INTERACTION |
ID |
lncRNA Name |
Interaction target |
Level of interaction |
Type of interaction |
Description |
PMID |
Source |
EL0486 |
FALEC |
ECM1 |
RNA-RNA |
co-expression |
Depletion of ncRNA-a1 (activating long ncRNA 1, LINC00568), results in decreased ECM1 levels, suggesting a direct activating function of ncRNA-a1 on its neighboring gene. |
21502407 |
LncRNADisease
|
EL0486 |
FALEC |
BMI1 |
RNA-DNA |
regulation |
FAL1 associates with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes including CDKN1A. |
25203321 |
|
EL0486 |
FALEC |
p21 |
RNA-DNA |
regulation |
The oncogenic activity of FAL1 is partially attributable to its repression of p21. |
25203321 |
|
EL0486 |
FALEC |
BMI1 |
RNA-Protein |
regulation |
The oncogenic activity of FAL1 was mediated in part by its interaction with BMI1, a component of the chromatin-modifying Polycomb repressive complex 1, which resulted in increased stabilization of BMI1 protein and transcriptional repression of genes involved in processes such as cell proliferation and apoptosis. |
25367941 |
|
|