INTERACTION |
ID |
lncRNA Name |
Interaction target |
Level of interaction |
Type of interaction |
Description |
PMID |
Source |
EL0526 |
GAS5 |
NR3C1 |
RNA-Protein |
binding |
Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor. Gas5 bound to the DNA-binding domain of the glucocorticoid receptor (GR) by acting as a decoy glucocorticoid response element (GRE), thus competing with DNA GREs for binding to the GR. |
20124551 |
LncRNADisease
|
EL0526 |
GAS5 |
NR3C1 |
RNA-Protein |
regulation |
The multifunctional GAS5 lncRNA is a negative regulator of the glucocorticoid receptor and other nuclear receptors. |
20951849 |
LncRNADisease
|
EL0526 |
GAS5 |
miR-21 |
RNA-RNA |
regulation |
miR-21 is capable of suppressing the lncRNA growth arrest-specific 5 (GAS5). GAS5 can also repress miR-21 expression. |
23933812 |
|
EL0526 |
GAS5 |
Annexin A2 |
RNA-Protein |
binding |
RNA pull-down experiment revealed a direct bind of lncRNA-GAS5 to a Ca2+-dependent RNA-binding protein, Annexin A2. |
25806802 |
|
EL0526 |
GAS5 |
IGF-1R |
RNA-DNA |
regulation |
GAS5 overexpression was inversely correlated with the expression of the EGFR pathway and IGF-1R proteins. |
25925741 |
|
EL0526 |
GAS5 |
Y-box binding protein 1 (YBX1) |
RNA-Protein |
binding |
lncRNA GAS5 was shown to interact with Y-box binding protein 1 (YBX1), and lncRNA GAS5 knockdown was shown to accelerate YBX1 protein turnover without affecting YBX1 transcription. |
25959498 |
|
EL0526 |
GAS5 |
Plexin C1 |
RNA-Protein |
regulation |
The introduction of Gas5 by plasmid transfection increased the expression of tumor suppressor Bcl-2-modifying factor (bmf) and Plexin C1 via directly targeting and reducing the expression of miR-222. |
26364613 |
|
EL0526 |
GAS5 |
tumor suppressor Bcl-2-modifying factor (bmf) |
RNA-Protein |
regulation |
The introduction of Gas5 by plasmid transfection increased the expression of tumor suppressor Bcl-2-modifying factor (bmf) and Plexin C1 via directly targeting and reducing the expression of miR-222. |
26364613 |
|
EL0526 |
GAS5 |
miR-21 |
RNA-RNA |
regulation |
Thus, GAS5 acts as a tumor suppressor in HCCs through negative regulation of miR-21 and its targets and proteins about migration and invasion in cancer cells. |
26404135 |
|
EL0526 |
GAS5 |
miR-222 |
RNA-RNA |
binding |
A pulldown assay further validated that GAS5 could directly bind to miR-222. |
26446789 |
|
EL0526 |
GAS5 |
BAX, BAK, cleaved-caspase 3 and cleaved-caspase 9 |
RNA-Protein |
regulation |
GAS5 could disrupt mitochondrial membrane potential and promote BAX, BAK, cleaved-caspase 3 and cleaved-caspase 9 expression. |
26503132 |
|
EL0526 |
GAS5 |
miR-103 |
RNA-RNA |
regulation |
Through inhibiting the expression of miR-103, GAS5 significantly enhanced the expression of PTEN to promote cancer cell apoptosis. |
26511107 |
|
EL0526 |
GAS5 |
Ki67 |
RNA-Protein |
regulation |
Lower GAS5 levels appeared in the patients with a high Ki67 proliferation index before surgery |
26662314 |
|
EL0526 |
GAS5 |
vimentin |
RNA-Protein |
regulation |
GAS5 negatively regulates vimentin expression in vitro and in vivo. Notably, vimentin knockdown promoted GAS5‑pcDNA3.1‑inhibition of hepatoma cell proliferation. |
26707238 |
|
EL0526 |
GAS5 |
MMP2 |
RNA-Protein |
regulation |
Overexpressing lncRNA GAS5 inhibited the migration and invasion ability of melanoma SK-Mel‑110 cells, partially by decreasing the MMP2 expression and its activity. |
26846479 |
|
EL0526 |
GAS5 |
phosphatase and tensin homologs (PTEN) |
RNA-Protein |
regulation |
GAS5 suppresses cancer proliferation by acting as a molecular sponge for miR-21, leading to the de-repression of phosphatase and tensin homologs (PTEN), the endogenous target of miR-21. |
27034004 |
|
EL0526 |
GAS5 |
miR-21 |
RNA-RNA |
binding |
GAS5 suppresses cancer proliferation by acting as a molecular sponge for miR-21, leading to the de-repression of phosphatase and tensin homologs (PTEN), the endogenous target of miR-21. |
27034004 |
|
|