Related LncRNAs | |||||||||
---|---|---|---|---|---|---|---|---|---|
ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
EL1368 | TSIX | systemic sclerosis | real-time PCR and in situ hybridization, immunoblotting | dermal fibroblasts, serum | up-regulated | interaction | TSIX siRNA reduced the mRNA expression of type I collagen in normal and SSc dermal fibroblasts, but not the levels of major disease-related cytokines. In addition, TSIX siRNA significantly reduced type I collagen mRNA stability, but not protein half-lives. TSIX is a new regulator of collagen expression which stabilizes the collagen mRNA. | 26566700 | |