Related LncRNAs
ID	lncRNA Name	Disease	Method	Sample	Expression pattern	Dysfunction type	Description	PMID	Source
EL0578	HOTAIR	non-functioning pituitary adenoma	microarray, qPCR etc.	NFPA tissue	up-regulated	expression	Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior.	24469926	LncRNADisease Lnc2Cancer
EL0861	MEG3	non-functioning pituitary adenoma	inducible and constitutively active expression systems	PDFS cells derived from a human NFA (non-functioning pituitary adenomas)	up-regulated	expression	MEG3 expression significantly suppressed xenograft tumor growth in vivo in nude mice. When induced in culture, MEG3 caused cell cycle arrest at the G1 phase.	26284494
EL0861	MEG3	non-functioning pituitary adenoma	microarray, qPCR etc.	NFPA tissue	down-regulated	N/A	qPCR analyses showed that MEG3 expression was lost in 32 of 52 NFPAs (61.5 %). In addition, MEG3 lncRNA levels were significantly decreased in invasive NFPAs and non-invasive NFPAs compared to normal anterior pituitaries. Furthermore, MEG3 expression was significantly decreased in invasive NFPAs compared to non-invasive NFPAs.	24469926	LncRNADisease Lnc2Cancer
EL0861	MEG3	non-functioning pituitary adenoma	qPCR etc.	pituitary tumor tissue	down-regulated	epigenetics	Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors.	15644399	LncRNADisease Lnc2Cancer
EL0861	MEG3	non-functioning pituitary adenoma	qPCR etc.	pituitary tumor tissue	down-regulated	expression	Maternally Expressed Gene 3 (MEG3), which is specifically associated with clinically non-functioning pituitary adenomas of a gonadotroph lineage.	20211686	LncRNADisease Lnc2Cancer
EL0861	MEG3	non-functioning pituitary adenoma	qPCR etc.	pituitary adenoma tissue	down-regulated	expression	The DLK1-MEG3 locus is silenced in NFAs (nonfunctioning adenomas). The DLK1-MEG3 locus plays a tumor suppressor role in human NFAs.	21871428	LncRNADisease Lnc2Cancer
EL0861	MEG3	non-functioning pituitary adenoma	qPCR, ISH etc.	pituitary tumor tissue	down-regulated	epigenetics	Selective loss of MEG3 expression and intergenic differentially methylated region hypermethylation in the MEG3/DLK1 locus in human clinically nonfunctioning pituitary adenomas.	18628527	LncRNADisease Lnc2Cancer
EL0862	Meg3	non-functioning pituitary adenoma	Quantitative RT-PCR immunohistological	Meg3 knockout mice	up-regulated	expression	Meg3 may play an important role in control of vascularization in the brain and may function as a tumor suppressor in part by inhibiting angiogenesis	20392836