| Related LncRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
| EL0509 | FOXCUT | oral squamous cell carcinoma | qPCR, Western blot, knockdown etc. | OSCC tissue, cell lines (Tca8113, OSC-4, SCC1 etc.) | up-regulated | N/A | In this study, we report a new lncRNA FOXC1 upstream transcript (FOXCUT) that was remarkably overexpressed in 23 OSCC patients, as was the adjacent FOXC1 gene. The expressions of FOXC1 and FOXCUT were positively correlated. In conclusion, FOXC1 may be co-amplified with FOXCUT in OSCC, and both of them may be functionally involved in the tumor progression of OSCC. | 24889262 | Lnc2Cancer |
| EL0578 | HOTAIR | oral squamous cell carcinoma | N/A | N/A | N/A | expression | Subsequently, they confirmed that the expression levels of HOTAIR, NEAT-1 and UCA1 in metastasized samples was prominent higher than the non-metastatic samples.? | 24817925 | LncRNADisease |
| EL0578 | HOTAIR | oral squamous cell carcinoma | qPCR etc. | OSCC tissues | up-regulated | N/A | We found that most of the selected transcripts (4/6) were upregulated in tumors relative to matched adjacent nonmalignant tissue. One gene, MEG-3, was downregulated in cancer compared with its adjacent nonmalignant tissue. Expression of lncRNA (HOTAIR, NEAT-1 and UCA1) was significantly higher in the samples that subsequently metastasized compared with the non-metastatic samples. By contrast, MEG-3 was downregulated in the metastatic samples. These findings suggest that the detection of lncRNAs in saliva may be used as a noninvasive and rapid diagnostic tool for the diagnosis of oral cancer. | 23292713 | Lnc2Cancer |
| EL0578 | HOTAIR | oral squamous cell carcinoma | qPCR, Western blot, knockdown etc. | OSCC tissue, cell lines (TSCCA, Tca8223 etc.) | up-regulated | N/A | Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma. | 25901533 | LncRNADisease Lnc2Cancer |
| EL0853 | MALAT1 | oral squamous cell carcinoma | qPCR, Western blot, knockdown etc. | OSCC tissue, cell lines (Tscca, Tca8113P160, Tca8113, Hep-2) | up-regulated | interaction | We found that MALAT1 is overexpressed in OSCC tissues compared to normal oral mucosa by real-time PCR. MALAT1 served as a new prognostic factor in OSCC patients. When knockdown by small interfering RNA (siRNA) in OSCC cell lines TSCCA and Tca8113, MALAT1 was shown to be required for maintaining epithelial-mesenchymal transition (EMT) mediated cell migration and invasion. Western blot and immunofluorescence staining showed that MALAT1 knockdown significantly suppressed N-cadherin and Vimentin expression but induced E-cadherin expression in vitro. Meanwhile, both nucleus and cytoplasm levels of β-catenin and NF-B were attenuated, while elevated MALAT1 level triggered the expression of β-catenin and NF-B. More importantly, targeting MALAT1 inhibited TSCCA cell-induced xenograft tumor growth in vivo. | 26522444 | Lnc2Cancer |
| EL0861 | MEG3 | oral squamous cell carcinoma | qPCR etc. | OSCC tissues | down-regulated | N/A | We found that most of the selected transcripts (4/6) were upregulated in tumors relative to matched adjacent nonmalignant tissue. One gene, MEG-3, was downregulated in cancer compared with its adjacent nonmalignant tissue. Expression of lncRNA (HOTAIR, NEAT-1 and UCA1) was significantly higher in the samples that subsequently metastasized compared with the non-metastatic samples. By contrast, MEG-3 was downregulated in the metastatic samples. These findings suggest that the detection of lncRNAs in saliva may be used as a noninvasive and rapid diagnostic tool for the diagnosis of oral cancer. | 23292713 | Lnc2Cancer |
| EL0973 | NEAT1 | oral squamous cell carcinoma | N/A | N/A | N/A | expression | Subsequently, they confirmed that the expression levels of HOTAIR, NEAT-1 and UCA2 in metastasized samples was prominent higher than the non-metastatic samples.? | 24817925 | LncRNADisease |
| EL0973 | NEAT1 | oral squamous cell carcinoma | qPCR etc. | OSCC tissues | up-regulated | N/A | We found that most of the selected transcripts (4/6) were upregulated in tumors relative to matched adjacent nonmalignant tissue. One gene, MEG-3, was downregulated in cancer compared with its adjacent nonmalignant tissue. Expression of lncRNA (HOTAIR, NEAT-1 and UCA1) was significantly higher in the samples that subsequently metastasized compared with the non-metastatic samples. By contrast, MEG-3 was downregulated in the metastatic samples. These findings suggest that the detection of lncRNAs in saliva may be used as a noninvasive and rapid diagnostic tool for the diagnosis of oral cancer. | 23292713 | Lnc2Cancer |
| EL1431 | UCA1 | oral squamous cell carcinoma | N/A | N/A | N/A | expression | Subsequently, they confirmed that the expression levels of HOTAIR, NEAT-1 and UCA3 in metastasized samples was prominent higher than the non-metastatic samples.? | 24817925 | LncRNADisease |
| EL1431 | UCA1 | oral squamous cell carcinoma | qPCR etc. | OSCC tissues | up-regulated | N/A | We found that most of the selected transcripts (4/6) were upregulated in tumors relative to matched adjacent nonmalignant tissue. One gene, MEG-3, was downregulated in cancer compared with its adjacent nonmalignant tissue. Expression of lncRNA (HOTAIR, NEAT-1 and UCA1) was significantly higher in the samples that subsequently metastasized compared with the non-metastatic samples. By contrast, MEG-3 was downregulated in the metastatic samples. These findings suggest that the detection of lncRNAs in saliva may be used as a noninvasive and rapid diagnostic tool for the diagnosis of oral cancer. | 23292713 | Lnc2Cancer |