR	p21	RNA-DNA	regulation	Knockdown of HOTAIR upregulated p21.	25547435
EL0578	HOTAIR	shHOTAIR	RNA-RNA	regulation	Our findings demonstrated the shHOTAIR-mediated down-regulation of the HOTAIR expression in CD117(+)CD44(+) CSCs can be a promising new opportunity for future clinical trials.	25792974
EL0578	HOTAIR	β-catenin	DNA-Protein	regulation	We show that expression of HOTAIR is regulated by β-catenin through a LEF1/TCF4-binding site. The dual treatment blocks nuclear expression of β-catenin and prevents its recruitment to the HOTAIR promoter.	25883211
EL0578	HOTAIR	c-KIT,miR-193a	RNA-DNA	binding	HOTAIR modulated c-KIT expression by competitively binding miR-193a.	25979172
EL0578	HOTAIR	miR-218	RNA-RNA	regulation	Hotair negatively regulated miR-218 expression in HCC, which might be mediated through an EZH2-targeting-miR-218-2 promoter regulatory axis.	26024833
EL0578	HOTAIR	HIF-1α	DNA-Protein	binding	The function of the hypoxia-inducible factor-1α (HIF-1α) binding site to hypoxia-responsive elements (HREs) in the HOTAIR promoter region. HOTAIR is a direct target of HIF-1α through interaction with putative HREs in the upstream region of HOTAIR in NSCLC cells.	26088446
EL0578	HOTAIR	E7	RNA-Protein	co-expression	Expression of HOTAIR and PRC2-complex members (EZH2 and SUZ12), showed significant positive correlation with E7 expression in CaCx cases and E7 transfected C33A cell line, suggestive of interplay between E7 and HOTAIR.	26152361
EL0578	HOTAIR	SETD2	RNA-DNA	regulation	HOTAIR promotes tumorigenesis via downregulating SETD2 in liver cancer stem cells.	26172293
EL0578	HOTAIR	miR-326	RNA-RNA	regulation	HOTAIR was confirmed to be the target of miR-326 . knock-down of HOTAIR up-regulated miR-326 expression.	26183397
EL0578	HOTAIR	miR-152	RNA-RNA	regulation	Long non-coding RNA HOTAIR promotes HLA-G expression via inhibiting miR-152 in gastric cancer cells.	26187665
EL0578	HOTAIR	CaV1.2	RNA-Protein	regulation	In the present study, we demonstrated that up-regulation of HOTAIR could suppress the expression of CaV1.2 in human cardiomyocytes.	26255135
EL0578	HOTAIR	Wnt/β-catenin pathway	N/A	regulation	HOTAIR promotes the initiation and chemoresistance of ovarian cancer by activating wnt/β-catenin signaling.	26341496
EL0578	HOTAIR	ER	RNA-Protein	regulation	The long non-coding RNA HOTAIR is directly repressed by ER and its upregulation promotes ligand-independent ER activities and contributes to tamoxifen resistance.	26364613
EL0578	HOTAIR	AR	RNA-Protein	binding	HOTAIR binds to the AR protein to block its interaction with the E3 ubiquitin ligase MDM2, thereby preventing AR ubiquitination and protein degradation.	26411689
EL0578	HOTAIR	EZH2	RNA-Protein	regulation	A significant correlation between EZH2 and HOTAIR expression levels. EZH2 regulates HOTAIR expression.	26457124
EL0578	HOTAIR	microRNA-205	RNA-RNA	regulation	A long non-coding RNA HOTAIR (HOX transcript antisense RNA) was observed to participate in the silencing of miR-205 in bladder cancer cells by breaking the balance of histone modification between H3K4me3 (histone H3 at lysine 4 methylation) and H3K27me3 on miR-205 promoter.	26469956
EL0578	HOTAIR	cell death pathway	N/A	regulation	Protein expression analysis indicated that mitochondrial related cell death pathway (Bcl-2, BAX, Caspase-3, Cleaved Caspase-3, Cytochrome c) involved in HOTAIR dependent apoptosis process.	26592246
EL0578	HOTAIR	LSH	RNA-Protein	regulation	HOTAIR is associated with LSH, and this association linked with the binding of LSH in the promoter of FOXA1, not FOXA2.	26658322
EL0578	HOTAIR	FOXA1, FOXA2	RNA-Protein	regulation	HOTAIR regulates the ratio of FOXA1 to FOXA2 and migration and invasion.	26658322
EL0578	HOTAIR	VEGFA and Ang2	RNA-Protein	regulation	Hotair promoted angiogenesis through directly activating the transcription of angiogenic factor VEGFA as well as through GRP78-mediated upregulation of VEGFA and Ang2 expression.	26717040
EL0578	HOTAIR	c-Myc	RNA-DNA	binding	HBXIP interacted directly with c-Myc through the leucine zippers and recruited the lncRNA Hotair along with the histone demethylase LSD1, for which Hotair serves as a scaffold.	26719542
EL0578	HOTAIR	epithelial-to-mesenchyme transition (EMT) genes	RNA-DNA	regulation	Loss of HOTAIR expression in UBC cell lines alters expression of epithelial-to-mesenchyme transition (EMT) genes including SNAI1, TWIST1, ZEB1, ZO1, MMP1 LAMB3, and LAMC2.	26800519
EL0578	HOTAIR	TNF-α, NF-κB	RNA-Protein	regulation	HOTAIR upregulation in cardiomyocytes of LPS-induced sepsis mice promoted TNF-α production in the circulation by activating NF-κB, involving the phosphorylation of NF-κB p65 subunit.	26806307
EL0578	HOTAIR	miR-125a-5p	RNA-RNA	regulation	microRNA miR-125a-5p decreases and releases caspase 2 to promote cancer cell apoptosis after HOTAIR knockdown.	26962687
EL0579	Hotair	HOXD genes	RNA-DNA	regulation	We show that the cognate mouse Hotair is poorly conserved in sequence; and its absence, along with the deletion of the HoxC cluster, has surprisingly little effect in vivo, neither on the expression pattern or transcription efficiency, nor on the amount of K27me3 coverage of different Hoxd target genes.	21637793
EL0579	Hotair	Polycomb repressive complex 2 and Lsd1 complex	RNA-Protein	binding	Hotair binds to both Polycomb repressive complex 2, which methylates histone H3 at lysine 27 (H3K27), and Lsd1 complex, which demethylates histone H3 at lysine 4 (H3K4) in vivo. Hotair inactivation causes H3K4me3 gain and, to a lesser extent, H3K27me3 loss at target genes.	24075995
EL0579	Hotair	HoxD	RNA-DNA	regulation	RNA sequencing and conditional inactivation reveal an ongoing requirement of Hotair to repress HoxD genes and several imprinted loci such as Dlk1-Meg3 and Igf2-H19 without affecting imprinting choice.	24075995