Related LncRNAs |
ID |
lncRNA Name |
Disease |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
EL0521 |
GADD45G |
pituitary adenoma |
qPCR etc. |
pituitary tumor tissue |
down-regulated |
N/A |
In summary, MEG3 and GADD45γexpression was significantly lost in most clinically non-functioning adenomas (78 and 92%, respetcively). Other assessed pituitary tumor phenotypes expressed both genes at significantly different levels, and, in some cases, with overexpression. |
21850407 |
Lnc2Cancer
|
EL0556 |
H19 |
pituitary adenoma |
N/A |
N/A |
N/A |
regulation |
Epigenetic deregulation of lncRNAs genes is associated with disease |
23791884 |
LncRNADisease
|
EL0578 |
HOTAIR |
pituitary adenoma |
qPCR etc. |
pituitary adenomas tissue |
up-regulated |
expression |
Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior. |
24469926 |
LncRNADisease Lnc2Cancer
|
EL0853 |
MALAT1 |
pituitary adenoma |
qPCR etc. |
pituitary adenomas tissue |
up-regulated |
expression |
Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior. |
24469926 |
LncRNADisease Lnc2Cancer
|
EL0861 |
MEG3 |
pituitary adenoma |
N/A |
N/A |
N/A |
expression |
Another potential angiogenic lncRNA, Maternally expressed gene 3 (MEG3) was found to be silenced in pituitary adenomas.? |
24829860 |
LncRNADisease
|
EL0861 |
MEG3 |
pituitary adenoma |
qPCR etc. |
pituitary tumor tissue |
down-regulated |
N/A |
In summary, MEG3 and GADD45γ expression was significantly lost in most clinically non-functioning adenomas (78 and 92%, respetcively). Other assessed pituitary tumor phenotypes expressed both genes at significantly different levels, and, in some cases, with overexpression. |
21850407 |
Lnc2Cancer
|
EL0861 |
MEG3 |
pituitary adenoma |
qPCR etc. |
pituitary adenomas tissue |
up-regulated |
N/A |
MEG3 lncRNA levels gradually decreased whereas HOTAIR lncRNA levels gradually increased from normal anterior pituitaries to non-invasive NFPAs to invasive NFPAs. There was a significant association between MEG3 (P < 0.01) and HOTAIR (P < 0.05) expression and the biological behavior of the tumor. Furthermore, PCNA mRNA levels markedly increased in invasive NFPAs compared to non-invasive ones (P < 0.01). In addition, PCNA mRNA negatively correlated with MEG3 lncRNA levels |
24469926 |
LncRNADisease Lnc2Cancer
|
EL0861 |
MEG3 |
pituitary adenoma |
qPCR, ISH etc. |
pituitary tumor tissue |
down-regulated |
N/A |
Therefore, RT-PCR was used to detect specific MEG3a isoform expression in different human pituitary tumor phenotypes. Figure 4B shows that there was no MEG3a expression in three GH-secreting tumors and eight clinically nonfunctioning pituitary tumors, in contrast to the five normal human pituitaries. |
14602737 |
LncRNADisease Lnc2Cancer
|
|