| Related LncRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
| EL0521 | GADD45G | pituitary adenoma | qPCR etc. | pituitary tumor tissue | down-regulated | N/A | In summary, MEG3 and GADD45γexpression was significantly lost in most clinically non-functioning adenomas (78 and 92%, respetcively). Other assessed pituitary tumor phenotypes expressed both genes at significantly different levels, and, in some cases, with overexpression. | 21850407 | Lnc2Cancer |
| EL0556 | H19 | pituitary adenoma | N/A | N/A | N/A | regulation | Epigenetic deregulation of lncRNAs genes is associated with disease | 23791884 | LncRNADisease |
| EL0578 | HOTAIR | pituitary adenoma | qPCR etc. | pituitary adenomas tissue | up-regulated | expression | Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior. | 24469926 | LncRNADisease Lnc2Cancer |
| EL0853 | MALAT1 | pituitary adenoma | qPCR etc. | pituitary adenomas tissue | up-regulated | expression | Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior. | 24469926 | LncRNADisease Lnc2Cancer |
| EL0861 | MEG3 | pituitary adenoma | N/A | N/A | N/A | expression | Another potential angiogenic lncRNA, Maternally expressed gene 3 (MEG3) was found to be silenced in pituitary adenomas.? | 24829860 | LncRNADisease |
| EL0861 | MEG3 | pituitary adenoma | qPCR etc. | pituitary tumor tissue | down-regulated | N/A | In summary, MEG3 and GADD45γ expression was significantly lost in most clinically non-functioning adenomas (78 and 92%, respetcively). Other assessed pituitary tumor phenotypes expressed both genes at significantly different levels, and, in some cases, with overexpression. | 21850407 | Lnc2Cancer |
| EL0861 | MEG3 | pituitary adenoma | qPCR etc. | pituitary adenomas tissue | up-regulated | N/A | MEG3 lncRNA levels gradually decreased whereas HOTAIR lncRNA levels gradually increased from normal anterior pituitaries to non-invasive NFPAs to invasive NFPAs. There was a significant association between MEG3 (P < 0.01) and HOTAIR (P < 0.05) expression and the biological behavior of the tumor. Furthermore, PCNA mRNA levels markedly increased in invasive NFPAs compared to non-invasive ones (P < 0.01). In addition, PCNA mRNA negatively correlated with MEG3 lncRNA levels | 24469926 | LncRNADisease Lnc2Cancer |
| EL0861 | MEG3 | pituitary adenoma | qPCR, ISH etc. | pituitary tumor tissue | down-regulated | N/A | Therefore, RT-PCR was used to detect specific MEG3a isoform expression in different human pituitary tumor phenotypes. Figure 4B shows that there was no MEG3a expression in three GH-secreting tumors and eight clinically nonfunctioning pituitary tumors, in contrast to the five normal human pituitaries. | 14602737 | LncRNADisease Lnc2Cancer |