| Related LncRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
| EL0035 | AF075041 | pancreatic cancer | qPCR etc. | pancreatic cancer tissue, cell lines (Sw1990, PANC-1, BXPC-3 etc.) | up-regulated | expression | We further confirmed the selected 6 up-regulation of LncRNAs in PC tissues and PC cell lines through qPCR. Comparing to 293T cells, the expression of LncRNA AF339813 was significantly increased about 10-fold in PANC-1 cells, 8-fold in SW1990 cells and 8.9-fold in BxCP-3 cells. The other 5 LncRNAs have a certain degree of up-regulation in PC cell lines. | 26045769 | Lnc2Cancer |
| EL0039 | AF339813 | pancreatic cancer | qPCR, Western blot, knockdown etc. | pancreatic cancer tissue, cell lines (Sw1990, PANC-1, BXPC-4 etc.) | up-regulated | interaction | We found LncRNA AF339813 was positively regulated by NUF2. We further demonstrated that knockdown of AF339813 by siRNA in PC cells significantly reduced cell proliferation and promoted apoptosis.We further demonstrated that knockdown of AF339813 by siRNA in PC cells significantly reduced cell proliferation and promoted apoptosis. Thus, we conclude that NUF2 is consistently overexpressed in human PC and NUF2 is closely linked with human PC progression through the meditator LncRNA AF339813. | 26045769 | Lnc2Cancer |
| EL0045 | AK022029 | pancreatic cancer | qPCR etc. | pancreatic cancer tissue, cell lines (Sw1990, PANC-1, BXPC-5 etc.) | up-regulated | expression | We further confirmed the selected 6 up-regulation of LncRNAs in PC tissues and PC cell lines through qPCR. Comparing to 293T cells, the expression of LncRNA AF339813 was significantly increased about 10-fold in PANC-1 cells, 8-fold in SW1990 cells and 8.9-fold in BxCP-3 cells. The other 5 LncRNAs have a certain degree of up-regulation in PC cell lines. | 26045769 | Lnc2Cancer |
| EL0046 | AK022159 | pancreatic cancer | qPCR etc. | pancreatic cancer tissue, cell lines (Sw1990, PANC-1, BXPC-6 etc.) | up-regulated | expression | We further confirmed the selected 6 up-regulation of LncRNAs in PC tissues and PC cell lines through qPCR. Comparing to 293T cells, the expression of LncRNA AF339813 was significantly increased about 10-fold in PANC-1 cells, 8-fold in SW1990 cells and 8.9-fold in BxCP-3 cells. The other 5 LncRNAs have a certain degree of up-regulation in PC cell lines. | 26045769 | Lnc2Cancer |
| EL0067 | AL389956 | pancreatic cancer | qPCR etc. | pancreatic cancer tissue, cell lines (Sw1990, PANC-1, BXPC-7 etc.) | up-regulated | expression | We further confirmed the selected 6 up-regulation of LncRNAs in PC tissues and PC cell lines through qPCR. Comparing to 293T cells, the expression of LncRNA AF339813 was significantly increased about 10-fold in PANC-1 cells, 8-fold in SW1990 cells and 8.9-fold in BxCP-3 cells. The other 5 LncRNAs have a certain degree of up-regulation in PC cell lines. | 26045769 | Lnc2Cancer |
| EL0232 | BC023629 | pancreatic cancer | qPCR etc. | pancreatic cancer tissue, cell lines (Sw1990, PANC-1, BXPC-8 etc.) | up-regulated | expression | We further confirmed the selected 6 up-regulation of LncRNAs in PC tissues and PC cell lines through qPCR. Comparing to 293T cells, the expression of LncRNA AF339813 was significantly increased about 10-fold in PANC-1 cells, 8-fold in SW1990 cells and 8.9-fold in BxCP-3 cells. The other 5 LncRNAs have a certain degree of up-regulation in PC cell lines. | 26045769 | Lnc2Cancer |
| EL0303 | CR619813 | pancreatic cancer | microarray, qPCR etc. | cell lines (SW1990, SWl990/GZ etc.) | down-regulated | expression | Six lncRNAs (RP11-58D2.1, lincRNA-ZNF532, AP000221.1, CTC-338M12.5, CR619813, DDX6P) were selected to validate the microarray consistency by using qPCR. The results demonstrated that RP11-58D2.1, lincRNA-ZNF532 and AP000221.1 were upregulated and that CTC-338M12.5, DDX6P and CR619813 were downregulated in the SW1990/GZ cells compared with SW1990 cells (Figure 6). | 25755691 | Lnc2Cancer |
| EL0325 | CYTOR | pancreatic cancer | qPCR, Western blot, knockdown etc. | PDAC tissue | up-regulated | expression | The upregulation of LINC00152 (MACE log2fc: 2.3, qPCR: 1.5) and downregulation of LINC00261 (MACE log2fc: 5.3, qPCR: 4.4) in PDAC tissues was confirmed by qPCR. | 25910082 | Lnc2Cancer |
| EL0335 | DDX6P1 | pancreatic cancer | microarray, qPCR etc. | cell lines (SW1990, SWl990/GZ etc.) | down-regulated | expression | Six lncRNAs (RP11-58D2.1, lincRNA-ZNF532, AP000221.1, CTC-338M12.5, CR619813, DDX6P) were selected to validate the microarray consistency by using qPCR. The results demonstrated that RP11-58D2.1, lincRNA-ZNF532 and AP000221.1 were upregulated and that CTC-338M12.5, DDX6P and CR619813 were downregulated in the SW1990/GZ cells compared with SW1990 cells (Figure 6). | 25755691 | Lnc2Cancer |
| EL0526 | GAS5 | pancreatic cancer | qPCR, Western bolt etc. | pancreatic cancer tissue, cell lines (BxPC-3, PANC-1, AsPC-1, Hs766T etc.) | down-regulated | N/A | We verify that the expression level of gas5 is significantly decreased in pancreatic cancer tissues compared with normal control. Overexpression of gas5 in pancreatic cancer cells inhibits cell proliferation, whereas gas5 inhibition induces a significant decrease in G0/G1 phase and an increase in S phase. We further demonstrate that gas5 negatively regulates CDK6 expression in vitro and in vivo. More importantly, knockdown of CDK6 partially abrogates gas5-siRNA-induced cell proliferation. | 24026436 | Lnc2Cancer |
| EL0578 | HOTAIR | pancreatic cancer | N/A | N/A | N/A | expression | In approximately one-quarter of human breast cancers, HOTAIR is highly induced, while its elevated levels are also predictive of metastasis and disease progression in other cancers, such as colon, colorectal, gastrointestinal, pancreatic and liver cancer. | 24667321 | LncRNADisease |
| EL0578 | HOTAIR | pancreatic cancer | qPCR, Luciferase reporter assay, in vitro knockdown etc. | cell lines (Panc1, MiaPaCa2, Panc28, L3.6pl) | up-regulated | N/A | We show that HOTAIR expression is increased in pancreatic tumors compared with non-tumor tissue and is associated with more aggressive tumors. Knockdown of HOTAIR (siHOTAIR) by RNA interference shows that HOTAIR has an important role in pancreatic cancer cell invasion, as reported in other cancer cell lines. HOTAIR knockdown in Panc1 and L3.6pL pancreatic cancer cells that overexpress this lincRNA decreased cell proliferation, altered cell cycle progression and induced apoptosis, demonstrating an expanded function of HOTAIR in pancreatic cancer cells compared with other cancer cell lines. HOTAIR uniquely suppressed several interferon-related genes and gene sets related to cell cycle progression in pancreatic cancer cells and tumors. | 22614017 | Lnc2Cancer |
| EL0582 | HOTTIP | pancreatic cancer | microarray, qPCR, Western blot, knockdown etc. | cell lines (Panc1, ASPC1, BxPC3 etc.) | up-regulated | interaction | HOTTIP is expressed in pancreatic cancer cell lines and knockdown of HOTTIP by RNA interference (siHOTTIP) in Panc1 pancreatic cancer cells decreased proliferation, induced apoptosis and decreased migration. HOTTIP functions in pancreatic cancer cells are due, in part, to regulation of some HOX genes including HOXA10, HOXB2, HOXA11, HOXA9 and HOXA1. | 25912306 | Lnc2Cancer |
| EL0600 | HULC | pancreatic cancer | qPCR, knockdown etc. | pancreatic cancer tissue, cell lines (MIAPace-2, CFPAC-1, PANC-1, AsPC-1 etc.) | up-regulated | expression | The higher expression of HULC was significantly correlated with large tumor size, advanced lymph node metastasis and vascular invasion. Multivariate analyses revealed that HULC expression served as an independent predictor for overall survival. Further experiments revealed that HULC knockdown significantly repressed cell proliferation of PC in vitro. | 25412939 | Lnc2Cancer |
| EL0651 | LINC00261 | pancreatic cancer | qPCR, Western blot, knockdown etc. | PDAC tissue | down-regulated | expression | The upregulation of LINC00152 (MACE log2fc: 2.3, qPCR: 1.5) and downregulation of LINC00261 (MACE log2fc: 5.3, qPCR: 4.4) in PDAC tissues was confirmed by qPCR. | 25910082 | Lnc2Cancer |
| EL0746 | lincRNA-ZNF532 | pancreatic cancer | microarray, qPCR etc. | cell lines (SW1990, SWl990/GZ etc.) | up-regulated | expression | Six lncRNAs (RP11-58D2.1, lincRNA-ZNF532, AP000221.1, CTC-338M12.5, CR619813, DDX6P) were selected to validate the microarray consistency by using qPCR. The results demonstrated that RP11-58D2.1, lincRNA-ZNF532 and AP000221.1 were upregulated and that CTC-338M12.5, DDX6P and CR619813 were downregulated in the SW1990/GZ cells compared with SW1990 cells (Figure 6). | 25755691 | Lnc2Cancer |
| EL0747 | LINC-ROR | pancreatic cancer | qRT-PCR, RNA interference approaches, luciferase assays and RNA binding protein immunoprecipitation, immunohistochemistry assay | 61 paired cancerous and noncancerous tissue samples, pancreatic cancer stem cells (PCSCs) | up-regulated | expression | Knockdown of ROR by RNA interference in PCSCs inhibited proliferation, induced apoptosis and decreased migration. Moreover, ROR silencing resulted in significantly decreased tumourigenicity of PCSCs in nude mice than controls. | 26636540 | |
| EL0799 | lncRNA-ATB | pancreatic cancer | qPCR etc. | pancreatic cancer and paired adjacent normal pancreatic tissues, cell lines (HPDE6c-7) | down-regulated | expression | We found that lncRNA-ATB expression was decreased in pancreatic cancer tissues and pancreatic cancer cell lines. Low lncRNA-ATB expression levels were significantly correlated with lymph node metastases (yes vs. no, P = 0.009), neural invasion (positive vs. negative, P = 0.049), and clinical stage (early stage vs. advanced stage, P = 0.014). Moreover, patients with low lncRNA-ATB expression levels exhibited markedly worse overall survival prognoses (P < 0.001). Multivariate analysis indicated that decreased lncRNA-ATB expression was an independent predictor of poor prognosis in pancreatic cancer patients (P = 0.005). | 26482611 | Lnc2Cancer |
| EL0823 | LOC105372753 | pancreatic cancer | microarray, qPCR etc. | cell lines (SW1990, SWl990/GZ etc.) | up-regulated | expression | Six lncRNAs (RP11-58D2.1, lincRNA-ZNF532, AP000221.1, CTC-338M12.5, CR619813, DDX6P) were selected to validate the microarray consistency by using qPCR. The results demonstrated that RP11-58D2.1, lincRNA-ZNF532 and AP000221.1 were upregulated and that CTC-338M12.5, DDX6P and CR619813 were downregulated in the SW1990/GZ cells compared with SW1990 cells (Figure 6). | 25755691 | Lnc2Cancer |
| EL0825 | LOC105377769 | pancreatic cancer | microarray, qPCR etc. | cell lines (SW1990, SWl990/GZ etc.) | down-regulated | expression | Six lncRNAs (RP11-58D2.1, lincRNA-ZNF532, AP000221.1, CTC-338M12.5, CR619813, DDX6P) were selected to validate the microarray consistency by using qPCR. The results demonstrated that RP11-58D2.1, lincRNA-ZNF532 and AP000221.1 were upregulated and that CTC-338M12.5, DDX6P and CR619813 were downregulated in the SW1990/GZ cells compared with SW1990 cells (Figure 6). | 25755691 | Lnc2Cancer |
| EL0853 | MALAT1 | pancreatic cancer | Meta-analysis | non-small cell lung cancer and pancreatic cancer | up-regulated | expression | From subgroup analyses,we present evidence that lncRNA MALAT1 overexpression was an unfavorable prognostic factor for patients' overall survival in non-small cell lung cancer and pancreatic cancer, the pooled HRs (95% CI) were 1.86 (95% CI 1.27-2.73) and 1.78 (95% CI 1.30-2.44), respectively. In conclusion, lncRNA MALAT1 is a potential prognostic factor in human cancers. | 26131129 | |
| EL0853 | MALAT1 | pancreatic cancer | N/A | N/A | N/A | regulation | Sequesters SR splicing factors to regulate alternative splicing. | 22996375 | LncRNADisease |
| EL0853 | MALAT1 | pancreatic cancer | qPCR etc. | pancreatic cancer tissue | up-regulated | expression | Our results indicated that lncRNA MALAT1 was highly expressed in pancreatic cancer compared with adjacent non-cancerous tissues, and positively correlated with clinical stage, tumor size, lymph node metastasis, and distant metastasis in pancreatic cancer patients. Furthermore, we also found that lncRNA MALAT1 overexpression was an unfavorable prognostic factor in pancreatic cancer patients, regardless of clinical stage, tumor size, lymph node metastasis, and distant metastasis. Finally, increased lncRNA MALAT1 expression was an independent poor prognostic factor for pancreatic patients through multivariate analysis. | 25481511 | Lnc2Cancer |
| EL0853 | MALAT1 | pancreatic cancer | qPCR, Western blot etc. | cell lines (AsPC-1, CFPAC-1) | up-regulated | expression | In this study, our data showed that MALAT-1 could increase the proportion of pancreatic CSCs, maintain self-renewing capacity, decrease the chemosensitivity to anticancer drugs, and accelerate tumor angiogenesis in vitro. In addition, subcutaneous nude mouse xenografts revealed that MALAT-1 could promote tumorigenicity of pancreatic cancer cells in vivo. The underlying mechanisms may involve in increased expression of self-renewal related factors Sox2. | 25811929 | Lnc2Cancer |
| EL0853 | MALAT1 | pancreatic cancer | qPCR, Western blot, FCA etc. | pancreatic cancer tissue, cell lines (BxPC-3, CFPAC-1, CAPAN-1, SW1990 etc.) | up-regulated | expression | In the present study, our results showed that MALAT-1 expression levels were upregulated in pancreatic cancer tissues compared with adjacent noncancerous controls. Further function analysis revealed that downregulation of MALAT-1 could inhibit tumor cell proliferation and decrease cell migration and invasion in vitro. | 25269958 | Lnc2Cancer |
| EL0861 | MEG3 | pancreatic cancer | genome-wide LncRNA microarray analysis | pancreatic cancer cell lines | down-regulated | N/A | overexpression of MEG3 induced cells death and increased p53 expression | 26850851 | |
| EL1102 | PVT1 | pancreatic cancer | qPCR etc. | cell line (ASPC-1) | up-regulated | expression | PVT1 gene as a regulator of Gemcitabine sensitivity and showed that functional inactivation of the PVT1 gene led to enhanced Gemcitabine sensitivity in human pancreatic cancer ASPC-1 cells. | 21316338 | LncRNADisease Lnc2Cancer |
| EL1150 | ZBTB20-AS4 | pancreatic cancer | microarray, qPCR etc. | cell lines (SW1990, SWl990/GZ etc.) | up-regulated | expression | Six lncRNAs (RP11-58D2.1, lincRNA-ZNF532, AP000221.1, CTC-338M12.5, CR619813, DDX6P) were selected to validate the microarray consistency by using qPCR. The results demonstrated that RP11-58D2.1, lincRNA-ZNF532 and AP000221.1 were upregulated and that CTC-338M12.5, DDX6P and CR619813 were downregulated in the SW1990/GZ cells compared with SW1990 cells (Figure 6). | 25755691 | Lnc2Cancer |