| Related LncRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
| EL0215 | ATXN7L3B | spinocerebellar ataxia type 7 | N/A | N/A | N/A | N/A | STAGA is required for the transcription initiation of miR-124, which in turn mediates the post-transcriptional cross-talk between lnc-SCA7, a conserved long noncoding RNA,and ATXN7 mRNA. In SCA7, mutations in ATXN7 disrupt these regulatory interactions and result in a neuron-specific increase in ATXN7 expression. Strikingly, in mice this increase is most prominent in the SCA7 disease-relevant tissues, namely the retina and cerebellum. | 25306109 | LncRNADisease |
| EL1171 | RRP1B | Spinocerebellar ataxia type 7 | N/A | N/A | N/A | expression | CTCF is required for SCAANT1 expression. Loss of SCAANT1 derepressed ataxin-7 sense transcription in a cis-dependent fashion and was accompanied by chromatin remodeling. | 21689595 | LncRNADisease |
| EL1171 | RRP1B | Spinocerebellar ataxia type 7 | N/A | N/A | N/A | mutation | For example, SCA7/ATXN7 antisense RNA 1 (SCAANT1) is an lncRNA transcribed antisense to the gene mutated in spinocerebellar ataxia type 7 (ATXN7), and it functions as a repressor of ATXN7 transcription | 22814587 | LncRNADisease |
| EL1171 | RRP1B | Spinocerebellar ataxia type 7 | N/A | N/A | N/A | regulation | Genomic context links lncRNAs to disease genes/loci and related pathways | 23791884 | LncRNADisease |
| EL1171 | RRP1B | Spinocerebellar ataxia type 7 | N/A | N/A | N/A | expression | Long ncRNA SCAANT1 is implicated in a type of polyglutamine disorder, spinocerebellar ataxia type 7 (SCA7). | 24624135 | LncRNADisease |