| Related LncRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
| EL0040 | AFAP1-AS1 | pancreatic ductal adenocarcinoma | qPCR etc. | blood, cell lines (Panc1, MIAPaCa-2, Capan2, SW1990 etc.) | up-regulated | expression | Microarray analysis revealed that up-regulation of AFAP1-AS1 expression in PDAC tissues compared with normal adjacent tissues, which was confirmed by RT-qPCR in 69/90 cases (76.7%). Its overexpression was associated with lymph node metastasis, perineural invasion, and poor survival. AFAP1-AS1 is a potential novel prognostic marker to predict the clinical outcome of PDAC patients after surgery and may be a rational target for therapy. | 25925763 | Lnc2Cancer |
| EL0331 | DAPK1 | pancreatic ductal adenocarcinoma | microarray, qPCR etc. | cell line (MIA PaCa-2 ) | up-regulated | expression | Differential expression | 22078386 | LncRNADisease Lnc2Cancer |
| EL0556 | H19 | pancreatic ductal adenocarcinoma | qPCR, Western blot, knockdown etc. | pancreatic cancer tissue, cell lines (PANC-1, SW1990, AsPC-1, BxPC-3, CFPAC-1 etc.) | up-regulated | N/A | The levels of H19 was overexpressed in PDAC and was upregulated remarkably in primary tumors which subsequently metastasized, compared to those did not metastasis. H19 promoted PDAC cell invasion and migration. An important role of H19 in regulating metastasis of PDAC and provides some clues for elucidating the lncRNAmiRNA functional network in cancer. | 24920070 | Lnc2Cancer |
| EL0580 | HOTAIRM1 | pancreatic ductal adenocarcinoma | N/A | pancreatic ductal adenocarcinoma (PDAC) tissues | up-regulated | expression | The expression level of long intergenic non-coding RNA HOTAIRM1 was upregulated in 12 PDAC tissues samples compared with matched adjacent non-tumor samples by qRT-PCR. The revelation of an association between HOTAIRM1 expression and PDAC is especially noteworthy. | 26676849 | |
| EL0582 | HOTTIP | pancreatic ductal adenocarcinoma | microarray, qRT-PCR | eight human pancreatic ductal adenocarcinoma (PDAC) tissues and four pancreatic tissues. | up-regulated | expression | Functionally, HOTTIP silencing resulted in proliferation arrest by altering cell-cycle progression, and impaired cell invasion by inhibiting epithelial-mesenchymal transition in pancreatic cancer. HOTTIP promotes cell proliferation, invasion, and chemoresistance by modulating HOXA13. Therefore, the HOTTIP/HOXA13 axis is a potential therapeutic target and molecular biomarker for PDAC. | 25889214 | |
| EL0659 | LINC00491 | pancreatic ductal adenocarcinoma | microarray, qPCR etc. | PDAC tissue | down-regulated | expression | We found that the expression level of lncRNA BC008363 was significantly lower (23-fold) in PDAC tissues compared to corresponding nontumor pancreatic tissues, and patients with high levels of lncRNA BC008363 expression had significantly better survival rates than those with low levels of lncRNA BC008363 expression. lncRNA BC008363 may be a novel biomarker for the prognosis of pancreatic cancer. | 25200694 | Lnc2Cancer |
| EL0829 | AC100861.1 | pancreatic ductal adenocarcinoma | knockdown, overexpression | pancreatic ductal adenocarcinoma (PDAC) tissues and cell lines | up-regulated | interaction | Knockdown of LOC389641 impaired cell proliferation and invasion and induced cell apoptosis in vitro, whereas overexpression of LOC389641 had the opposite effect. LOC389641 promotes PDAC progression and increases cell invasion by regulating E-cadherin with the possible involvement of TNFRSF10A. | 26708505 | |
| EL0853 | MALAT1 | pancreatic ductal adenocarcinoma | qPCR etc. | PADC tissue, cell lines (Panc-1, Bxpc-3, HPDE6C-7 etc.) | up-regulated | N/A | The relative level of MALAT1 was significantly higher in PDAC compared to the adjacent normal pancreatic tissues. When comparing the MALAT1 level in the cultured cell lines, remarkably higher expression of MALAT1 was found in aspc-1 PDAC cells compared with the immortal pancreatic duct epithelial cell line HPDE6c-7. Furthermore, MALAT1 expression level showed significant correlation with tumor size, tumor stage and depth of invasion. Kaplan-Meier analysis revealed that patients with higher MALAT1 expression had a poorer disease free survival. | 24815433 | Lnc2Cancer |
| EL0856 | MAP3K14 | pancreatic ductal adenocarcinoma | microarray, qPCR etc. | cell line (MIA PaCa-2 ) | up-regulated | expression | Differential expression | 22078386 | LncRNADisease Lnc2Cancer |
| EL1023 | OS9 | pancreatic ductal adenocarcinoma | qPCR, Western blot, Luciferase reporter assay, ELISA etc. | PDAC tissue | down-regulated | N/A | the ENST00000480739 expression level was remarkably | 25314054 | LncRNADisease Lnc2Cancer |
| EL1081 | PPP3CB | pancreatic ductal adenocarcinoma | microarray, qPCR etc. | cell line (MIA PaCa-2 ) | up-regulated | expression | Differential expression | 22078386 | LncRNADisease Lnc2Cancer |
| EL1102 | PVT1 | pancreatic ductal adenocarcinoma | qPCR etc. | PDAC tissue | up-regulated | expression | The study results showed that the PVT1 expression was significantly increased in PDAC tissues compared to adjacent nontumor tissues. The expression of PVT1 was associated with clinical stage and N-classification (P<0.05). Patients with high PVT1 expression level had shorter overall survival times compared to those with low PVT1 expression level (P<0.05). | 25668599 | Lnc2Cancer |