| Related LncRNAs | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ID | lncRNA Name | Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source |
| EL0344 | DLEU2 | lymphoma | qPCR, Western blot, Northern blot, Luciferase reporter assay etc. | cell lines (HEK293, U2OS etc.) | down-regulated | expression | The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. | 19591824 | LncRNADisease Lnc2Cancer |
| EL0526 | GAS5 | lymphoma | knockdown etc. | cell lines (Jeko-124 and Z-138) | down-regulated | N/A | Downregulation of GAS5 substantially reduced the effects of each rapalogue on cell viability, DNA synthesis, and colony-forming ability.Stimulation of expression of candidate tumor suppressor GAS5 is responsible for much of the cytotoxic and cytostatic effects of rapalogues in MCL, suggesting that improved targeting of this pathway may allow improvements in the therapy of this intractable lymphoma. | 24703244 | Lnc2Cancer |
| EL0526 | GAS5 | lymphoma | N/A | N/A | N/A | mutation | The GAS5 (growth arrest-specific transcript 5) gene fuses to BCL6 as a result of t(1;3)(q25;q27) in a patient with B-cell lymphoma. | 18406879 | LncRNADisease |
| EL0526 | GAS5 | lymphoma | N/A | N/A | N/A | mutation | Chromosomal translocations affecting the 1q25 locus containing the Gas5 gene have been detected in melanoma, B-cell lymphoma, and prostate and breast cancer. | 18836484 | LncRNADisease Lnc2Cancer |
| EL1102 | PVT1 | lymphoma | N/A | N/A | N/A | N/A | Burkitt lymphoma association | 2470097 | LncRNADisease |
| EL1102 | PVT1 | lymphoma | N/A | N/A | N/A | N/A | Burkitt lymphoma association | 3024964 | LncRNADisease |
| EL1231 | SNHG5 | lymphoma | N/A | N/A | N/A | locus | snhg5 is located at the breakpoint of chromosomal translocation t(3;6)(q27;q15) involved in human B-cell lymphoma. | 10792466 | LncRNADisease |