Related LncRNAs |
ID |
lncRNA Name |
Disease |
Method |
Sample |
Expression pattern |
Dysfunction type |
Description |
PMID |
Source |
EL0556 |
H19 |
osteoarthritis |
cDNA array and quantitative RT-PCR |
OA and normal knee cartilage |
up-regulated |
interaction |
LncRNA H19 acts as a metabolic correlate in cartilage and cultured chondrocytes, while the miR-675 may indirectly influence COL2A1 levels. H19 may not only be an attractive marker for cell anabolism but also a potential target to stimulate cartilage recovery |
22527881 |
|
EL0861 |
MEG3 |
osteoarthritis |
RT-PCR |
articular cartilage samples from 20 Osteoarthritis (OA) patients |
down-regulated |
expression |
Maternally expressed gene 3 (MEG3) is a maternally expressed lncRNA and may function as a tumor suppressor by inhibiting angiogenesis. The results show that human MEG3 is significantly downregulated in OA patients compared to normal cartilage samples. MEG3 may be involved in OA development through the regulation of angiogenesis。 |
26090403 |
|
EL1443 |
VIM2P |
osteoarthritis |
qPCR,microarray,Western blot, and immunofluorescence analyses |
OA cartilage and normal cartilage |
up-regulated |
interaction |
LncRNA-CIR contributes to ECM degradation and plays a key role in the pathogenesis of OA. |
24757148 |
|
|