INTERACTION |
ID |
lncRNA Name |
Interaction target |
Level of interaction |
Type of interaction |
Description |
PMID |
Source |
EL0555 |
H19 |
Igf2 of imprinted gene network (IGN) |
RNA-Protein |
regulation |
We observed postnatal growth reduction in two independent transgenic lines and detected a decrease of Igf2 expression in embryos. An extensive analysis of several other genes from the newly described imprinted gene network (IGN) was performed in both loss- and gain-of-function animals. We found that H19 deletion leads to the upregulation of several genes of the IGN. |
19762426 |
|
EL0555 |
H19 |
let-7 |
RNA-RNA |
binding |
Acting as a molecular sponge, H19 inhibits microRNA (miRNA) let-7. |
25399420 |
|
EL0555 |
H19 |
Igf2 (insulin-like growth factor 2) |
RNA-DNA |
regulation |
This is associated with the disruption of igf2 imprinting and the consequent biallelic expression of this gene. |
9203585 |
|
EL0556 |
H19 |
SERPINE1 |
RNA-RNA |
co-expression |
Half-sbsRNA1 siRNA increased the levels of SERPINE1 and FLJ21870 mRNAs to 2-to-4.5-fold above normal. |
10738131 |
|
EL0556 |
H19 |
IMP |
RNA-Protein |
binding |
Human h19 rna contains four attachment sites for the oncofetal igf-ii mrna-binding protein (imp) |
10875929 |
|
EL0556 |
H19 |
IMP-3 |
RNA-Protein |
regulation |
Imp-3 protein associates with igf-ii leader-3 and leader-4 mrnas and h19 rna |
15753088 |
|
EL0556 |
H19 |
miR-675 |
RNA-RNA |
co-expression |
Recently, it was found that the H19 RNA is host to an exonic microRNA, miR-675, which, as a result, is also imprinted and maternally expressed. |
19239885 |
LncRNADisease
|
EL0556 |
H19 |
c-myc |
DNA-TF |
regulation |
H19 has been linked to the oncogene, c-myc, which positively regulates its expression in diverse cell types including T98G human glioblastoma cells. |
20380817 |
LncRNADisease
|
EL0556 |
H19 |
p53 |
DNA-TF |
regulation |
H19 has been linked to the tumor suppressor, p53, which negatively regulates its expression. |
20380817 |
LncRNADisease
|
EL0556 |
H19 |
GLI1 |
DNA-TF |
regulation |
H19 is a target of the GLI1 transcription factor, which mediates SHH signaling and is amplified more than 50-fold in human gliomas. |
20380817 |
LncRNADisease
|
EL0556 |
H19 |
SHH |
DNA-TF |
regulation |
H19 is a target of the GLI1 transcription factor, which mediates SHH signaling and is amplified more than 50-fold in human gliomas. |
20380817 |
LncRNADisease
|
EL0556 |
H19 |
E2F1 |
RNA-Protein |
regulation |
H19 transcription is positively regulated by the cell cycle regulatory factor, E2F1, during the S-phase of growth-stimulated cells. |
20380817 |
LncRNADisease
|
EL0556 |
H19 |
Igf2 |
RNA-RNA |
co-expression |
Complex functions, influences growth by down-regulating a number of imprinted genes including Igf2, also implicated as both a tumour suppressor and an oncogene. |
21256239 |
LncRNADisease
|
EL0556 |
H19 |
CTCF1 |
RNA-RNA |
co-expression |
Significant reductions at the H19 CTCF 1 and CTCF 2 binding sites were observed in the offspring of ethanol-treated sires, which was significantly correlated with reduced weight at postnatal days 35-42 (p?0.05). |
22395465 |
LncRNADisease
|
EL0556 |
H19 |
CTCF2 |
RNA-RNA |
co-expression |
Significant reductions at the H19 CTCF 1 and CTCF 2 binding sites were observed in the offspring of ethanol-treated sires, which was significantly correlated with reduced weight at postnatal days 35-42 (p<=0.05). |
22395465 |
LncRNADisease
|
EL0556 |
H19 |
CTCF3 |
RNA-RNA |
co-expression |
There is a CTCF-binding site (CTCF3) in the imprinting control region (ICR) upstream of H19. |
22395465 |
LncRNADisease
|
EL0556 |
H19 |
IGF2 |
RNA-Protein |
regulation |
H19 is an imprinted maternally expressed gene influencing IGF2 expression, whose transcript is a long noncoding (lnc) RNA of unknown biological function harboring the miR-675. |
22527881 |
|
EL0556 |
H19 |
H19 transcript can counteract 91H-mediated Igf2 activation |
RNA-RNA |
regulation |
A large excess of the H19 transcript can counteract 91H-mediated Igf2 activation. |
22662250 |
|
EL0556 |
H19 |
Igf2 |
RNA-Protein |
regulation |
Ectopic expression of the mouse 91H RNA can up-regulate Igf2 expression in trans |
22662250 |
|
EL0556 |
H19 |
let-7 family of microRNAs |
RNA-RNA |
binding |
Vertebrate H19 harbors both canonical and noncanonical binding sites for the let-7 family of microRNAs, which plays important roles in development, cancer, and metabolism. |
24055342 |
|
EL0556 |
H19 |
H1.3 |
RNA-Protein |
regulation |
H1.3dramatically inhibits H19 expression, which contributes to the suppression of epithelial ovarian carcinogenesis. |
25205099 |
|
EL0556 |
H19 |
K homology-type splicing regulatory protein (KSRP) |
RNA-Protein |
binding |
KSRP directly binds to H19 in the cytoplasm of undifferentiated multipotent mesenchymal C2C12 cells |
25385579 |
|
EL0556 |
H19 |
miR-138 and miR-200a |
RNA-RNA |
regulation |
by using bioinformatics study and RNA immunoprecipitation combined with luciferase reporter assays, we demonstrated that H19 functioned as a competing endogenous RNA (ceRNA) for miR-138 and miR-200a, antagonized their functions and led to the de-repression of their endogenous targets Vimentin, ZEB1, and ZEB2, all of which were core marker genes for mesenchymal cells |
26068968 |
|
EL0556 |
H19 |
MiR-141 |
RNA-RNA |
binding |
MiR-141 binds to H19 in a sequence specific manner, and suppresses H19 expression and functions including proliferation and invasion. MiR-141 could also regulate H19 target genes and miR-141 inhibitor restores H19 siRNA function, while H19 regulates miR-141 target gene ZEB1. |
26160158 |
|
EL0556 |
H19 |
Yes-associated protein 1 (YAP1) |
RNA-Protein |
co-expression |
H19 expression was found to be significantly associated with YAP1 expression. H19, at least in part, is induced by YAP1 overexpression. |
26163939 |
|
EL0556 |
H19 |
miR-675 |
RNA-RNA |
regulation |
Ectopic expression of H19 significantly increased bladder cancer cell proliferation and miR-675 expression in vitro. |
26198047 |
|
EL0556 |
H19 |
histone deacetylase (HDAC) 4/5 |
RNA-DNA |
regulation |
H19/miR-675 downregulated the mRNA and protein levels of histone deacetylase (HDAC) 4/5, and thus increased osteoblast marker gene expression. |
26417995 |
|
EL0556 |
H19 |
transforming growth factor-β1 (TGF-β1) |
RNA-DNA |
regulation |
H19/miR-675 inhibited mRNA and protein expression of transforming growth factor-β1 (TGF-β1). |
26417995 |
|
EL0556 |
H19 |
c-Myc |
RNA-Protein |
regulation |
H19 was a direct transcriptional target of c-Myc. |
26482621 |
|
EL0556 |
H19 |
S-adenosylhomocysteine hydrolase (SAHH) |
RNA-Protein |
binding |
The developmentally regulated H19 lncRNA binds to and inhibits S-adenosylhomocysteine hydrolase (SAHH), the only mammalian enzyme capable of hydrolysing S-adenosylhomocysteine (SAH) |
26687445 |
|
EL0556 |
H19 |
c-Myc |
DNA-DNA |
regulation |
The activity of the promoter of H19 was strengthened by c-Myc. |
26722426 |
|
EL0556 |
H19 |
miR-107 |
RNA-RNA |
regulation |
The expression of miR-107 increased or decreased with the overexpression and knockdown of H19, respectively. The number of cells in G2/M stage decreased significantly with the knockdown of H19 and miR-107 compared with the control group. |
26722426 |
|
EL0556 |
H19 |
heterogeneous nuclear ribonucleoprotein (hnRNP) U and actin |
RNA-Protein |
regulation |
H19 may inhibit the proliferation of fetal liver cells by blocking the interaction between heterogeneous nuclear ribonucleoprotein (hnRNP) U and actin, which results in gene transcriptional repression. |
26801864 |
|
EL0556 |
H19 |
AKT2 |
RNA-RNA |
co-expression |
The RNA levels of H19 and AKT2 were positively correlated. |
26803515 |
|
EL0556 |
H19 |
miR-141 and miR-22 |
RNA-RNA |
binding |
H19 functioned as an miRNA sponge for miR-141 and miR-22, both of which were negative regulators of osteogenesis and Wnt/β-catenin pathway. |
26853553 |
|
EL0556 |
H19 |
HuR |
RNA-Protein |
regulation |
H19 interacts with HuR and regulates the intestinal epithelial barrier function via the H19-encoded miR-675 by altering ZO-1 and E-cadherin expression posttranscriptionally. |
26884465 |
|
EL0556 |
H19 |
miR-675 |
RNA-RNA |
regulation |
H19 plays an important role in controlling the intestinal epithelial barrier function by serving as a precursor for microRNA 675 (miR-675). H19 overexpression increased the cellular abundance of miR-675, which in turn destabilized and repressed the translation of mRNAs encoding tight junction protein ZO-1 and adherens junction E-cadherin, resulting in the dysfunction of the epithelial barrier. |
26884465 |
|
EL0556 |
H19 |
RUNX1 |
RNA-DNA |
regulation |
Overexpression of H19 or miR-675 significantly decreased RUNX1 expression in AGS cells, and knockdown of H19 or miR-675 enhanced RUNX1 expression. |
26931432 |
|
EL0556 |
H19 |
miR-675 |
RNA-RNA |
regulation |
The expression of miR-675 was positively correlated with H19 in patients with gastric cancer. |
26931432 |
|
EL0556 |
H19 |
eIF4A3 |
RNA-Protein |
binding |
eIF4A3 as an RNA-binding protein that binds to H19. Combining eIF4A3 with H19 obstructed the recruitment of eIF4A3 to the cell-cycle gene mRNA. |
26989025 |
|
EL0556 |
H19 |
EZH2 |
RNA-DNA |
regulation |
H19 regulated EZH2 expression by suppressing the activity of miR-630, which is a repressor of EZH2 and interacts with H19 in a sequence-specific manner. |
27040767 |
|
EL0556 |
H19 |
miR-630 |
RNA-RNA |
regulation |
H19 regulated EZH2 expression by suppressing the activity of miR-630, which is a repressor of EZH2 and interacts with H19 in a sequence-specific manner. |
27040767 |
|
EL0556 |
H19 |
CaMKIIδ |
RNA-Protein |
regulation |
CaMKIIδ was a direct target of miR-675 and partially mediated the effect of H19 on cardiomyocyte hypertrophy. |
27084844 |
|
EL0556 |
H19 |
miR-675 |
RNA-RNA |
regulation |
H19 encoded miR-675. |
27084844 |
|
|