| Related LncRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
| EL0227 | BANCR | papillary thyroid carcinoma | qPCR, knockdown, RIP, FCA etc. | PTC tissue, cell line (IHH-4) | up-regulated | interaction | The expression of BANCR was significantly up-regulated while PTCSC3 and NAMA were significantly down-regulated in papillary thyroid carcinoma (PTC) compared to that in normal tissue. BANCR-knockdown in a PTC-derived cell line (IHH-4) resulted in significant suppression of thyroid stimulating hormone receptor (TSHR). BANCR-knockdown also led to inhibition of cell growth and cell cycle arrest at G0/G1 phase through down-regulation of cyclin D1. In addition, BANCR was enriched by polycomb enhancer of zeste homolog 2 (EZH2), and silencing BANCR led to decreased chromatin recruitment of EZH2, which resulted significantly reduced expression of TSHR. | 26323637 | Lnc2Cancer |
| EL0227 | BANCR | papillary thyroid carcinoma | qPCR, Western blot, FCA etc. | PTC tissue, cells line (IHH-4) | up-regulated | expression | The results revealed that BANCR levels were significantly higher in the PTC tissues and PTC IHH-4 cells compared with the normal controls. Knockdown of BANCR in the IHH-4 cells inhibited proliferation and increased apoptosis of the cells in vitro. Further investigation of the underlying mechanisms revealed that BANCR markedly activated autophagy. Overexpression of BANCR inhibited apoptosis in the IHH-4 cells, whereas inhibition of autophagy stimulated apoptosis in the BANCR-overexpressed cells. BANCR overexpression also increased cell proliferation and the inhibition of autophagy abrogated BANCR overexpression-induced cell proliferation. | 25289082 | Lnc2Cancer |
| EL0452 | LINC01384 | papillary thyroid carcinoma | microarray, qPCR etc. | papillary thyroid carcinoma tissue | down-regulated | expression | We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. | 26003293 | Lnc2Cancer |
| EL0468 | ENST00000537266 | papillary thyroid carcinoma | microarrays, CCK-8 assay, colony formation assay and EdU assay, Flow Cytometry, Transwell and scratch assay | Papillary thyroid cancer cell line | N/A | expression | lncRNAs (ENST00000537266 and ENST00000426615) could inhibit cell proliferation. lncRNAs (ENST00000426615 and ENST00000537266) might be important regulators of PTC cell proliferation and motility, which might provide new insight into the understanding of PTC pathogenesis. | 26824456 | |
| EL0486 | FALEC | papillary thyroid carcinoma | qRT-PCR | PTC and normal thyroid tissues | up-regulated | N/A | FAL1 expression was significantly higher in PTC | 26825907 | |
| EL0529 | GAS8-AS1 | papillary thyroid carcinoma | NGS | Chinese PTC using 402 tumor-normal pairs | N/A | N/A | higher capability to inhibit cancer cell growth | 26941397 | |
| EL0559 | HAGLROS | papillary thyroid carcinoma | microarrays, CCK-9 assay, colony formation assay and EdU assay, Flow Cytometry, Transwell and scratch assay | Papillary thyroid cancer cell line | N/A | expression | lncRNAs (ENST00000537266 and ENST00000426615) could inhibit cell proliferation. lncRNAs (ENST00000426615 and ENST00000537266) might be important regulators of PTC cell proliferation and motility, which might provide new insight into the understanding of PTC pathogenesis. ENST00000426615 could inhibit the cell motility | 26824456 | |
| EL0578 | HOTAIR | papillary thyroid carcinoma | microarray, qPCR etc. | papillary thyroid carcinoma tissue | up-regulated | expression | Expression profiles of five lnc-RNAs (MEG3, HULC, HOTAIR, NEAT1, and MALAT-1) previously shown to be involved in cancer metastasis were detected by qPCR in 5 pairs of papillary thyroid cancer and 11 matched lymph node metastatic tissues. Among the five, MEG3 showed significant down-expression. Overexpression of MEG3 inhibits thyroid cancer cell migration and invasion. | 25997963 | Lnc2Cancer |
| EL0600 | HULC | papillary thyroid carcinoma | microarray, qPCR etc. | papillary thyroid carcinoma tissue | up-regulated | expression | Expression profiles of five lnc-RNAs (MEG3, HULC, HOTAIR, NEAT1, and MALAT-1) previously shown to be involved in cancer metastasis were detected by qPCR in 5 pairs of papillary thyroid cancer and 11 matched lymph node metastatic tissues. Among the five, MEG3 showed significant down-expression. Overexpression of MEG3 inhibits thyroid cancer cell migration and invasion. | 25997963 | Lnc2Cancer |
| EL0645 | LGALS3 | papillary thyroid carcinoma | microarray, qPCR etc. | papillary thyroid carcinoma tissue | up-regulated | expression | We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. | 26003293 | Lnc2Cancer |
| EL0772 | lnc-KCMF1-2:1 | papillary thyroid carcinoma | microarray, qPCR etc. | papillary thyroid carcinoma tissue | down-regulated | expression | We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. | 26003293 | Lnc2Cancer |
| EL0776 | lnc-LLPH-2:1 | papillary thyroid carcinoma | microarray, qPCR etc. | papillary thyroid carcinoma tissue | up-regulated | expression | We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. | 26003293 | Lnc2Cancer |
| EL0778 | lnc-PLA2R1-1:1 | papillary thyroid carcinoma | microarray, qPCR etc. | papillary thyroid carcinoma tissue | down-regulated | expression | We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. | 26003293 | Lnc2Cancer |
| EL0779 | lnc-PSD4-1:14 | papillary thyroid carcinoma | microarray, qPCR etc. | papillary thyroid carcinoma tissue | down-regulated | expression | We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. | 26003293 | Lnc2Cancer |
| EL0853 | MALAT1 | papillary thyroid carcinoma | microarray, qPCR etc. | papillary thyroid carcinoma tissue | down-regulated | expression | Expression profiles of five lnc-RNAs (MEG3, HULC, HOTAIR, NEAT1, and MALAT-1) previously shown to be involved in cancer metastasis were detected by qPCR in 5 pairs of papillary thyroid cancer and 11 matched lymph node metastatic tissues. Among the five, MEG3 showed significant down-expression. Overexpression of MEG3 inhibits thyroid cancer cell migration and invasion. | 25997963 | Lnc2Cancer |
| EL0861 | MEG3 | papillary thyroid carcinoma | microarray, qPCR etc. | papillary thyroid carcinoma tissue | down-regulated | interaction | Expression profiles of five lnc-RNAs (MEG3, HULC, HOTAIR, NEAT1, and MALAT-1) previously shown to be involved in cancer metastasis were detected by qPCR in 5 pairs of papillary thyroid cancer and 11 matched lymph node metastatic tissues. Among the five, MEG3 showed significant down-expression. Overexpression of MEG3 inhibits thyroid cancer cell migration and invasion.Thus, this study suggests that MEG3 acts as novel suppressor of migration and invasion by targeting Rac1 gene. | 25997963 | Lnc2Cancer |
| EL0956 | n335550 | papillary thyroid carcinoma | microarray, qPCR etc. | papillary thyroid carcinoma tissue | down-regulated | expression | We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. | 26003293 | Lnc2Cancer |
| EL0957 | n340790 | papillary thyroid carcinoma | microarray, qPCR etc. | papillary thyroid carcinoma tissue | up-regulated | expression | We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. | 26003293 | Lnc2Cancer |
| EL0958 | n386477 | papillary thyroid carcinoma | microarray, qPCR etc. | papillary thyroid carcinoma tissue | up-regulated | expression | We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. | 26003293 | Lnc2Cancer |
| EL0960 | NAMA | papillary thyroid carcinoma | qPCR, knockdown, RIP, FCA etc. | PTC tissue, cell line (IHH-4) | down-regulated | expression | The expression of BANCR was significantly up-regulated while PTCSC3 and NAMA were significantly down-regulated in papillary thyroid carcinoma (PTC) compared to that in normal tissue. | 26323637 | Lnc2Cancer |
| EL0960 | NAMA | papillary thyroid carcinoma | qPCR, Western blot, Northern blot, knockdown etc. | PTA tissue tissue, cell lines (NPA87, K1, K2 etc.) | down-regulated | expression | Identification of a novel noncoding RNA gene, NAMA, that is downregulated in papillary thyroid carcinoma with BRAF mutation and associated with growth arrest. | 17415708 | LncRNADisease Lnc2Cancer |
| EL0973 | NEAT1 | papillary thyroid carcinoma | microarray, qPCR etc. | papillary thyroid carcinoma tissue | up-regulated | expression | Expression profiles of five lnc-RNAs (MEG3, HULC, HOTAIR, NEAT1, and MALAT-1) previously shown to be involved in cancer metastasis were detected by qPCR in 5 pairs of papillary thyroid cancer and 11 matched lymph node metastatic tissues. Among the five, MEG3 showed significant down-expression. Overexpression of MEG3 inhibits thyroid cancer cell migration and invasion. | 25997963 | Lnc2Cancer |
| EL0980 | NONHSAT037832 | papillary thyroid carcinoma | qPCR etc. | PTC tissue, cell line (IHH-4, K1, B-CPAP, Nthyori 3-1) | down-regulated | expression | The results suggested that the expression level of NONHSAT037832 was significantly decreased in PTC compared with paired noncancerous tissues (P < 0.01). And, NONHSAT037832 was also significantly downregulated in two PTC cell lines (K1 and IHH-4) compared to normal thyroid follicular epithelial cell line Nthy-ori 3-1 (P < 0.01). Downregulated NONHSAT037832 was significantly associated with lymph node metastasis (P = 0.015) and tumor size (P = 0.032). | 26611646 | Lnc2Cancer |
| EL1094 | PTCSC1 | papillary thyroid carcinoma | qPCR etc. | PTA tissue tissue | up-regulated | expression | Gene expression analysis indicated that AK023948 is significantly down-regulated in most PTC tumors. The putative noncoding RNA gene AK023948 is a candidate susceptibility gene for PTC. | 19147577 | LncRNADisease Lnc2Cancer |
| EL1095 | PTCSC2 | papillary thyroid carcinoma | microarray, qPCR etc. | PTC tissue, blood | down-regulated | expression | Transcripts of PTCSC2 are down-regulated in PTC tumors. We also observed a significant association of age and CLT with PTCSC2 unspliced transcript levels.Forced expression of PTCSC2 in the BCPAP cell line affected the expression of a subset of non-coding and coding transcripts with enrichment of genes functionally involved in cell cycle and cancer. | 25303483 | Lnc2Cancer |
| EL1096 | PTCSC3 | papillary thyroid carcinoma | microarray, qPCR, Western blot etc. | thyroid cancer tissue, cell line (TPC-1) | up-regulated | interaction | Expression data from PTC cell lines pinpointed S100A4 as the most significantly downregulated gene in the presence of PTCSC3. S100A4 was upregulated in tumor tissue while PTCSC3 was strongly downregulated. S100A4 transcription was moderately correlated with PTCSC3 expression in unaffected thyroid tissue, and strongly in unaffected tissue of patients with the risk allele of rs944289. S100A4, VEGF and MMP-9 were suppressed in the presence of PTCSC3. PTC cells expressing PTCSC3 showed reduction in motility and invasiveness. | 26274343 | Lnc2Cancer |
| EL1096 | PTCSC3 | papillary thyroid carcinoma | N/A | N/A | N/A | mutation | A thyroid-specific lncRNA, termed PTC susceptibility candidate 3 (PTCSC3), that was strongly downregulated in PTC was identified in this region and it was found that the repression was caused by the associated SNP. | 23660942 | LncRNADisease |
| EL1096 | PTCSC3 | papillary thyroid carcinoma | N/A | N/A | N/A | expression | The study showed that the expression of PTCSC3 in six thyroid cancer cell lines is lower and no expression was detected in any of them.? | 24817925 | LncRNADisease |
| EL1096 | PTCSC3 | papillary thyroid carcinoma | qPCR, knockdown, RIP, FCA etc. | PTC tissue, cell line (IHH-4) | down-regulated | expression | The expression of BANCR was significantly up-regulated while PTCSC3 and NAMA were significantly down-regulated in papillary thyroid carcinoma (PTC) compared to that in normal tissue. | 26323637 | Lnc2Cancer |
| EL1314 | TCONS_l2_00010365 | papillary thyroid carcinoma | microarray, qPCR etc. | papillary thyroid carcinoma tissue | up-regulated | expression | We randomly chose a total of 10 differentially expressed lncRNAs for qPCR, of which TCONS_l2_00010365, n386477, n340790, lnc-LLPH-2:1 and NR_003225.2 were up-regulated and lnc-PSD4-1:14, n335550, lnc-KCMF1-2:1, lnc-PLA2R1-1:1 and ENST00000422494.1 were down-regulated in PTC. The results of qPCR were consistent with those of the microarray, in that all 10 lncRNAs were differentially expressed with the same trend (up- or down-regulated) and reached statistical significance. | 26003293 | Lnc2Cancer |