Related LncRNAs |
ID |
lncRNA Name |
Disease |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
EL0215 |
ATXN7L3B |
spinocerebellar ataxia type 7 |
N/A |
N/A |
N/A |
N/A |
STAGA is required for the transcription initiation of miR-124, which in turn mediates the post-transcriptional cross-talk between lnc-SCA7, a conserved long noncoding RNA,and ATXN7 mRNA. In SCA7, mutations in ATXN7 disrupt these regulatory interactions and result in a neuron-specific increase in ATXN7 expression. Strikingly, in mice this increase is most prominent in the SCA7 disease-relevant tissues, namely the retina and cerebellum. |
25306109 |
LncRNADisease
|
EL1171 |
RRP1B |
Spinocerebellar ataxia type 7 |
N/A |
N/A |
N/A |
expression |
CTCF is required for SCAANT1 expression. Loss of SCAANT1 derepressed ataxin-7 sense transcription in a cis-dependent fashion and was accompanied by chromatin remodeling. |
21689595 |
LncRNADisease
|
EL1171 |
RRP1B |
Spinocerebellar ataxia type 7 |
N/A |
N/A |
N/A |
mutation |
For example, SCA7/ATXN7 antisense RNA 1 (SCAANT1) is an lncRNA transcribed antisense to the gene mutated in spinocerebellar ataxia type 7 (ATXN7), and it functions as a repressor of ATXN7 transcription |
22814587 |
LncRNADisease
|
EL1171 |
RRP1B |
Spinocerebellar ataxia type 7 |
N/A |
N/A |
N/A |
regulation |
Genomic context links lncRNAs to disease genes/loci and related pathways |
23791884 |
LncRNADisease
|
EL1171 |
RRP1B |
Spinocerebellar ataxia type 7 |
N/A |
N/A |
N/A |
expression |
Long ncRNA SCAANT1 is implicated in a type of polyglutamine disorder, spinocerebellar ataxia type 7 (SCA7). |
24624135 |
LncRNADisease
|
|